IRIS
TRON, Gian Cesare
 Distribuzione geografica
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Continente #
EU - Europa 3.383
NA - Nord America 2.813
AS - Asia 764
Continente sconosciuto - Info sul continente non disponibili 8
SA - Sud America 3
Totale 6.971
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Nazione #
US - Stati Uniti d'America 2.781
IE - Irlanda 1.061
IT - Italia 570
DE - Germania 514
SE - Svezia 502
UA - Ucraina 373
CN - Cina 244
FI - Finlandia 210
IN - India 134
SG - Singapore 129
HK - Hong Kong 128
TR - Turchia 78
GB - Regno Unito 39
CA - Canada 31
FR - Francia 31
IR - Iran 27
CZ - Repubblica Ceca 25
BE - Belgio 14
RU - Federazione Russa 13
VN - Vietnam 9
EU - Europa 8
NL - Olanda 7
AT - Austria 4
LT - Lituania 4
TH - Thailandia 4
BR - Brasile 3
DK - Danimarca 3
ES - Italia 3
GR - Grecia 3
IL - Israele 3
EE - Estonia 2
PH - Filippine 2
PK - Pakistan 2
BG - Bulgaria 1
HN - Honduras 1
JO - Giordania 1
JP - Giappone 1
KR - Corea 1
MD - Moldavia 1
PL - Polonia 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
SY - Repubblica araba siriana 1
Totale 6.971
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Città #
Dublin 1.061
Jacksonville 711
Dearborn 373
Chandler 195
Wilmington 180
Piemonte 174
Ann Arbor 161
Lawrence 133
Princeton 133
Hong Kong 128
Beijing 99
San Mateo 95
Singapore 73
Andover 66
Ashburn 57
Bremen 44
Ankara 34
Helsinki 32
Milan 30
Monmouth Junction 26
Hefei 25
Kecioeren 25
Brno 24
Toronto 24
Kocaeli 18
Nanjing 18
Munich 17
Woodbridge 17
Norwalk 15
Novara 15
Houston 14
Kunming 14
Brussels 13
Fairfield 13
Boardman 12
Nanchang 12
Formigine 11
Torino 11
Berlin 10
Jinan 10
Zanjan 10
Grafing 9
Leawood 9
Dong Ket 8
Montesarchio 8
Ardabil 7
Mülheim 7
Pavia 7
Seattle 7
Strasbourg 7
Turin 7
Udine 7
Varallo 7
Bologna 6
Calvisano 6
Chengdu 6
Dallas 6
Modena 6
Noicattaro 6
Savignano Sul Panaro 6
Cerano 5
Grignasco 5
Sacramento 5
Shenyang 5
Wuhan 5
Xian 5
Asti 4
Castiglione D'adda 4
Düsseldorf 4
Gunzenhausen 4
Legnano 4
San Giuliano Milanese 4
Trieste 4
Vercelli 4
Winnipeg 4
Zhengzhou 4
Albano Laziale 3
Amsterdam 3
Ashdod 3
Athens 3
Baotou 3
Bari 3
Borgomasino 3
Cambridge 3
Cassano Magnago 3
Changsha 3
Guangzhou 3
Hebei 3
Kaunas 3
Lyngby 3
Marano Di Napoli 3
Vienna 3
Augusta 2
Bangalore 2
Chaoyang 2
Gorla Maggiore 2
Hangzhou 2
Henderson 2
Irpin 2
Islamabad 2
Totale 4.399
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Nome #
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 141
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 121
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 114
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 108
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 104
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 97
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 97
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 97
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 96
Combretabenzodiazepines: a novel class of antitubulin agents 94
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 87
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 80
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 78
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 78
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 77
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 77
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 72
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 72
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 71
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 70
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 69
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 69
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 67
A concise entry into nonsymmetrical alkyl polyamines 66
Estrogenic analogues synthesized by click chemistry 66
New potential uroselective NO-donor alpha 1 antagonist 65
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 65
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 64
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 64
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 63
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 63
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 62
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 62
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 60
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 60
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 60
Chemoselective esterification of phenolic acids and alcohols 59
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 59
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 59
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 58
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 58
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 57
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 57
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 57
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 57
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 56
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 56
A Concise Entry into Nonsymmetrical Alkyl Polyamines 55
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 55
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 55
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 54
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 54
Sintesi e caratterizzazione di nuovi inibitori di DGKα 54
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 53
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 53
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 53
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 52
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 52
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 51
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 51
Synthesis and cytotoxic evaluation of combretafurazans 51
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 50
“Identification of the first selective Sirt3 inhibitor”, 50
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 50
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 50
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 50
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 50
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 49
Synthesis and biological activity of mustard derivatives of combretastatins 49
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 49
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 49
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 48
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 48
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 48
Identification of Novel Antitubulin Agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site 48
LC-MS CHARACTERIZATION OF IN VITRO METABOLISM OF COMBRETASTATIN A-4 47
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 47
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 47
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 47
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 46
Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones 46
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 45
The Nef reaction of isocyanides 45
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 45
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 45
Unnatural natural products from the transannular cyclization of lathyrane diterpenes 44
Sequential multicomponent synthesis of α-ketoimides, from acyl chlorides, isocyanides, and silver salts of carboxylic acids 44
Medicinal chemistry of combretastatin A4: present and future directions 43
Synthesis and biological evaluation of combretatriazoles 43
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 43
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 43
Medicinal Chemistry of Isocyanides 43
Ingenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines 42
Pietro Biginelli: The man behind the reaction 42
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 42
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 41
“Nicotinamide phosphoribosyltransferase (Nampt) inhibitors as anti-cancer agents in neuroblastoma” 41
An efficient synthesis of symmetric and unsymmetric bis-(ß-aminoamides) via Ugi multicomponent reaction. 41
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 41
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans 41
Totale 6.014
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Categoria #
all - tutte 37.605
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.605
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.479 0 0 121 8 241 227 303 74 148 178 165 14
2020/2021958 132 6 129 4 128 52 140 11 158 50 130 18
2021/2022927 48 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/202563 31 32 0 0 0 0 0 0 0 0 0 0
Totale 7.185