IRIS
TRON, Gian Cesare
 Distribuzione geografica
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Continente #
EU - Europa 3.324
NA - Nord America 2.801
AS - Asia 620
Continente sconosciuto - Info sul continente non disponibili 8
SA - Sud America 3
Totale 6.756
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Nazione #
US - Stati Uniti d'America 2.769
IE - Irlanda 1.061
IT - Italia 563
SE - Svezia 502
DE - Germania 496
UA - Ucraina 371
CN - Cina 244
FI - Finlandia 198
IN - India 134
HK - Hong Kong 118
TR - Turchia 75
GB - Regno Unito 38
CA - Canada 31
FR - Francia 31
IR - Iran 27
BE - Belgio 14
CZ - Repubblica Ceca 14
RU - Federazione Russa 12
VN - Vietnam 9
EU - Europa 8
NL - Olanda 5
AT - Austria 4
BR - Brasile 3
DK - Danimarca 3
ES - Italia 3
GR - Grecia 3
IL - Israele 3
LT - Lituania 3
TH - Thailandia 3
PK - Pakistan 2
HN - Honduras 1
JP - Giappone 1
KR - Corea 1
MD - Moldavia 1
PH - Filippine 1
PL - Polonia 1
RO - Romania 1
SG - Singapore 1
SY - Repubblica araba siriana 1
Totale 6.756
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Città #
Dublin 1.061
Jacksonville 711
Dearborn 373
Chandler 195
Wilmington 180
Piemonte 174
Ann Arbor 161
Lawrence 133
Princeton 133
Hong Kong 118
Beijing 99
San Mateo 95
Andover 66
Ashburn 56
Bremen 44
Ankara 31
Milan 28
Monmouth Junction 26
Hefei 25
Kecioeren 25
Toronto 24
Helsinki 20
Kocaeli 18
Nanjing 18
Woodbridge 17
Norwalk 15
Houston 14
Kunming 14
Brno 13
Brussels 13
Fairfield 13
Novara 13
Nanchang 12
Formigine 11
Torino 11
Berlin 10
Jinan 10
Zanjan 10
Grafing 9
Leawood 9
Dong Ket 8
Montesarchio 8
Ardabil 7
Boardman 7
Mülheim 7
Pavia 7
Seattle 7
Strasbourg 7
Turin 7
Udine 7
Varallo 7
Bologna 6
Calvisano 6
Chengdu 6
Modena 6
Noicattaro 6
Savignano Sul Panaro 6
Cerano 5
Dallas 5
Grignasco 5
Sacramento 5
Shenyang 5
Wuhan 5
Xian 5
Asti 4
Castiglione D'adda 4
Düsseldorf 4
Gunzenhausen 4
Legnano 4
San Giuliano Milanese 4
Trieste 4
Vercelli 4
Winnipeg 4
Zhengzhou 4
Albano Laziale 3
Ashdod 3
Athens 3
Baotou 3
Borgomasino 3
Cambridge 3
Cassano Magnago 3
Changsha 3
Guangzhou 3
Hebei 3
Kaunas 3
Lyngby 3
Marano Di Napoli 3
Vienna 3
Augusta 2
Bangalore 2
Bari 2
Chaoyang 2
Gorla Maggiore 2
Hangzhou 2
Henderson 2
Islamabad 2
Nanning 2
Napoli 2
Novokuznetsk 2
Omegna 2
Totale 4.264
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Nome #
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 137
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 116
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 111
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 105
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 103
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 97
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 94
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 94
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 94
Combretabenzodiazepines: a novel class of antitubulin agents 93
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 86
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 79
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 76
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 76
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 75
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 74
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 70
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 69
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 69
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 68
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 67
New potential uroselective NO-donor alpha 1 antagonist 65
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 65
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 64
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 64
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 63
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 63
Estrogenic analogues synthesized by click chemistry 62
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 62
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 61
A concise entry into nonsymmetrical alkyl polyamines 61
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 61
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 61
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 59
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 59
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 58
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 58
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 57
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 57
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 56
Chemoselective esterification of phenolic acids and alcohols 56
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 56
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 56
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 56
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 55
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 55
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 54
Sintesi e caratterizzazione di nuovi inibitori di DGKα 54
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 54
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 54
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 53
A Concise Entry into Nonsymmetrical Alkyl Polyamines 52
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 52
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 52
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 52
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 52
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 51
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 51
Synthesis and cytotoxic evaluation of combretafurazans 50
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 50
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 49
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 49
“Identification of the first selective Sirt3 inhibitor”, 49
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 49
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 49
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 49
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 48
Synthesis and biological activity of mustard derivatives of combretastatins 48
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 48
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 47
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 47
Identification of Novel Antitubulin Agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site 47
LC-MS CHARACTERIZATION OF IN VITRO METABOLISM OF COMBRETASTATIN A-4 46
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 46
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 46
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 46
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 46
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 46
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 45
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 45
The Nef reaction of isocyanides 45
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 45
Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones 45
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 44
Sequential multicomponent synthesis of α-ketoimides, from acyl chlorides, isocyanides, and silver salts of carboxylic acids 43
Medicinal chemistry of combretastatin A4: present and future directions 42
Synthesis and biological evaluation of combretatriazoles 42
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 42
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 42
Ingenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines 41
Unnatural natural products from the transannular cyclization of lathyrane diterpenes 41
Pietro Biginelli: The man behind the reaction 41
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 41
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 40
“Nicotinamide phosphoribosyltransferase (Nampt) inhibitors as anti-cancer agents in neuroblastoma” 40
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 40
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 40
Medicinal Chemistry of Isocyanides 40
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 39
IN VITRO METABOLIC FATE OF COMBRETASTATIN A-4: EVIDENCE FOR THE FORMATION OF QUINONE METABOLITES 39
Totale 5.851
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Categoria #
all - tutte 32.114
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.114
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201926 0 0 0 0 0 0 0 0 0 0 19 7
2019/20201.492 3 10 121 8 241 227 303 74 148 178 165 14
2020/2021958 132 6 129 4 128 52 140 11 158 50 130 18
2021/2022927 48 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024456 46 43 74 20 117 7 121 14 4 1 9 0
Totale 6.970