Investigating Cu(II) Complexes for MRI: A Comprehensive Approach Using EPR, Relaxometry, and Computational Modeling

The development of Gd-free MRI contrast agents requires a detailed understanding of the structural and electronic factors governing paramagnetic relaxation in first-row transition-metal complexes. In this work, we integrate EPR spectroscopy, Q-band ENDOR, variable-temperature 17O NMR, field-dependent 1H relaxometry, and DFT calculations to dissect the structure–relaxivity relationships of two prototypical Cu(II) systems: [Cu(TACN)]2+ and [Cu(TREN)]2+. These complexes differ markedly in geomet...

Nutritional knowledge in patients with severe obesity during a residential rehabilitation: the relationships with socio-demographic variables

Background: This study was aimed at evaluating the enhancement of nutritional knowledge in severely obese patients participating in a residential rehabilitation program, by means of the Moynihan Questionnaire (M.Q.). It further explored the association between learning outcomes and socio-demographic variables. Method: A cohort of 2888 obese patients (mean Body Mass Index, BMI: 44 ± 7 kg/m^2, mean age 59 yrs.), admitted to Auxologico Piancavallo for metabolic rehabilitation was investigated. P...

Informare gli studenti sulla borsa di studio: quale effetto sul passaggio scuola-università?

L’art. 1362 c.c. e l’interpretazione dei contratti collettivi di diritto comune

Il saggio analizza la questione dell’applicabilità dell’art. 1362 c.c. al processo di interpretazione dei contratti collettivi, tradizionalmente negata dalla dottrina in favore dei criteri di interpretazione oggettiva. Dopo aver verificato la validità e vitalità delle ragioni in base alle quali è stato proposto l’accantonamento dell’art. 1362 c.c., il lavoro mira a indagare se non sussistano ragioni per riabilitare la “comune intenzione” quale criterio guida del procedimento ermeneutico, anch...