IRIS
TRON, Gian Cesare
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 5.575
NA - Nord America 5.567
AS - Asia 3.519
SA - Sud America 565
Continente sconosciuto - Info sul continente non disponibili 246
AF - Africa 83
OC - Oceania 3
Totale 15.558
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 5.402
RU - Federazione Russa 1.335
SG - Singapore 1.180
IE - Irlanda 1.065
CN - Cina 818
IT - Italia 700
DE - Germania 697
SE - Svezia 519
HK - Hong Kong 486
VN - Vietnam 448
BR - Brasile 425
UA - Ucraina 395
FI - Finlandia 256
FR - Francia 229
IN - India 198
GB - Regno Unito 127
CA - Canada 99
TR - Turchia 99
EE - Estonia 59
AR - Argentina 54
BD - Bangladesh 46
ID - Indonesia 35
MX - Messico 33
KR - Corea 32
PL - Polonia 32
IR - Iran 28
ES - Italia 27
CZ - Repubblica Ceca 26
BJ - Benin 25
JP - Giappone 25
BE - Belgio 23
AT - Austria 22
EC - Ecuador 22
IQ - Iraq 22
ZA - Sudafrica 21
NL - Olanda 20
PK - Pakistan 19
LT - Lituania 16
CL - Cile 15
VE - Venezuela 14
CO - Colombia 13
TH - Thailandia 9
AE - Emirati Arabi Uniti 8
EU - Europa 8
MA - Marocco 8
UZ - Uzbekistan 8
HN - Honduras 7
PE - Perù 7
PH - Filippine 7
SA - Arabia Saudita 7
TN - Tunisia 7
AZ - Azerbaigian 6
DZ - Algeria 6
JM - Giamaica 6
JO - Giordania 6
KE - Kenya 6
PY - Paraguay 6
TT - Trinidad e Tobago 6
IL - Israele 5
UY - Uruguay 5
BO - Bolivia 4
CR - Costa Rica 4
DK - Danimarca 4
GR - Grecia 4
KZ - Kazakistan 4
MY - Malesia 4
AU - Australia 3
DO - Repubblica Dominicana 3
EG - Egitto 3
LB - Libano 3
MD - Moldavia 3
NP - Nepal 3
OM - Oman 3
PA - Panama 3
BG - Bulgaria 2
CH - Svizzera 2
GA - Gabon 2
KG - Kirghizistan 2
MM - Myanmar 2
NI - Nicaragua 2
RO - Romania 2
RS - Serbia 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AL - Albania 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BW - Botswana 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
ET - Etiopia 1
GE - Georgia 1
GP - Guadalupe 1
HU - Ungheria 1
KW - Kuwait 1
KY - Cayman, isole 1
LV - Lettonia 1
PT - Portogallo 1
Totale 15.321
Salva come PNG Salva come JPEG
Città #
Dublin 1.064
Jacksonville 715
Hong Kong 484
San Jose 468
Singapore 397
Dearborn 373
Ashburn 310
Council Bluffs 265
Beijing 259
Chandler 195
Moscow 182
Wilmington 182
Piemonte 174
Ann Arbor 161
Columbus 141
Ho Chi Minh City 133
Lawrence 133
Princeton 133
Lauterbourg 131
Los Angeles 126
Hanoi 104
Munich 95
San Mateo 95
New York 84
Buffalo 75
Santa Clara 71
Andover 66
São Paulo 57
Dallas 55
Novara 55
Helsinki 47
Bremen 44
Ankara 43
Frankfurt am Main 38
Milan 38
Toronto 38
Redondo Beach 37
Phoenix 32
Orem 30
Chennai 28
Montreal 28
Seoul 28
Hefei 26
Houston 26
Monmouth Junction 26
Turku 26
Cotonou 25
Kecioeren 25
Brno 24
Atlanta 23
Boston 23
Warsaw 23
Brooklyn 22
London 22
Tokyo 20
Chicago 19
Da Nang 19
Denver 19
Haiphong 19
Nanjing 19
Tianjin 19
Kocaeli 18
Brussels 17
Seattle 17
The Dalles 17
Woodbridge 17
Guangzhou 16
Norwalk 16
Poplar 16
Stockholm 16
Hangzhou 15
Johannesburg 15
Kunming 14
Rio de Janeiro 14
Fairfield 13
Jinan 13
Nuremberg 13
Philadelphia 13
Turin 13
Boardman 12
Nanchang 12
Campinas 11
Formigine 11
Torino 11
Vienna 11
Berlin 10
Brasília 10
Can Tho 10
Hillsboro 10
Mexico City 10
Shanghai 10
Shenzhen 10
Zanjan 10
Amsterdam 9
Bexley 9
Biên Hòa 9
Falkenstein 9
Grafing 9
Leawood 9
Mumbai 9
Totale 8.123
Salva come PNG Salva come JPEG
Nome #
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 335
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 280
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 245
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 196
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 192
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 181
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 180
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 176
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 168
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 164
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 164
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 157
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 146
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 145
Combretabenzodiazepines: a novel class of antitubulin agents 141
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 140
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 139
Estrogenic analogues synthesized by click chemistry 136
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 136
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 134
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 134
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 134
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 132
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 132
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 131
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 131
Medicinal Chemistry of Isocyanides 131
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 129
A concise entry into nonsymmetrical alkyl polyamines 127
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 127
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 127
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 126
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 124
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 123
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 122
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 119
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 119
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 118
A Concise Entry into Nonsymmetrical Alkyl Polyamines 117
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 117
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 117
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 115
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 115
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 115
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 114
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 113
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 112
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 112
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 111
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 111
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 111
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 111
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 111
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 110
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 110
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 109
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 109
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 109
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 108
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 107
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 106
Chemoselective esterification of phenolic acids and alcohols 106
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction 105
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 105
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 105
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 105
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 104
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 103
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 101
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 101
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 101
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 100
An efficient synthesis of symmetric and unsymmetric bis-(ß-aminoamides) via Ugi multicomponent reaction. 99
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 98
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 98
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 98
Icilio Guareschi and his amazing “1897 reaction” 98
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions 97
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 97
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 96
Sintesi e caratterizzazione di nuovi inibitori di DGKα 96
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 96
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 96
Synthesis and biological evaluation of combretatriazoles 94
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 93
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 93
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 92
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 91
The Nef reaction of isocyanides 91
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 90
Exploiting the Different Nucleophilicity of the Isocyano Group: A Strategy for the Isocyanide Functionalization 89
New potential uroselective NO-donor alpha 1 antagonist 89
“Synthesis and biological evaluation of triazole analogues of FK866, a potent inhibitor of human Nicotinamide Phosphoribosyltransferase” 89
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans 89
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 87
NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties 86
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives 85
Pietro Biginelli: The man behind the reaction 84
Synthesis and cytotoxic evaluation of combretafurazans 83
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 82
Totale 12.123
Salva come PNG Salva come JPEG
Categoria #
all - tutte 75.970
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 75.970
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022879 0 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/20251.939 31 32 109 27 53 205 190 162 402 183 159 386
2025/20265.655 270 190 455 863 585 361 735 940 329 510 294 123
2026/2027842 442 400 0 0 0 0 0 0 0 0 0 0
Totale 15.558