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Posterior versus anterior circulation infarct location and outcomes after breakthrough ischemic stroke in orally anticoagulated patients for atrial fibrillation: An ASPERA-R inverse probability–weighted analysis

Introduction and aims: Breakthrough ischemic stroke may occur despite ongoing oral anticoagulation (OAC) in patients with atrial fibrillation (AF). Whether infarct location influences prognosis remains unclear. We aimed to compare clinical characteristics and outcomes of posterior versus anterior circulation infarct (PCI vs ACI). Methods: Multicentre retrospective analysis from the ASPERA cohort, including patients with AF and ischemic stroke despite continuous OAC (Feb. 2020 to Feb. 2025). P...

Don't exhaust, don't waste: Resource-aware soundness for big-step semantics

We extend the semantics and type system of a lambda calculus equipped with common constructs to be "resource-aware". That is, the semantics keeps track of the usage of resources, and is stuck, besides in case of type errors, if either a needed resource is exhausted, or a provided resource would be wasted. In such way, the type system guarantees, besides standard soundness, that for well-typed programs there is a computation where no resource gets either exhausted or wasted. The extension is p...

Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta‐Cell Function in Migrant‐Background Populations

Aims: To investigate associations between migrant status, socioeconomic factors (SES), and residual beta-cell function and glycemic outcomes in paediatric type 1 diabetes. Methods: Retrospective study of 208 children (median [IQR] age 11 [8-14] years; 119 Italian, 89 from migrant-background families) with glucometric (HbA1c, TIR, TITR, TAR, CV), SES (maternal/paternal education, language, income), and metabolic data. Univariable and exploratory multivariable regression analyses identified fac...

NR0B1 Gene Variants as Rare Forms of Primary Adrenal Insufficiency in Children: Case Report and Narrative Review

Primary adrenal insufficiency (PAI) is a severe and potentially life-threatening condition characterised by the inability of the adrenal cortex to produce enough glucocorticoids and/or mineralocorticoids. The clinical signs of PAI are primarily due to deficient steroid hormone synthesis and include weight loss, orthostatic hypotension secondary to dehydration, hyponatremia, hyperkalaemia, and hypoglycaemia. In the paediatric population, PAI is most commonly associated with inherited monogenic...

Expression of human endogenous retroviruses (HERVs) in the blood of adolescents with and without obesity

Background/Objectives: Human endogenous retroviruses (HERVs) are genomic elements derived from ancient retroviral infections and are increasingly recognized for their roles in gene regulation and immune modulation. Obesity is characterized by chronic low-grade inflammation and metabolic dysregulation, which may influence HERV expression. Subjects/Methods: In this study, we evaluated the transcriptional levels of HERV-H-pol, HERV-K-pol, and HERV-W-pol in peripheral blood from adolescents with ...

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