Serum Free Medium

In-vitro cell-based assays are widely used to characterize a molecule's bioactivity or quantify the potency of clinical and marketed drugs, as requested by regulatory authorities. Fetal Bovine Serum (FBS) is the gold standard of cell supplements but at the same time, it is one of the most critical reagents for cell culture. Firstly, FBS collection causes suffering to animals. Secondly, FBS is one of the higher sources of cell culture contamination. Finally, FBS composition is not completely c...

inibitori del carrier del citrato nel trattamento dell'infiammazione

La presente invenzione riguarda l’acido 4-cloro-3-{[(3-nitrofenil)amino]sulfonil} benzoico (CNFASB), uno specifico inibitore del carrier mitocondriale del citrato (CIC). Il carrier del citrato (CIC), catalizza lo scambio elettroneutro tra citrato (H-citrato2-) e la forma non protonata del malato (malato2-). Il citrato esportato dai mitocondri verso il citosol, mediante il CIC, è scisso dall’ATP-citrato liasi (CL) in ossalacetato e acetilCoA che porterà alla biosintesi di steroli e acidi grass...

Biosensore elettrochimico e metodo per la rilevazione di contaminanti ambientali

Organismo geneticamente modificado com proteínas derivadas de espécies pertencentes ao gênero crassostrea, processo de biorremediação de um ambiente compreendendo metais pesados, e processo de biomineração de um ambiente compreendendo metais pesados

genetically modified organism with proteins derived from species belonging to the genus crassostrea, process of bioremediation of an environment comprising heavy metals, and process of biomineration of an environment comprising heavy metals the present invention describes genetically modified organisms capable of expressing a synthetic gene with multiple copies of metal binding domains of crassostrea rhizophorae metallothionein. this new organism is capable of removing heavy metals from envir...