IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 1.805
NA - Nord America 1.357
AS - Asia 387
Continente sconosciuto - Info sul continente non disponibili 4
SA - Sud America 3
AF - Africa 1
Totale 3.557
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Nazione #
US - Stati Uniti d'America 1.347
IE - Irlanda 472
IT - Italia 434
SE - Svezia 269
DE - Germania 266
UA - Ucraina 158
CN - Cina 113
FI - Finlandia 91
SG - Singapore 85
IN - India 63
HK - Hong Kong 55
GB - Regno Unito 34
TR - Turchia 31
IR - Iran 28
CZ - Repubblica Ceca 17
BE - Belgio 16
RU - Federazione Russa 14
FR - Francia 11
CA - Canada 10
AT - Austria 5
NL - Olanda 5
EU - Europa 4
JP - Giappone 4
DK - Danimarca 3
GR - Grecia 3
ES - Italia 2
KR - Corea 2
NO - Norvegia 2
PE - Perù 2
VN - Vietnam 2
BG - Bulgaria 1
CH - Svizzera 1
CL - Cile 1
EG - Egitto 1
IQ - Iraq 1
JO - Giordania 1
LT - Lituania 1
PH - Filippine 1
PK - Pakistan 1
Totale 3.557
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Città #
Dublin 472
Jacksonville 292
Dearborn 161
Piemonte 122
Chandler 108
Wilmington 83
Ann Arbor 75
Singapore 58
Hong Kong 54
Lawrence 53
Princeton 53
Beijing 44
Bremen 36
San Mateo 31
Helsinki 29
Andover 28
Milan 28
Turin 25
Ankara 19
Novara 19
Ashburn 18
Munich 18
Brussels 16
Monmouth Junction 15
Brno 14
Hefei 14
Nanjing 12
Boardman 11
Santa Clara 11
Mülheim 10
Zola Predosa 10
Kocaeli 9
Norwalk 9
Torino 9
Ardabil 8
Dallas 8
Toronto 8
Bari 7
Leawood 7
Vercelli 7
Jinan 6
Rome 6
Sacramento 6
Seattle 6
Zanjan 6
Busto Arsizio 5
Houston 5
Straubing 5
Biella 4
Cassano Magnago 4
Chengdu 4
Fairfield 4
Formigine 4
Kunming 4
Nanchang 4
Shenyang 4
Villach 4
Woodbridge 4
Zhengzhou 4
Amsterdam 3
Athens 3
Berlin 3
Como 3
Grignasco 3
Ipswich 3
Kecioeren 3
Lyngby 3
Montesarchio 3
Nürnberg 3
Palermo 3
Prague 3
Strasbourg 3
Verona 3
Bangalore 2
Bellinzago Novarese 2
Bologna 2
Borgomanero 2
Borgomasino 2
Cerano 2
Chivasso 2
Dong Ket 2
Düsseldorf 2
Falkenstein 2
Fuzhou 2
Grafing 2
La Canada Flintridge 2
Lima 2
Lomazzo 2
Los Angeles 2
Meppel 2
Modena 2
Padova 2
Pavia 2
Phoenix 2
San Diego 2
San Francisco 2
Sesto San Giovanni 2
Shanghai 2
Stavanger 2
Velletri 2
Totale 2.196
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Nome #
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 109
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 98
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 98
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 97
La spettrometria di massa negli studi di stabilità dei farmaci 89
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 89
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 84
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 83
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 82
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 82
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 80
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 78
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 77
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 74
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 73
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 73
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 72
An aryne-based three-component access to α-aroylamino amides 68
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 67
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 64
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 64
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 64
Forced degradation study of thiocolchicoside: Characterization of its degradation products 63
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 62
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 61
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 60
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 58
CBD and CBG permeation study through an artificial skin-biomimetic membrane 56
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 56
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 56
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 55
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 54
Spray-drying of oil-in-gel emulsions containing cannabigerol 53
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 53
Soft drugs for dermatological applications: recent trends 52
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 51
Injectable medicated graft substitute active on bone tissue regeneration 51
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 51
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 51
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 51
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 51
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 49
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 48
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 46
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 46
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 45
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 44
Medicinal Chemistry of Isocyanides 44
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 42
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 42
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 41
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 41
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 40
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 40
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 39
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 37
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 32
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 30
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 28
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 27
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 27
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 22
In-water synthesis of isocyanides under micellar conditions 12
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 11
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 9
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 9
Topical emulgels and powders containing Cannabis sativa L. extracts 9
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 4
Totale 3.674
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Categoria #
all - tutte 18.561
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.561
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020591 0 0 0 4 99 115 132 28 63 67 76 7
2020/2021456 58 3 53 9 48 51 56 6 67 34 54 17
2021/2022484 30 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/2025136 38 31 66 1 0 0 0 0 0 0 0 0
Totale 3.674