IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 1.870
NA - Nord America 1.378
AS - Asia 443
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 4
AF - Africa 2
Totale 3.702
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Nazione #
US - Stati Uniti d'America 1.365
IE - Irlanda 472
IT - Italia 472
SE - Svezia 271
DE - Germania 270
UA - Ucraina 158
SG - Singapore 131
CN - Cina 115
FI - Finlandia 94
IN - India 63
HK - Hong Kong 56
GB - Regno Unito 40
TR - Turchia 37
IR - Iran 28
CZ - Repubblica Ceca 18
BE - Belgio 16
RU - Federazione Russa 14
CA - Canada 13
FR - Francia 11
NL - Olanda 8
AT - Austria 5
DK - Danimarca 4
ES - Italia 4
EU - Europa 4
JP - Giappone 4
LT - Lituania 4
GR - Grecia 3
PE - Perù 3
CH - Svizzera 2
EG - Egitto 2
KR - Corea 2
NO - Norvegia 2
PK - Pakistan 2
VN - Vietnam 2
BG - Bulgaria 1
BO - Bolivia 1
CL - Cile 1
IQ - Iraq 1
JO - Giordania 1
LV - Lettonia 1
PH - Filippine 1
Totale 3.702
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Città #
Dublin 472
Jacksonville 292
Dearborn 161
Piemonte 122
Chandler 108
Singapore 103
Wilmington 83
Ann Arbor 75
Hong Kong 55
Lawrence 53
Princeton 53
Beijing 44
Bremen 36
Helsinki 32
San Mateo 31
Milan 29
Turin 29
Andover 28
Novara 26
Ashburn 20
Ankara 19
Munich 19
Brussels 16
Monmouth Junction 15
Brno 14
Hefei 14
Vercelli 13
Nanjing 12
Santa Clara 12
Boardman 11
Mülheim 10
Toronto 10
Zola Predosa 10
Kocaeli 9
Norwalk 9
Torino 9
Ardabil 8
Dallas 8
Bari 7
Leawood 7
Jinan 6
Rome 6
Sacramento 6
Seattle 6
Zanjan 6
Busto Arsizio 5
Houston 5
Straubing 5
Amsterdam 4
Biella 4
Cassano Magnago 4
Chengdu 4
Fairfield 4
Formigine 4
Frankfurt am Main 4
Kunming 4
Nanchang 4
Prague 4
Shenyang 4
Villach 4
Woodbridge 4
Zhengzhou 4
Athens 3
Berlin 3
Como 3
Grignasco 3
Ipswich 3
Kecioeren 3
Lima 3
Lyngby 3
Madrid 3
Modena 3
Montesarchio 3
Nürnberg 3
Oggiono 3
Palermo 3
Strasbourg 3
Verona 3
Bangalore 2
Bellinzago Novarese 2
Bologna 2
Borgomanero 2
Borgomasino 2
Cairo 2
Cerano 2
Chivasso 2
Dong Ket 2
Düsseldorf 2
Falkenstein 2
Fuzhou 2
Grafing 2
Islamabad 2
La Canada Flintridge 2
Lomazzo 2
London 2
Los Angeles 2
Meppel 2
Padova 2
Pavia 2
Phoenix 2
Totale 2.277
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Nome #
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 112
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 101
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 100
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 98
La spettrometria di massa negli studi di stabilità dei farmaci 90
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 90
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 85
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 85
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 84
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 84
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 82
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 82
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 78
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 76
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 76
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 74
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 74
An aryne-based three-component access to α-aroylamino amides 70
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 68
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 67
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 65
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 64
Forced degradation study of thiocolchicoside: Characterization of its degradation products 63
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 63
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 63
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 62
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 59
CBD and CBG permeation study through an artificial skin-biomimetic membrane 58
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 57
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 57
Spray-drying of oil-in-gel emulsions containing cannabigerol 56
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 56
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 55
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 53
Injectable medicated graft substitute active on bone tissue regeneration 53
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 53
Soft drugs for dermatological applications: recent trends 52
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 51
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 51
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 51
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 51
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 49
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 48
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 48
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 46
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 46
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 45
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 45
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 44
Medicinal Chemistry of Isocyanides 44
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 42
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 42
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 41
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 40
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 40
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 39
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 38
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 37
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 34
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 34
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 28
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 25
Topical emulgels and powders containing Cannabis sativa L. extracts 24
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 19
In-water synthesis of isocyanides under micellar conditions 13
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 12
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 12
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 9
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 8
Totale 3.821
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Categoria #
all - tutte 20.870
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 20.870
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020488 0 0 0 0 0 115 132 28 63 67 76 7
2020/2021456 58 3 53 9 48 51 56 6 67 34 54 17
2021/2022484 30 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/2025283 38 31 66 34 58 56 0 0 0 0 0 0
Totale 3.821