IRIS
APRILE, SILVIO
 Distribuzione geografica
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Continente #
EU - Europa 3.183
NA - Nord America 2.336
AS - Asia 1.676
SA - Sud America 219
AF - Africa 70
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
Totale 7.491
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Nazione #
US - Stati Uniti d'America 2.260
RU - Federazione Russa 704
IT - Italia 635
IE - Irlanda 475
SG - Singapore 462
CN - Cina 411
DE - Germania 397
SE - Svezia 286
VN - Vietnam 258
HK - Hong Kong 215
UA - Ucraina 171
BR - Brasile 165
FI - Finlandia 131
FR - Francia 127
IN - India 100
GB - Regno Unito 85
TR - Turchia 50
CA - Canada 43
IR - Iran 28
BJ - Benin 25
NL - Olanda 25
EE - Estonia 24
JP - Giappone 24
KR - Corea 24
MX - Messico 23
ES - Italia 20
BD - Bangladesh 19
BE - Belgio 19
AR - Argentina 18
CZ - Repubblica Ceca 18
IQ - Iraq 16
PL - Polonia 16
ID - Indonesia 15
EC - Ecuador 14
LT - Lituania 13
AT - Austria 12
ZA - Sudafrica 10
MA - Marocco 9
PK - Pakistan 9
SA - Arabia Saudita 8
VE - Venezuela 8
UZ - Uzbekistan 7
KE - Kenya 5
TW - Taiwan 5
AE - Emirati Arabi Uniti 4
DK - Danimarca 4
EG - Egitto 4
EU - Europa 4
JO - Giordania 4
PE - Perù 4
PH - Filippine 4
PY - Paraguay 4
BG - Bulgaria 3
CH - Svizzera 3
CL - Cile 3
DZ - Algeria 3
ET - Etiopia 3
GR - Grecia 3
MY - Malesia 3
RO - Romania 3
TH - Thailandia 3
AU - Australia 2
BY - Bielorussia 2
GA - Gabon 2
GT - Guatemala 2
NO - Norvegia 2
NP - Nepal 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AO - Angola 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CG - Congo 1
CI - Costa d'Avorio 1
CO - Colombia 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
HN - Honduras 1
HU - Ungheria 1
IL - Israele 1
JM - Giamaica 1
KW - Kuwait 1
LB - Libano 1
LV - Lettonia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PA - Panama 1
PT - Portogallo 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
SV - El Salvador 1
SY - Repubblica araba siriana 1
UY - Uruguay 1
Totale 7.491
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Città #
Dublin 475
Jacksonville 292
Singapore 218
San Jose 213
Hong Kong 212
Ashburn 167
Dearborn 161
Beijing 140
Piemonte 122
Chandler 108
Novara 86
Wilmington 83
Ho Chi Minh City 79
Moscow 79
Munich 77
Ann Arbor 75
Hanoi 69
Los Angeles 69
Lauterbourg 55
Lawrence 53
Princeton 53
Helsinki 48
Turin 43
Milan 42
New York 37
Bremen 36
Buffalo 32
San Mateo 31
Andover 28
Frankfurt am Main 28
São Paulo 26
Cotonou 25
Ankara 24
Orem 22
Chennai 21
Turku 21
Dallas 20
Santa Clara 20
Seoul 20
Brussels 19
Tokyo 19
Council Bluffs 18
Falkenstein 18
Montreal 16
Stockholm 16
Toronto 16
Hefei 15
Monmouth Junction 15
Vercelli 15
Brno 14
Redondo Beach 14
Rome 14
Amsterdam 13
Warsaw 13
Mexico City 12
Nanjing 12
Boardman 11
Da Nang 11
Denver 11
Nuremberg 11
Roubaix 11
Seattle 11
Tianjin 11
Atlanta 10
Guangzhou 10
Jakarta 10
Mülheim 10
Zola Predosa 10
Boston 9
Johannesburg 9
Kocaeli 9
Norwalk 9
Poplar 9
Torino 9
Ardabil 8
Borgomanero 8
Chengdu 8
Chicago 8
Phoenix 8
Bari 7
Biên Hòa 7
Florence 7
Haiphong 7
Hillsboro 7
Houston 7
Leawood 7
London 7
Manchester 7
San Francisco 7
Tashkent 7
Baghdad 6
Brooklyn 6
Jinan 6
Sacramento 6
Verona 6
Zanjan 6
Barnet 5
Brasília 5
Busto Arsizio 5
Mumbai 5
Totale 4.023
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Nome #
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 171
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 165
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 161
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 158
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 154
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites 151
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 151
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 147
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products 145
La spettrometria di massa negli studi di stabilità dei farmaci 141
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 138
CBD and CBG permeation study through an artificial skin-biomimetic membrane 137
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE-CONTAINING DRUGS 135
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue 135
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 133
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 131
