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Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mechanisms and Health Implications

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are persistent environmental pollutants, raising concerns due to their widespread presence and disruptive biological effects. These compounds are highly stable, allowing them to bioaccumulate in the environment and living organisms, potentially impacting critical physiological functions such as hormonal balance, immune response, and increasing cancer risk. Despite regulatory restrictions, their pervasive nature necessitates fu...

Giovan Battista Fidanza: Andrea Sacchi and Cardinal Del Monte: The Rediscovered Frescoes in the Palazzo di Ripetta in Rome, Londres, Ad Ilissvm, 2022, xii + 132 pp.

“No safe level” ed etichettatura precauzionale degli alcolici: una questione da affrontare

La recente normativa irlandese sulle avvertenze precauzionali nell’etichettatura degli alcolici ha dato la stura a numerose polemiche in merito al rischio che una eccessiva demonizzazione del consumo di alcolici possa distruggere il mercato di prodotti che da millenni hanno contribuito alla costruzione dell’identità culturale, sociale ed economica dei popoli europei. L’articolo muove da alcuni dati scientifici recenti, che hanno segnalato la difficoltà (se, non, l’impossibilità) di identifica...

Croplands proximity is associated with amyotrophic lateral sclerosis incidence and age at onset

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from an intricate interplay between genetics and environmental factors. Many studies have explored living in rural areas as a possible risk factor for ALS, without focusing simultaneously on incidence, age at onset and phenotypic features. Objective: To evaluate the effect of croplands residential proximity on ALS incidence and phenotype, focusing on age of onset, site of onset and progression rate. Metho...

Systemic therapy with lenvatinib in advanced hepatocellular carcinoma: what to do in the case of a complete radiologic response?

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