IRIS
TRON, Gian Cesare
 Distribuzione geografica
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Continente #
NA - Nord America 6.359
EU - Europa 5.661
AS - Asia 3.537
SA - Sud America 572
Continente sconosciuto - Info sul continente non disponibili 250
AF - Africa 83
OC - Oceania 3
Totale 16.465
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Nazione #
US - Stati Uniti d'America 6.098
RU - Federazione Russa 1.336
SG - Singapore 1.181
IE - Irlanda 1.065
CN - Cina 821
IT - Italia 739
DE - Germania 701
SE - Svezia 520
HK - Hong Kong 491
VN - Vietnam 448
BR - Brasile 430
UA - Ucraina 397
FI - Finlandia 256
FR - Francia 238
IN - India 198
GB - Regno Unito 145
CA - Canada 141
TR - Turchia 99
EE - Estonia 65
AR - Argentina 54
BD - Bangladesh 47
MX - Messico 37
ID - Indonesia 36
PL - Polonia 33
KR - Corea 32
IR - Iran 28
ES - Italia 27
CZ - Repubblica Ceca 26
JP - Giappone 26
BJ - Benin 25
EC - Ecuador 24
BE - Belgio 23
AT - Austria 22
IQ - Iraq 22
ZA - Sudafrica 21
NL - Olanda 20
PK - Pakistan 19
HN - Honduras 18
LT - Lituania 17
JM - Giamaica 16
CL - Cile 15
VE - Venezuela 14
CO - Colombia 13
CR - Costa Rica 9
IL - Israele 9
TH - Thailandia 9
AE - Emirati Arabi Uniti 8
DK - Danimarca 8
EU - Europa 8
MA - Marocco 8
NI - Nicaragua 8
SA - Arabia Saudita 8
UZ - Uzbekistan 8
PE - Perù 7
PH - Filippine 7
TN - Tunisia 7
AZ - Azerbaigian 6
DZ - Algeria 6
GP - Guadalupe 6
JO - Giordania 6
KE - Kenya 6
PY - Paraguay 6
TT - Trinidad e Tobago 6
UY - Uruguay 5
BO - Bolivia 4
GR - Grecia 4
KZ - Kazakistan 4
MY - Malesia 4
SV - El Salvador 4
AU - Australia 3
CW - ???statistics.table.value.countryCode.CW??? 3
DO - Repubblica Dominicana 3
EG - Egitto 3
GT - Guatemala 3
LB - Libano 3
MD - Moldavia 3
NP - Nepal 3
OM - Oman 3
PA - Panama 3
PR - Porto Rico 3
BG - Bulgaria 2
CH - Svizzera 2
GA - Gabon 2
KG - Kirghizistan 2
KW - Kuwait 2
MM - Myanmar 2
RO - Romania 2
RS - Serbia 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AL - Albania 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BS - Bahamas 1
BW - Botswana 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
Totale 16.220
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Città #
Dublin 1.065
Jacksonville 716
San Jose 564
Hong Kong 489
Singapore 398
Dearborn 373
Ashburn 333
Council Bluffs 293
Beijing 260
Chandler 195
Wilmington 185
Moscow 182
Piemonte 174
Ann Arbor 161
Columbus 152
Ho Chi Minh City 133
Lawrence 133
Los Angeles 133
Princeton 133
Lauterbourg 131
Hanoi 104
Munich 95
New York 95
San Mateo 95
Santa Clara 88
Buffalo 81
Phoenix 69
Dallas 68
Andover 66
São Paulo 57
Novara 55
Helsinki 47
Toronto 47
Bremen 44
Ankara 43
Milan 41
Frankfurt am Main 38
Redondo Beach 37
Montreal 32
Orem 32
Chicago 31
Houston 29
Atlanta 28
Chennai 28
Denver 28
Seoul 28
North Bergen 27
Brooklyn 26
Hefei 26
Monmouth Junction 26
Turku 26
Cotonou 25
Kecioeren 25
Boston 24
Brno 24
Warsaw 24
London 22
Tokyo 21
Philadelphia 20
Da Nang 19
Haiphong 19
Nanjing 19
Seattle 19
Tianjin 19
Kocaeli 18
Brussels 17
Stockholm 17
The Dalles 17
Woodbridge 17
Guangzhou 16
Norwalk 16
Poplar 16
Hangzhou 15
Johannesburg 15
Rio de Janeiro 15
Turin 15
Kunming 14
Fairfield 13
Jinan 13
Nuremberg 13
Boardman 12
Brasília 12
Mexico City 12
Nanchang 12
Rome 12
Campinas 11
Formigine 11
Las Vegas 11
Shanghai 11
Torino 11
Vienna 11
Berlin 10
Can Tho 10
Hillsboro 10
Quito 10
Shenzhen 10
Zanjan 10
Amsterdam 9
Bexley 9
Biên Hòa 9
Totale 8.480
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Nome #
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 348
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 285
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 252
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 206
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 200
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 189
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 188
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 188
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 176
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 174
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 174
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 167
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 159
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 150
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 149
Combretabenzodiazepines: a novel class of antitubulin agents 148
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 144
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 144
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 144
Estrogenic analogues synthesized by click chemistry 143
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 143
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 140
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 139
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 139
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 139
Medicinal Chemistry of Isocyanides 139
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 137
A concise entry into nonsymmetrical alkyl polyamines 135
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 135
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 135
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 132
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 132
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 130
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 130
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 128
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 127
A Concise Entry into Nonsymmetrical Alkyl Polyamines 125
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 125
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 125
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 124
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 123
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 123
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 123
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 122
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 122
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 121
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 118
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 118
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 117
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 117
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 117
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction 116
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 116
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 115
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 115
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 114
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 114
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 114
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 114
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 113
Icilio Guareschi and his amazing “1897 reaction” 113
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 112
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 112
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 112
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 112
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 112
Chemoselective esterification of phenolic acids and alcohols 109
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 109
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 108
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 107
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 107
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 106
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 105
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 104
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 104
An efficient synthesis of symmetric and unsymmetric bis-(ß-aminoamides) via Ugi multicomponent reaction. 103
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 101
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 101
Exploiting the Different Nucleophilicity of the Isocyano Group: A Strategy for the Isocyanide Functionalization 100
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 100
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 100
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 100
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions 99
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 98
Synthesis and biological evaluation of combretatriazoles 98
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 97
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 97
Sintesi e caratterizzazione di nuovi inibitori di DGKα 97
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 95
The Nef reaction of isocyanides 94
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 93
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 93
“Synthesis and biological evaluation of triazole analogues of FK866, a potent inhibitor of human Nicotinamide Phosphoribosyltransferase” 93
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives 93
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans 91
New potential uroselective NO-donor alpha 1 antagonist 90
Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions 89
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 89
Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction 88
NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties 87
Totale 12.757
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Categoria #
all - tutte 80.777
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.777
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022746 0 0 0 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/20251.939 31 32 109 27 53 205 190 162 402 183 159 386
2025/20265.655 270 190 455 863 585 361 735 940 329 510 294 123
2026/20271.749 442 510 337 460 0 0 0 0 0 0 0 0
Totale 16.465