IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 2.441
NA - Nord America 1.999
AS - Asia 1.246
SA - Sud America 193
AF - Africa 56
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
Totale 5.942
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Nazione #
US - Stati Uniti d'America 1.937
IT - Italia 606
IE - Irlanda 473
SG - Singapore 390
DE - Germania 377
SE - Svezia 284
CN - Cina 281
HK - Hong Kong 210
UA - Ucraina 168
BR - Brasile 151
RU - Federazione Russa 130
FI - Finlandia 129
VN - Vietnam 96
IN - India 88
GB - Regno Unito 68
FR - Francia 51
TR - Turchia 44
CA - Canada 37
IR - Iran 28
BJ - Benin 25
EE - Estonia 24
NL - Olanda 23
KR - Corea 22
JP - Giappone 20
BE - Belgio 18
CZ - Repubblica Ceca 18
ES - Italia 17
MX - Messico 17
AR - Argentina 14
ID - Indonesia 14
PL - Polonia 14
LT - Lituania 13
AT - Austria 11
IQ - Iraq 11
BD - Bangladesh 10
EC - Ecuador 10
ZA - Sudafrica 9
MA - Marocco 8
PK - Pakistan 6
UZ - Uzbekistan 6
VE - Venezuela 6
SA - Arabia Saudita 5
DK - Danimarca 4
EG - Egitto 4
EU - Europa 4
JO - Giordania 4
PE - Perù 4
AE - Emirati Arabi Uniti 3
BG - Bulgaria 3
CL - Cile 3
GR - Grecia 3
PY - Paraguay 3
AU - Australia 2
CH - Svizzera 2
GA - Gabon 2
NO - Norvegia 2
TT - Trinidad e Tobago 2
TW - Taiwan 2
BO - Bolivia 1
BW - Botswana 1
BY - Bielorussia 1
CD - Congo 1
CG - Congo 1
CI - Costa d'Avorio 1
CO - Colombia 1
DM - Dominica 1
DZ - Algeria 1
GT - Guatemala 1
HN - Honduras 1
IL - Israele 1
JM - Giamaica 1
KW - Kuwait 1
LV - Lettonia 1
MY - Malesia 1
NG - Nigeria 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PA - Panama 1
PH - Filippine 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
SV - El Salvador 1
SY - Repubblica araba siriana 1
TN - Tunisia 1
Totale 5.942
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Città #
Dublin 473
Jacksonville 292
Hong Kong 209
Singapore 172
Dearborn 161
Beijing 137
Ashburn 135
Piemonte 122
Chandler 108
Novara 86
Wilmington 83
Munich 77
Ann Arbor 75
Los Angeles 63
Lawrence 53
Princeton 53
Moscow 52
Helsinki 46
Milan 41
Turin 41
Bremen 36
New York 33
Buffalo 32
Ho Chi Minh City 32
San Mateo 31
Andover 28
Hanoi 27
Cotonou 25
Ankara 24
São Paulo 23
Turku 21
Seoul 19
Brussels 18
Dallas 18
Frankfurt am Main 17
Santa Clara 17
Chennai 16
Tokyo 16
Monmouth Junction 15
Stockholm 15
Vercelli 15
Brno 14
Falkenstein 14
Hefei 14
Redondo Beach 14
Toronto 14
Montreal 13
Orem 13
Rome 13
Amsterdam 12
Nanjing 12
Boardman 11
Seattle 11
Warsaw 11
Denver 10
Jakarta 10
Mülheim 10
Nuremberg 10
Roubaix 10
Zola Predosa 10
Atlanta 9
Boston 9
Kocaeli 9
Norwalk 9
Poplar 9
Torino 9
Ardabil 8
Borgomanero 8
Chicago 8
Johannesburg 8
Mexico City 8
Tianjin 8
Bari 7
Houston 7
Leawood 7
Phoenix 7
San Francisco 7
Biên Hòa 6
Brooklyn 6
Jinan 6
Sacramento 6
Tashkent 6
Verona 6
Zanjan 6
Busto Arsizio 5
Porto Alegre 5
Rio de Janeiro 5
Straubing 5
Amman 4
Baghdad 4
Bexley 4
Biella 4
Bologna 4
Brasília 4
Cassano Magnago 4
Chengdu 4
Fairfield 4
Formigine 4
Guarulhos 4
Haiphong 4
Totale 3.430
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Nome #
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 145
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 141
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 130
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 128
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 127
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 126
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 124
La spettrometria di massa negli studi di stabilità dei farmaci 121
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 117
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 114
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 114
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 114
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 112
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 112
CBD and CBG permeation study through an artificial skin-biomimetic membrane 109
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 101
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 101
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 101
null 100
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 98
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 97
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 97
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 96
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 96
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 96
An aryne-based three-component access to α-aroylamino amides 95
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 95
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 93
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 90
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 89
Medicinal Chemistry of Isocyanides 89
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 88
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 87
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 86
Spray-drying of oil-in-gel emulsions containing cannabigerol 84
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 82
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 82
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 80
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 78
Soft drugs for dermatological applications: recent trends 78
Forced degradation study of thiocolchicoside: Characterization of its degradation products 77
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 75
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 75
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 74
Injectable medicated graft substitute active on bone tissue regeneration 74
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 73
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 73
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 72
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 71
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 71
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 70
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 69
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 68
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 68
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 68
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 67
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 67
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 67
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 65
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 64
Topical emulgels and powders containing Cannabis sativa L. extracts 63
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 61
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 60
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 58
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 58
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 51
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 47
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 46
In-water synthesis of isocyanides under micellar conditions 46
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 45
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation 18
Totale 6.074
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Categoria #
all - tutte 31.035
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.035
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021285 0 0 0 0 0 51 56 6 67 34 54 17
2021/2022484 30 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/20251.092 38 31 66 34 58 139 128 102 189 74 30 203
2025/20261.444 172 106 198 446 403 119 0 0 0 0 0 0
Totale 6.074