IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 3.212
NA - Nord America 2.819
AS - Asia 1.795
SA - Sud America 224
Continente sconosciuto - Info sul continente non disponibili 140
AF - Africa 71
OC - Oceania 3
Totale 8.264
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Nazione #
US - Stati Uniti d'America 2.724
RU - Federazione Russa 698
IT - Italia 662
SG - Singapore 529
IE - Irlanda 475
CN - Cina 441
DE - Germania 394
SE - Svezia 287
VN - Vietnam 254
HK - Hong Kong 220
UA - Ucraina 172
BR - Brasile 167
FI - Finlandia 130
FR - Francia 124
IN - India 102
GB - Regno Unito 87
CA - Canada 53
TR - Turchia 51
BD - Bangladesh 33
IR - Iran 28
NL - Olanda 27
BJ - Benin 25
JP - Giappone 25
KR - Corea 25
MX - Messico 24
ES - Italia 23
EE - Estonia 22
CZ - Repubblica Ceca 21
BE - Belgio 19
AR - Argentina 17
PL - Polonia 17
ID - Indonesia 16
IQ - Iraq 16
EC - Ecuador 13
LT - Lituania 13
AT - Austria 12
ZA - Sudafrica 10
MA - Marocco 9
PK - Pakistan 8
SA - Arabia Saudita 8
VE - Venezuela 8
UZ - Uzbekistan 6
AE - Emirati Arabi Uniti 5
CO - Colombia 5
EG - Egitto 5
KE - Kenya 5
TW - Taiwan 5
DK - Danimarca 4
EU - Europa 4
JM - Giamaica 4
JO - Giordania 4
MY - Malesia 4
PE - Perù 4
PH - Filippine 4
PY - Paraguay 4
TH - Thailandia 4
BG - Bulgaria 3
CH - Svizzera 3
CL - Cile 3
DZ - Algeria 3
ET - Etiopia 3
GR - Grecia 3
MD - Moldavia 3
RO - Romania 3
SV - El Salvador 3
AU - Australia 2
BY - Bielorussia 2
GA - Gabon 2
GT - Guatemala 2
NO - Norvegia 2
NP - Nepal 2
RS - Serbia 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AO - Angola 1
BO - Bolivia 1
BW - Botswana 1
BZ - Belize 1
CD - Congo 1
CG - Congo 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
GY - Guiana 1
HN - Honduras 1
HU - Ungheria 1
IL - Israele 1
KW - Kuwait 1
LB - Libano 1
LV - Lettonia 1
NG - Nigeria 1
NI - Nicaragua 1
NZ - Nuova Zelanda 1
PA - Panama 1
PR - Porto Rico 1
PT - Portogallo 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
SX - ???statistics.table.value.countryCode.SX??? 1
Totale 8.127
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Città #
Dublin 475
Jacksonville 292
San Jose 263
Singapore 220
Hong Kong 217
Ashburn 183
Dearborn 161
Council Bluffs 145
Beijing 138
Piemonte 122
Chandler 108
Wilmington 83
Novara 80
Ho Chi Minh City 78
Moscow 78
Ann Arbor 75
Columbus 75
Munich 74
Los Angeles 73
Hanoi 67
Lauterbourg 55
Lawrence 53
Princeton 53
Helsinki 48
New York 46
Turin 45
Milan 44
Santa Clara 40
Bremen 36
Buffalo 31
San Mateo 31
Dallas 30
Andover 28
Frankfurt am Main 28
São Paulo 26
Cotonou 25
Ankara 24
Orem 23
Chennai 21
Seoul 20
Turku 20
Brussels 19
Tokyo 19
Falkenstein 18
Montreal 18
Rome 17
Stockholm 17
Toronto 17
Hefei 15
Monmouth Junction 15
Phoenix 15
Brno 14
Chicago 14
Mexico City 14
Redondo Beach 14
Vercelli 14
Amsterdam 13
Denver 13
Warsaw 13
Boardman 12
Nanjing 12
San Francisco 12
Seattle 12
Boston 11
Da Nang 11
Nuremberg 11
Tianjin 11
Atlanta 10
Guangzhou 10
Jakarta 10
Mülheim 10
Roubaix 10
Zola Predosa 10
Johannesburg 9
Kocaeli 9
Norwalk 9
Poplar 9
Torino 9
Ardabil 8
Borgomanero 8
Chengdu 8
Manchester 8
Bari 7
Biên Hòa 7
Brooklyn 7
Florence 7
Haiphong 7
Hangzhou 7
Houston 7
Leawood 7
London 7
Prague 7
Sacramento 7
Shanghai 7
Baghdad 6
Bologna 6
Hillsboro 6
Jinan 6
Tashkent 6
Verona 6
Totale 4.362
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Nome #
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 181
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 176
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 173
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 168
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 164
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 162
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 157
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 157
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 150
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 150
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 149
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 148
CBD and CBG permeation study through an artificial skin-biomimetic membrane 147
La spettrometria di massa negli studi di stabilità dei farmaci 147
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 143
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 143
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 140
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 138
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 134
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 132
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 131
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 131
Medicinal Chemistry of Isocyanides 131
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 130
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 127
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 127
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 126
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 126
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 123
An aryne-based three-component access to α-aroylamino amides 123
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 122
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 120
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 116
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 115
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 114
Spray-drying of oil-in-gel emulsions containing cannabigerol 113
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 112
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 112
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 111
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 110
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 108
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 107
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 106
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 105
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 104
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 104
Forced degradation study of thiocolchicoside: Characterization of its degradation products 103
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 99
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 98
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 98
Soft drugs for dermatological applications: recent trends 98
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 96
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 96
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 95
Injectable medicated graft substitute active on bone tissue regeneration 95
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 92
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 91
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 90
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 89
Topical emulgels and powders containing Cannabis sativa L. extracts 89
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 86
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 83
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 81
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 80
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 80
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 77
In-water synthesis of isocyanides under micellar conditions 73
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 72
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 68
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 59
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation 52
Bacillus subtilis AC7 Fermentation on Rice Husk Substrate: A Sustainable Approach for Lipopeptide Biosurfactant Production 11
Totale 8.264
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Categoria #
all - tutte 37.571
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.571
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022454 0 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/20251.074 38 31 66 34 58 139 128 94 185 72 30 199
2025/20263.278 166 103 192 442 395 219 401 556 200 320 205 79
2026/2027374 153 221 0 0 0 0 0 0 0 0 0 0
Totale 8.264