IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 3.187
NA - Nord America 2.486
AS - Asia 1.775
SA - Sud America 217
AF - Africa 71
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
Totale 7.743
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Nazione #
US - Stati Uniti d'America 2.406
RU - Federazione Russa 698
IT - Italia 647
SG - Singapore 527
IE - Irlanda 475
CN - Cina 437
DE - Germania 394
SE - Svezia 286
VN - Vietnam 253
HK - Hong Kong 218
UA - Ucraina 171
BR - Brasile 166
FI - Finlandia 130
FR - Francia 124
IN - India 100
GB - Regno Unito 85
TR - Turchia 50
CA - Canada 45
BD - Bangladesh 28
IR - Iran 28
NL - Olanda 26
BJ - Benin 25
JP - Giappone 25
KR - Corea 25
MX - Messico 23
EE - Estonia 22
CZ - Repubblica Ceca 21
ES - Italia 20
BE - Belgio 19
AR - Argentina 16
IQ - Iraq 16
PL - Polonia 16
ID - Indonesia 14
EC - Ecuador 13
LT - Lituania 13
AT - Austria 12
ZA - Sudafrica 10
MA - Marocco 9
PK - Pakistan 8
SA - Arabia Saudita 8
VE - Venezuela 8
UZ - Uzbekistan 6
AE - Emirati Arabi Uniti 5
EG - Egitto 5
KE - Kenya 5
TW - Taiwan 5
DK - Danimarca 4
EU - Europa 4
JO - Giordania 4
MY - Malesia 4
PE - Perù 4
PH - Filippine 4
PY - Paraguay 4
BG - Bulgaria 3
CH - Svizzera 3
CL - Cile 3
DZ - Algeria 3
ET - Etiopia 3
GR - Grecia 3
MD - Moldavia 3
RO - Romania 3
TH - Thailandia 3
AU - Australia 2
BY - Bielorussia 2
GA - Gabon 2
GT - Guatemala 2
JM - Giamaica 2
NO - Norvegia 2
NP - Nepal 2
SV - El Salvador 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AO - Angola 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CG - Congo 1
CI - Costa d'Avorio 1
CO - Colombia 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
HN - Honduras 1
HU - Ungheria 1
IL - Israele 1
KW - Kuwait 1
LB - Libano 1
LV - Lettonia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PA - Panama 1
PT - Portogallo 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
SY - Repubblica araba siriana 1
UY - Uruguay 1
Totale 7.743
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Città #
Dublin 475
Jacksonville 292
San Jose 261
Singapore 219
Hong Kong 215
Ashburn 166
Dearborn 161
Beijing 138
Piemonte 122
Chandler 108
Wilmington 83
Novara 80
Moscow 78
Ho Chi Minh City 77
Ann Arbor 75
Munich 74
Los Angeles 72
Hanoi 67
Council Bluffs 55
Lauterbourg 55
Lawrence 53
Princeton 53
Helsinki 48
New York 44
Turin 44
Milan 42
Bremen 36
Buffalo 31
San Mateo 31
Andover 28
Frankfurt am Main 28
Santa Clara 26
São Paulo 26
Cotonou 25
Ankara 24
Dallas 24
Orem 23
Chennai 21
Seoul 20
Turku 20
Brussels 19
Tokyo 19
Falkenstein 18
Montreal 18
Stockholm 16
Toronto 16
Hefei 15
Monmouth Junction 15
Rome 15
Brno 14
Redondo Beach 14
Vercelli 14
Amsterdam 13
Mexico City 13
Warsaw 13
Boardman 12
Chicago 12
Denver 12
Nanjing 12
Seattle 12
Da Nang 11
Nuremberg 11
San Francisco 11
Tianjin 11
Atlanta 10
Boston 10
Guangzhou 10
Jakarta 10
Mülheim 10
Roubaix 10
Zola Predosa 10
Johannesburg 9
Kocaeli 9
Norwalk 9
Phoenix 9
Poplar 9
Torino 9
Ardabil 8
Borgomanero 8
Chengdu 8
Bari 7
Biên Hòa 7
Florence 7
Haiphong 7
Hangzhou 7
Houston 7
Leawood 7
London 7
Manchester 7
Prague 7
Baghdad 6
Bologna 6
Brooklyn 6
Hillsboro 6
Jinan 6
Sacramento 6
Tashkent 6
Verona 6
Zanjan 6
Barnet 5
Totale 4.133
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Nome #
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 178
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 168
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 166
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 165
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 160
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 160
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 155
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 153
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 147
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 143
La spettrometria di massa negli studi di stabilità dei farmaci 143
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 142
CBD and CBG permeation study through an artificial skin-biomimetic membrane 140
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 140
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 138
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 137
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 135
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 134
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 130
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 129
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 127
Medicinal Chemistry of Isocyanides 127
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 126
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 124
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 123
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 122
An aryne-based three-component access to α-aroylamino amides 121
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 120
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 119
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 119
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 119
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 117
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 113
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 112
Spray-drying of oil-in-gel emulsions containing cannabigerol 108
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 108
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 107
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 107
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 102
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 101
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 100
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 98
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 98
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 96
Forced degradation study of thiocolchicoside: Characterization of its degradation products 96
Soft drugs for dermatological applications: recent trends 96
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 94
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 93
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 93
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 92
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 92
Injectable medicated graft substitute active on bone tissue regeneration 92
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 91
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 89
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 88
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 87
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 85
Topical emulgels and powders containing Cannabis sativa L. extracts 84
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 83
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 83
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 82
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 81
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 77
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 77
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 77
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 74
In-water synthesis of isocyanides under micellar conditions 67
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 67
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 65
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 51
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation 43
Bacillus subtilis AC7 Fermentation on Rice Husk Substrate: A Sustainable Approach for Lipopeptide Biosurfactant Production 2
Totale 7.878
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Categoria #
all - tutte 35.456
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.456
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202117 0 0 0 0 0 0 0 0 0 0 0 17
2021/2022484 30 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/20251.074 38 31 66 34 58 139 128 94 185 72 30 199
2025/20263.266 166 103 192 442 395 219 401 556 200 320 205 67
Totale 7.878