IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 2.435
NA - Nord America 1.974
AS - Asia 1.212
SA - Sud America 182
AF - Africa 49
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
Totale 5.859
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Nazione #
US - Stati Uniti d'America 1.917
IT - Italia 606
IE - Irlanda 473
SG - Singapore 387
DE - Germania 377
SE - Svezia 283
CN - Cina 277
HK - Hong Kong 209
UA - Ucraina 168
BR - Brasile 142
FI - Finlandia 129
RU - Federazione Russa 129
IN - India 88
VN - Vietnam 81
GB - Regno Unito 68
FR - Francia 51
TR - Turchia 44
CA - Canada 33
IR - Iran 28
BJ - Benin 25
EE - Estonia 24
KR - Corea 22
NL - Olanda 22
JP - Giappone 20
BE - Belgio 18
CZ - Repubblica Ceca 18
ES - Italia 16
MX - Messico 16
AR - Argentina 14
ID - Indonesia 14
LT - Lituania 13
PL - Polonia 13
AT - Austria 11
BD - Bangladesh 10
EC - Ecuador 9
ZA - Sudafrica 8
IQ - Iraq 7
MA - Marocco 7
VE - Venezuela 6
UZ - Uzbekistan 5
DK - Danimarca 4
EG - Egitto 4
EU - Europa 4
PE - Perù 4
PK - Pakistan 4
SA - Arabia Saudita 4
AE - Emirati Arabi Uniti 3
BG - Bulgaria 3
GR - Grecia 3
JO - Giordania 3
PY - Paraguay 3
AU - Australia 2
CH - Svizzera 2
CL - Cile 2
NO - Norvegia 2
TT - Trinidad e Tobago 2
TW - Taiwan 2
BO - Bolivia 1
CD - Congo 1
CG - Congo 1
CI - Costa d'Avorio 1
CO - Colombia 1
DM - Dominica 1
DZ - Algeria 1
GT - Guatemala 1
HN - Honduras 1
IL - Israele 1
JM - Giamaica 1
KW - Kuwait 1
LV - Lettonia 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PA - Panama 1
PH - Filippine 1
SK - Slovacchia (Repubblica Slovacca) 1
SV - El Salvador 1
TN - Tunisia 1
Totale 5.859
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Città #
Dublin 473
Jacksonville 292
Hong Kong 208
Singapore 169
Dearborn 161
Beijing 137
Ashburn 131
Piemonte 122
Chandler 108
Novara 86
Wilmington 83
Munich 77
Ann Arbor 75
Los Angeles 61
Lawrence 53
Princeton 53
Moscow 52
Helsinki 46
Milan 41
Turin 41
Bremen 36
Buffalo 32
New York 32
San Mateo 31
Andover 28
Cotonou 25
Ankara 24
Ho Chi Minh City 24
Hanoi 22
São Paulo 22
Turku 21
Seoul 19
Brussels 18
Dallas 18
Frankfurt am Main 17
Chennai 16
Santa Clara 16
Tokyo 16
Monmouth Junction 15
Vercelli 15
Brno 14
Falkenstein 14
Hefei 14
Redondo Beach 14
Stockholm 14
Rome 13
Toronto 13
Nanjing 12
Amsterdam 11
Boardman 11
Montreal 11
Seattle 11
Jakarta 10
Mülheim 10
Nuremberg 10
Roubaix 10
Warsaw 10
Zola Predosa 10
Boston 9
Kocaeli 9
Norwalk 9
Orem 9
Poplar 9
Torino 9
Ardabil 8
Atlanta 8
Borgomanero 8
Bari 7
Chicago 7
Denver 7
Houston 7
Johannesburg 7
Leawood 7
Mexico City 7
Phoenix 7
San Francisco 7
Tianjin 7
Brooklyn 6
Jinan 6
Sacramento 6
Verona 6
Zanjan 6
Biên Hòa 5
Busto Arsizio 5
Porto Alegre 5
Straubing 5
Tashkent 5
Bexley 4
Biella 4
Bologna 4
Brasília 4
Cassano Magnago 4
Chengdu 4
Fairfield 4
Formigine 4
Guarulhos 4
Kunming 4
Lima 4
London 4
Mumbai 4
Totale 3.383
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Nome #
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 143
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 139
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 129
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 127
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 126
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 124
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 124
La spettrometria di massa negli studi di stabilità dei farmaci 121
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 115
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 113
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 113
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 112
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 111
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 111
CBD and CBG permeation study through an artificial skin-biomimetic membrane 108
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 100
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 100
null 100
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 99
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 98
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 96
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 96
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 95
An aryne-based three-component access to α-aroylamino amides 94
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 94
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 94
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 93
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 92
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 89
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 88
Medicinal Chemistry of Isocyanides 87
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 86
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 85
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 84
Spray-drying of oil-in-gel emulsions containing cannabigerol 83
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 81
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 81
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 80
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 78
Forced degradation study of thiocolchicoside: Characterization of its degradation products 77
Soft drugs for dermatological applications: recent trends 76
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 74
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 74
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 73
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 72
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 72
Injectable medicated graft substitute active on bone tissue regeneration 72
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 71
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 70
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 70
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 69
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 68
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 68
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 67
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 67
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 65
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 64
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 64
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 64
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 64
Topical emulgels and powders containing Cannabis sativa L. extracts 62
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 60
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 59
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 57
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 57
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 51
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 45
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 45
In-water synthesis of isocyanides under micellar conditions 45
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 44
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation 16
Totale 5.991
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Categoria #
all - tutte 30.835
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.835
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021285 0 0 0 0 0 51 56 6 67 34 54 17
2021/2022484 30 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/20251.092 38 31 66 34 58 139 128 102 189 74 30 203
2025/20261.361 172 106 198 446 403 36 0 0 0 0 0 0
Totale 5.991