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment 130
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 126
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 125
CHEMICAL STABILITY STUDIES OF PROPARGYLAMINE CONTAINING-DRUGS 122
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 122
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer 120
Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study 119
An aryne-based three-component access to α-aroylamino amides 119
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 118
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 116
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation 115
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 115
Medicinal Chemistry of Isocyanides 114
New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement 113
DEVELOPMENT AND VALIDATION OF HPLC-UV STABILITY INDICATING METHOD FOR THE DETERMINATION OF THIOCOLCHICOSIDE AND ITS DEGRADATION PRODUCTS IN PHARMACEUTICAL DOSAGE FORM 112
Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects 112
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products 109
Spray-drying of oil-in-gel emulsions containing cannabigerol 108
Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction 106
Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate 106
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT LIVER MICROSOMES 102
null 100
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 98
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics 98
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 95
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 94
Forced degradation study of thiocolchicoside: Characterization of its degradation products 93
Role of chocolate consumption in the inflammatory pathway: a proteomic approach 93
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 92
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 92
Soft drugs for dermatological applications: recent trends 92
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 91
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite 91
Injectable medicated graft substitute active on bone tissue regeneration 91
FORCED DEGRADATION STUDY OF OXYBUTYNIN: NEW INSIGHTS FROM LC-MS/MS ANALYSIS ON ITS CHEMICAL STABILITY 88
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 87
IN VITRO METABOLISM OF ALIZAPRIDE: EVIDENCE FOR THE FORMATION OF ACROLEIN IN RAT LIVER MICROSOMES 85
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 85
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF A SULPHATE CONJUGATE METABOLITE 84
IN VITRO, IN VIVO METABOLISM STUDY OF COMBRETASTATIN A-4 IN RAT AND HUMAN 83
In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry 82
LC-MS CHARACTERIZATION OF THE IN VITRO METABOLITES OF ALIZAPRIDE 82
Topical emulgels and powders containing Cannabis sativa L. extracts 81
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 79
Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4. Drug Metabolism and Disposition 79
New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study 78
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 75
In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: Evidence for the formation of an epoxide metabolite 75
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 72
The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. 71
In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite 71
Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration 64
IN VITRO METABOLISM STUDY OF ISOPROPYL-9H-THIOXANTHEN-9-ONE (ITX) IN RAT AND HUMAN LIVER MICROSOMES 63
In-water synthesis of isocyanides under micellar conditions 58
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation 42
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 38
Totale 7.624
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Categoria #
all - tutte 33.718
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.718
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021105 0 0 0 0 0 0 0 0 0 34 54 17
2021/2022484 30 24 40 62 31 4 39 9 26 63 55 101
2022/20231.095 70 46 66 22 81 93 45 75 490 21 53 33
2023/2024390 33 30 42 22 60 2 60 16 7 15 45 58
2024/20251.092 38 31 66 34 58 139 128 102 189 74 30 203
2025/20262.994 172 106 198 446 403 222 411 563 205 268 0 0
Totale 7.624