IRIS
TRON, Gian Cesare
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 5.533
NA - Nord America 4.433
AS - Asia 3.369
SA - Sud America 552
AF - Africa 83
Continente sconosciuto - Info sul continente non disponibili 10
OC - Oceania 3
Totale 13.983
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 4.309
RU - Federazione Russa 1.334
SG - Singapore 1.095
IE - Irlanda 1.064
CN - Cina 779
DE - Germania 696
IT - Italia 674
SE - Svezia 519
HK - Hong Kong 478
VN - Vietnam 447
BR - Brasile 420
UA - Ucraina 395
FI - Finlandia 256
FR - Francia 228
IN - India 198
GB - Regno Unito 124
TR - Turchia 99
CA - Canada 82
EE - Estonia 59
AR - Argentina 51
BD - Bangladesh 41
ID - Indonesia 33
KR - Corea 31
PL - Polonia 30
MX - Messico 29
IR - Iran 28
CZ - Repubblica Ceca 26
ES - Italia 26
BJ - Benin 25
BE - Belgio 23
AT - Austria 22
IQ - Iraq 22
JP - Giappone 21
ZA - Sudafrica 21
EC - Ecuador 20
PK - Pakistan 19
NL - Olanda 18
LT - Lituania 16
CL - Cile 15
VE - Venezuela 14
CO - Colombia 10
TH - Thailandia 9
AE - Emirati Arabi Uniti 8
EU - Europa 8
MA - Marocco 8
PE - Perù 7
PH - Filippine 7
SA - Arabia Saudita 7
TN - Tunisia 7
UZ - Uzbekistan 7
AZ - Azerbaigian 6
DZ - Algeria 6
JO - Giordania 6
KE - Kenya 6
PY - Paraguay 6
IL - Israele 5
UY - Uruguay 5
BO - Bolivia 4
DK - Danimarca 4
GR - Grecia 4
KZ - Kazakistan 4
AU - Australia 3
DO - Repubblica Dominicana 3
EG - Egitto 3
HN - Honduras 3
LB - Libano 3
MD - Moldavia 3
NP - Nepal 3
OM - Oman 3
PA - Panama 3
TT - Trinidad e Tobago 3
CH - Svizzera 2
GA - Gabon 2
KG - Kirghizistan 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AL - Albania 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BW - Botswana 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
ET - Etiopia 1
GE - Georgia 1
HU - Ungheria 1
JM - Giamaica 1
KW - Kuwait 1
LV - Lettonia 1
MM - Myanmar 1
MY - Malesia 1
PT - Portogallo 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
ZM - Zambia 1
Totale 13.983
Salva come PNG Salva come JPEG
Città #
Dublin 1.064
Jacksonville 712
Hong Kong 476
Singapore 378
Dearborn 373
San Jose 371
Ashburn 263
Beijing 254
Chandler 195
Moscow 182
Wilmington 180
Piemonte 174
Ann Arbor 161
Lawrence 133
Princeton 133
Ho Chi Minh City 132
Lauterbourg 131
Hanoi 104
Los Angeles 102
Munich 95
San Mateo 95
Buffalo 75
Andover 66
New York 58
São Paulo 56
Novara 55
Helsinki 47
Bremen 44
Ankara 43
Santa Clara 43
Dallas 42
Frankfurt am Main 38
Milan 37
Redondo Beach 37
Toronto 32
Chennai 28
Montreal 28
Orem 28
Seoul 28
Hefei 26
Monmouth Junction 26
Turku 26
Cotonou 25
Kecioeren 25
Brno 24
Houston 24
Warsaw 22
London 21
Da Nang 19
Haiphong 19
Nanjing 19
Tianjin 19
Tokyo 19
Boston 18
Kocaeli 18
Brussels 17
Woodbridge 17
Atlanta 16
Chicago 16
Guangzhou 16
Norwalk 16
Poplar 16
Seattle 16
Stockholm 16
Johannesburg 15
Brooklyn 14
Kunming 14
Rio de Janeiro 14
Denver 13
Fairfield 13
Jinan 13
Nuremberg 13
Phoenix 13
Turin 13
Boardman 12
Nanchang 12
Council Bluffs 11
Formigine 11
Hangzhou 11
Torino 11
Vienna 11
Berlin 10
Brasília 10
Campinas 10
Can Tho 10
Hillsboro 10
Shenzhen 10
Zanjan 10
Amsterdam 9
Bexley 9
Biên Hòa 9
Falkenstein 9
Grafing 9
Leawood 9
Mumbai 9
Baghdad 8
Dong Ket 8
Mexico City 8
Montesarchio 8
Vercelli 8
Totale 7.376
Salva come PNG Salva come JPEG
Nome #
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 275
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 229
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 189
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 187
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 171
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 166
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 165
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 161
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 158
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 151
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 150
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 136
Combretabenzodiazepines: a novel class of antitubulin agents 135
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 131
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 130
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 129
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 129
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 128
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 128
Estrogenic analogues synthesized by click chemistry 127
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 126
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 126
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 125
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 125
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 123
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 121
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 120
A concise entry into nonsymmetrical alkyl polyamines 119
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 118
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 118
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 118
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 116
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 114
Medicinal Chemistry of Isocyanides 114
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 113
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 112
A Concise Entry into Nonsymmetrical Alkyl Polyamines 111
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 111
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 110
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 109
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 107
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 107
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 106
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 105
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 105
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 104
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 104
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 103
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 103
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 103
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 102
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 102
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 102
Chemoselective esterification of phenolic acids and alcohols 101
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 101
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 101
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 101
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 100
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 100
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 98
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 98
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 98
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 98
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 98
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 96
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 94
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 94
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction 93
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 93
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 93
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 93
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 92
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 92
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 91
An efficient synthesis of symmetric and unsymmetric bis-(ß-aminoamides) via Ugi multicomponent reaction. 91
Sintesi e caratterizzazione di nuovi inibitori di DGKα 91
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 91
Synthesis and biological evaluation of combretatriazoles 90
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 89
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 88
New potential uroselective NO-donor alpha 1 antagonist 87
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 87
The Nef reaction of isocyanides 87
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 87
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 86
Icilio Guareschi and his amazing “1897 reaction” 86
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions 85
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 85
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 84
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 84
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 83
“Synthesis and biological evaluation of triazole analogues of FK866, a potent inhibitor of human Nicotinamide Phosphoribosyltransferase” 83
NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties 82
Pietro Biginelli: The man behind the reaction 80
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 79
“Identification of the first selective Sirt3 inhibitor”, 79
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans 79
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives 79
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 78
Synthesis and cytotoxic evaluation of combretafurazans 77
Totale 11.099
Salva come PNG Salva come JPEG
Categoria #
all - tutte 68.322
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 68.322
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021198 0 0 0 0 0 0 0 0 0 50 130 18
2021/2022927 48 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/20251.939 31 32 109 27 53 205 190 162 402 183 159 386
2025/20265.158 270 190 455 863 585 361 735 940 329 430 0 0
Totale 14.219