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Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification

Pleural mesothelioma (PM) is a lethal cancer primarily caused by asbestos exposure. Not all exposed individuals develop PM, suggesting the involvement of additional factors. This underscores the need for robust predictive models integrating biomarkers from multi-omic domains to improve risk stratification and early detection. We developed and evaluated polygenic risk scores (PRS) and methylation risk scores (MRS) using a retrospective case–control study (749 participants: 387 PM cases, 362 co...

Divisione del lavoro e strategie negoziali tra professionisti: uno sguardo sociologico sull’ageismo nei contesti ospedalieri.

Facendo riferimento alla teoria dell’ordine negoziato di Strauss (1985), l’articolo analizza le pratiche quotidiane di medici, infermieri e assistenti sociali in quattro servizi ambulatoriali italiani rivolti a pazienti anziani con declino cognitivo o insufficienza cardiaca. Attraverso un approccio qualitativo basato su 19 interviste, lo studio esplora come i professionisti interpretano e affrontano i vincoli organizzativi che incidono sulle negoziazioni tra gli attori e sulle interazioni ter...

Processi di invecchiamento, ageismo e cura nei contesti ospedalieri: attori, pratiche e prospettive teoriche

The ageing of the population, a complex phenomenon that increasingly challenges contempo-rary societies, calls for multidimensional analysis and critical reflection on its social construction. This article, which introduces the Special Issue, explores key sociological themes, que-stioning the persistent dichotomies between autonomy and dependancy and between agency and passivity, that often frame the discourse on ageing. It begins by reflecting on the socio-cultural dimensions of ageing, cont...

Early lung ultrasound score changes predict the failure of non-invasive respiratory supports in acute hypoxemic patients: a multicenter prospective observational study

Background: To determine whether lung ultrasound (LUS) may early predict the failure of non-invasive respiratory support (high-flow nasal cannula-HFNC, continuous positive airway pressure-CPAP, non-invasive ventilation-NIV) in hypoxemic patients. Methods: In this prospective multicenter international observational study, we enrolled patients undergoing non-invasive treatments for hypoxemia (PaO2/FiO2 < 300 mmHg). LUS, PaO2/FiO2 and ROX index were assessed before (baseline) and 2 h after treat...

Mitochondrial Dysfunction: The Cellular Bridge from Emo-tional Stress to Disease Onset. A narrative review

Severe emotional stress constitutes a significant public-health concern associated with negative health outcomes. Although the clinical effects are well acknowledged, the specific biological mechanisms that translate emotional suffering into systemic disease remain incompletely understood. Psychological stress activates the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, which directly target mitochondria and alter their bioenergetic and redox capacity. For this reason, th...

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