IRIS
TRON, Gian Cesare
 Distribuzione geografica
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Continente #
EU - Europa 4.253
NA - Nord America 3.840
AS - Asia 2.587
SA - Sud America 484
AF - Africa 62
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 2
Totale 11.237
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Nazione #
US - Stati Uniti d'America 3.738
IE - Irlanda 1.062
SG - Singapore 952
DE - Germania 675
IT - Italia 659
SE - Svezia 518
CN - Cina 491
HK - Hong Kong 471
UA - Ucraina 395
BR - Brasile 387
RU - Federazione Russa 279
FI - Finlandia 256
VN - Vietnam 220
IN - India 169
GB - Regno Unito 105
TR - Turchia 96
FR - Francia 84
CA - Canada 72
EE - Estonia 59
AR - Argentina 43
ID - Indonesia 30
KR - Corea 29
IR - Iran 27
PL - Polonia 27
CZ - Repubblica Ceca 26
BJ - Benin 25
BD - Bangladesh 24
BE - Belgio 21
AT - Austria 20
MX - Messico 20
ES - Italia 19
ZA - Sudafrica 19
JP - Giappone 16
EC - Ecuador 15
LT - Lituania 15
NL - Olanda 14
PK - Pakistan 12
EU - Europa 8
CO - Colombia 7
VE - Venezuela 7
AE - Emirati Arabi Uniti 6
CL - Cile 6
IQ - Iraq 6
PE - Perù 6
PY - Paraguay 6
AZ - Azerbaigian 5
MA - Marocco 5
TN - Tunisia 5
UY - Uruguay 5
KZ - Kazakistan 4
SA - Arabia Saudita 4
TH - Thailandia 4
DK - Danimarca 3
DO - Repubblica Dominicana 3
GR - Grecia 3
IL - Israele 3
JO - Giordania 3
KE - Kenya 3
PA - Panama 3
UZ - Uzbekistan 3
AU - Australia 2
BO - Bolivia 2
CH - Svizzera 2
DZ - Algeria 2
HN - Honduras 2
MD - Moldavia 2
NP - Nepal 2
OM - Oman 2
PH - Filippine 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
AL - Albania 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
CI - Costa d'Avorio 1
EG - Egitto 1
ET - Etiopia 1
HU - Ungheria 1
KG - Kirghizistan 1
KW - Kuwait 1
LB - Libano 1
LV - Lettonia 1
MY - Malesia 1
PT - Portogallo 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 11.237
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Città #
Dublin 1.062
Jacksonville 712
Hong Kong 470
Dearborn 373
Singapore 277
Beijing 244
Ashburn 207
Chandler 195
Wilmington 180
Piemonte 174
Ann Arbor 161
Lawrence 133
Princeton 133
Moscow 126
Munich 95
San Mateo 95
Los Angeles 92
Buffalo 75
Ho Chi Minh City 72
Andover 66
Novara 55
São Paulo 53
Helsinki 47
Hanoi 45
New York 45
Bremen 44
Ankara 43
Dallas 40
Redondo Beach 37
Milan 35
Santa Clara 33
Toronto 29
Frankfurt am Main 28
Seoul 28
Monmouth Junction 26
Turku 26
Cotonou 25
Hefei 25
Kecioeren 25
Brno 24
Houston 23
Montreal 23
Warsaw 20
London 19
Boston 18
Chennai 18
Kocaeli 18
Nanjing 18
Woodbridge 17
Atlanta 16
Brussels 16
Norwalk 16
Seattle 16
Stockholm 15
Tokyo 15
Brooklyn 14
Chicago 14
Kunming 14
Poplar 14
Fairfield 13
Johannesburg 13
Turin 13
Boardman 12
Nanchang 12
Rio de Janeiro 12
Denver 11
Formigine 11
Jinan 11
Nuremberg 11
Phoenix 11
Torino 11
Vienna 11
Berlin 10
Campinas 10
Tianjin 10
Zanjan 10
Brasília 9
Grafing 9
Leawood 9
Amsterdam 8
Bexley 8
Dong Ket 8
Montesarchio 8
Orem 8
Vercelli 8
Ardabil 7
Can Tho 7
Curitiba 7
Jakarta 7
Mülheim 7
Pavia 7
Porto Alegre 7
Secaucus 7
Strasbourg 7
Udine 7
Varallo 7
Belo Horizonte 6
Bologna 6
Calvisano 6
Chengdu 6
Totale 6.347
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Nome #
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 241
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 194
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 162
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 158
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 143
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 142
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 141
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 139
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 127
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 125
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 124
Combretabenzodiazepines: a novel class of antitubulin agents 120
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 115
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 114
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 113
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 113
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 112
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 111
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 109
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 106
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 105
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 102
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 100
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 100
Estrogenic analogues synthesized by click chemistry 99
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 99
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 98
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 96
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 95
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 95
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 94
A concise entry into nonsymmetrical alkyl polyamines 93
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 91
A Concise Entry into Nonsymmetrical Alkyl Polyamines 90
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 90
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 89
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 88
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 88
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 88
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 87
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 87
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 87
Medicinal Chemistry of Isocyanides 87
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 86
Chemoselective esterification of phenolic acids and alcohols 86
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 86
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 86
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 85
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 85
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 85
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 85
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 85
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 84
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 83
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 83
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 81
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 81
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 80
Sintesi e caratterizzazione di nuovi inibitori di DGKα 80
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 80
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 80
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 80
New potential uroselective NO-donor alpha 1 antagonist 79
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 79
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 78
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 78
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 77
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 77
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 77
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 75
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 74
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 73
The Nef reaction of isocyanides 73
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 73
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 72
An efficient synthesis of symmetric and unsymmetric bis-(ß-aminoamides) via Ugi multicomponent reaction. 72
Synthesis and biological evaluation of combretatriazoles 72
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 72
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 72
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 72
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 71
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 70
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions 70
“Synthesis and biological evaluation of triazole analogues of FK866, a potent inhibitor of human Nicotinamide Phosphoribosyltransferase” 69
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 69
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction 68
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 68
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 68
Synthesis and cytotoxic evaluation of combretafurazans 67
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 66
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 66
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 65
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 65
“Identification of the first selective Sirt3 inhibitor”, 65
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 64
Unnatural natural products from the transannular cyclization of lathyrane diterpenes 64
NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties 63
Synthesis and biological activity of mustard derivatives of combretastatins 63
Icilio Guareschi and his amazing “1897 reaction” 63
Identification of Novel Antitubulin Agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site 62
Totale 9.109
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Categoria #
all - tutte 63.101
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.101
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021559 0 0 0 0 0 52 140 11 158 50 130 18
2021/2022927 48 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/20251.939 31 32 109 27 53 205 190 162 402 183 159 386
2025/20262.412 270 190 455 863 585 49 0 0 0 0 0 0
Totale 11.473