IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
NA - Nord America 3.316
EU - Europa 3.284
AS - Asia 1.802
SA - Sud America 233
Continente sconosciuto - Info sul continente non disponibili 142
AF - Africa 74
OC - Oceania 3
Totale 8.854
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Nazione #
US - Stati Uniti d'America 3.177
RU - Federazione Russa 698
IT - Italia 695
SG - Singapore 530
IE - Irlanda 475
CN - Cina 442
DE - Germania 397
SE - Svezia 287
VN - Vietnam 254
HK - Hong Kong 222
BR - Brasile 173
UA - Ucraina 172
FR - Francia 135
FI - Finlandia 130
GB - Regno Unito 104
IN - India 102
CA - Canada 76
TR - Turchia 51
BD - Bangladesh 34
IR - Iran 28
NL - Olanda 28
MX - Messico 26
BJ - Benin 25
JP - Giappone 25
KR - Corea 25
EE - Estonia 24
ES - Italia 23
CZ - Repubblica Ceca 21
BE - Belgio 20
AR - Argentina 18
PL - Polonia 18
ID - Indonesia 17
IQ - Iraq 16
EC - Ecuador 13
LT - Lituania 13
AT - Austria 12
ZA - Sudafrica 10
MA - Marocco 9
PK - Pakistan 8
SA - Arabia Saudita 8
VE - Venezuela 8
CO - Colombia 7
JM - Giamaica 7
UZ - Uzbekistan 6
AE - Emirati Arabi Uniti 5
CR - Costa Rica 5
DK - Danimarca 5
EG - Egitto 5
HN - Honduras 5
KE - Kenya 5
MY - Malesia 5
TW - Taiwan 5
EU - Europa 4
JO - Giordania 4
NI - Nicaragua 4
PE - Perù 4
PH - Filippine 4
PR - Porto Rico 4
PY - Paraguay 4
SV - El Salvador 4
TH - Thailandia 4
BG - Bulgaria 3
CH - Svizzera 3
CL - Cile 3
DZ - Algeria 3
ET - Etiopia 3
GR - Grecia 3
HU - Ungheria 3
MD - Moldavia 3
RO - Romania 3
TN - Tunisia 3
AU - Australia 2
BY - Bielorussia 2
CG - Congo 2
GA - Gabon 2
GT - Guatemala 2
NO - Norvegia 2
NP - Nepal 2
RS - Serbia 2
TT - Trinidad e Tobago 2
AO - Angola 1
BB - Barbados 1
BO - Bolivia 1
BW - Botswana 1
BZ - Belize 1
CD - Congo 1
CI - Costa d'Avorio 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
DM - Dominica 1
GY - Guiana 1
IL - Israele 1
KW - Kuwait 1
LB - Libano 1
LV - Lettonia 1
LY - Libia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PA - Panama 1
PT - Portogallo 1
Totale 8.713
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Città #
Dublin 475
San Jose 352
Jacksonville 292
Singapore 221
Hong Kong 218
Ashburn 199
Council Bluffs 164
Dearborn 161
Beijing 138
Piemonte 122
Chandler 108
Wilmington 84
Novara 80
Ho Chi Minh City 78
Moscow 78
Los Angeles 77
Ann Arbor 75
Columbus 75
Munich 74
Hanoi 67
Lauterbourg 55
Milan 54
Lawrence 53
New York 53
Princeton 53
Santa Clara 50
Helsinki 48
Turin 48
Phoenix 46
Bremen 36
Dallas 36
Buffalo 35
San Mateo 31
Andover 28
Frankfurt am Main 28
São Paulo 26
Cotonou 25
Ankara 24
Montreal 23
Orem 23
Denver 22
Chennai 21
Toronto 21
Seoul 20
Turku 20
Brussels 19
Tokyo 19
Chicago 18
Falkenstein 18
Rome 18
Stockholm 17
Hefei 15
Monmouth Junction 15
Brno 14
Brooklyn 14
Mexico City 14
Redondo Beach 14
Vercelli 14
Warsaw 14
Amsterdam 13
Atlanta 13
San Francisco 13
Seattle 13
Boardman 12
Boston 12
Nanjing 12
Da Nang 11
Nuremberg 11
Tianjin 11
Guangzhou 10
Jakarta 10
Mülheim 10
Roubaix 10
Zola Predosa 10
Brasília 9
Johannesburg 9
Kocaeli 9
Norwalk 9
Poplar 9
Schaumburg 9
Torino 9
Ardabil 8
Borgomanero 8
Chengdu 8
Florence 8
Manchester 8
North Bergen 8
Shanghai 8
Bari 7
Biên Hòa 7
Haiphong 7
Hangzhou 7
Houston 7
Leawood 7
London 7
Philadelphia 7
Prague 7
Sacramento 7
Baghdad 6
Bologna 6
Totale 4.612
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Nome #
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 188
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 187
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 183
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 174
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 171
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 166
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 165
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 164
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 164
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 158
CBD and CBG permeation study through an artificial skin-biomimetic membrane 157
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 157
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 157
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 155
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 154
La spettrometria di massa negli studi di stabilità dei farmaci 152
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 148
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 147
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 146
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 145
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 145
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 143
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 140
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 140
Medicinal Chemistry of Isocyanides 139
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 138
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 136
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 133
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 132
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 128
An aryne-based three-component access to α-aroylamino amides 126
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 125
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 123
Spray-drying of oil-in-gel emulsions containing cannabigerol 122
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 122
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 121
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 118
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 118
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 118
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 117
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 114
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 114
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 113
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 112
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 110
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 110
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 108
Forced degradation study of thiocolchicoside: Characterization of its degradation products 108
Soft drugs for dermatological applications: recent trends 104
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 104
Injectable medicated graft substitute active on bone tissue regeneration 103
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 101
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 101
Topical emulgels and powders containing Cannabis sativa L. extracts 100
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 99
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 99
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 94
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 93
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 93
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 92
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 91
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 87
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 84
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 83
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 83
In-water synthesis of isocyanides under micellar conditions 82
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 80
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 79
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 77
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation 71
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 69
Bacillus subtilis AC7 Fermentation on Rice Husk Substrate: A Sustainable Approach for Lipopeptide Biosurfactant Production 39
Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling 35
Totale 8.854
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Categoria #
all - tutte 40.233
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.233
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022390 0 0 0 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/20251.074 38 31 66 34 58 139 128 94 185 72 30 199
2025/20263.278 166 103 192 442 395 219 401 556 200 320 205 79
2026/2027964 153 299 225 287 0 0 0 0 0 0 0 0
Totale 8.854