IRIS
TRON, Gian Cesare
 Distribuzione geografica
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Continente #
EU - Europa 5.553
NA - Nord America 4.767
AS - Asia 3.479
SA - Sud America 553
AF - Africa 83
Continente sconosciuto - Info sul continente non disponibili 10
OC - Oceania 3
Totale 14.448
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Nazione #
US - Stati Uniti d'America 4.627
RU - Federazione Russa 1.335
SG - Singapore 1.168
IE - Irlanda 1.064
CN - Cina 808
DE - Germania 696
IT - Italia 689
SE - Svezia 519
HK - Hong Kong 481
VN - Vietnam 447
BR - Brasile 420
UA - Ucraina 395
FI - Finlandia 256
FR - Francia 228
IN - India 198
GB - Regno Unito 126
TR - Turchia 99
CA - Canada 89
EE - Estonia 59
AR - Argentina 51
BD - Bangladesh 42
ID - Indonesia 33
KR - Corea 32
MX - Messico 31
PL - Polonia 30
IR - Iran 28
CZ - Repubblica Ceca 26
ES - Italia 26
BJ - Benin 25
BE - Belgio 23
JP - Giappone 23
AT - Austria 22
IQ - Iraq 22
EC - Ecuador 21
ZA - Sudafrica 21
NL - Olanda 20
PK - Pakistan 19
LT - Lituania 16
CL - Cile 15
VE - Venezuela 14
CO - Colombia 10
TH - Thailandia 9
AE - Emirati Arabi Uniti 8
EU - Europa 8
MA - Marocco 8
UZ - Uzbekistan 8
PE - Perù 7
PH - Filippine 7
SA - Arabia Saudita 7
TN - Tunisia 7
AZ - Azerbaigian 6
DZ - Algeria 6
JO - Giordania 6
KE - Kenya 6
PY - Paraguay 6
IL - Israele 5
UY - Uruguay 5
BO - Bolivia 4
DK - Danimarca 4
GR - Grecia 4
HN - Honduras 4
KZ - Kazakistan 4
AU - Australia 3
DO - Repubblica Dominicana 3
EG - Egitto 3
JM - Giamaica 3
LB - Libano 3
MD - Moldavia 3
NP - Nepal 3
OM - Oman 3
PA - Panama 3
TT - Trinidad e Tobago 3
CH - Svizzera 2
GA - Gabon 2
KG - Kirghizistan 2
NI - Nicaragua 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AL - Albania 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BW - Botswana 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
ET - Etiopia 1
GE - Georgia 1
HU - Ungheria 1
KW - Kuwait 1
KY - Cayman, isole 1
LV - Lettonia 1
MM - Myanmar 1
MY - Malesia 1
PT - Portogallo 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
ZM - Zambia 1
Totale 14.448
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Città #
Dublin 1.064
Jacksonville 714
Hong Kong 479
San Jose 466
Singapore 387
Dearborn 373
Ashburn 270
Beijing 255
Chandler 195
Moscow 182
Wilmington 181
Piemonte 174
Ann Arbor 161
Lawrence 133
Princeton 133
Ho Chi Minh City 132
Lauterbourg 131
Los Angeles 110
Hanoi 104
Munich 95
San Mateo 95
Council Bluffs 92
Buffalo 75
New York 72
Andover 66
São Paulo 56
Novara 55
Santa Clara 54
Helsinki 47
Dallas 46
Bremen 44
Ankara 43
Frankfurt am Main 38
Milan 38
Redondo Beach 37
Toronto 35
Orem 29
Chennai 28
Montreal 28
Seoul 28
Hefei 26
Monmouth Junction 26
Turku 26
Cotonou 25
Houston 25
Kecioeren 25
Brno 24
Warsaw 22
London 21
Atlanta 19
Boston 19
Chicago 19
Da Nang 19
Haiphong 19
Nanjing 19
Tianjin 19
Tokyo 19
Kocaeli 18
Brooklyn 17
Brussels 17
Seattle 17
Woodbridge 17
Denver 16
Guangzhou 16
Norwalk 16
Phoenix 16
Poplar 16
Stockholm 16
Hangzhou 15
Johannesburg 15
Columbus 14
Kunming 14
Rio de Janeiro 14
Fairfield 13
Jinan 13
Nuremberg 13
Turin 13
Boardman 12
Nanchang 12
The Dalles 12
Formigine 11
Torino 11
Vienna 11
Berlin 10
Brasília 10
Campinas 10
Can Tho 10
Hillsboro 10
Mexico City 10
Shenzhen 10
Zanjan 10
Amsterdam 9
Bexley 9
Biên Hòa 9
Falkenstein 9
Grafing 9
Leawood 9
Mumbai 9
Baghdad 8
Dong Ket 8
Totale 7.651
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Nome #
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 276
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 238
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 192
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 189
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 178
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 172
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 166
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 165
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 159
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 158
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 155
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 138
Combretabenzodiazepines: a novel class of antitubulin agents 138
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 137
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 135
Estrogenic analogues synthesized by click chemistry 133
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 133
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 131
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 130
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 130
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 130
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 130
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 130
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 128
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 127
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 127
Medicinal Chemistry of Isocyanides 127
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 123
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 121
A concise entry into nonsymmetrical alkyl polyamines 120
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 120
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 120
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 119
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 118
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 116
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 115
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 115
A Concise Entry into Nonsymmetrical Alkyl Polyamines 113
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 113
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 113
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 113
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 110
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 109
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 109
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 108
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 108
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 108
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 107
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 106
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 106
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 106
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 106
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 105
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 104
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 104
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 104
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 103
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 102
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 102
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 102
Chemoselective esterification of phenolic acids and alcohols 101
Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcus aureus 100
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 100
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction 99
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 99
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 99
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 99
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs? 98
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 98
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 97
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 96
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 95
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 94
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 94
An efficient synthesis of symmetric and unsymmetric bis-(ß-aminoamides) via Ugi multicomponent reaction. 93
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 93
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 93
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 92
Sintesi e caratterizzazione di nuovi inibitori di DGKα 92
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 92
Icilio Guareschi and his amazing “1897 reaction” 92
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 91
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 90
Synthesis and biological evaluation of combretatriazoles 90
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 89
New potential uroselective NO-donor alpha 1 antagonist 88
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions 88
The Nef reaction of isocyanides 87
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 86
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 85
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 85
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 85
NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties 84
Exploiting the Different Nucleophilicity of the Isocyano Group: A Strategy for the Isocyanide Functionalization 83
“Synthesis and biological evaluation of triazole analogues of FK866, a potent inhibitor of human Nicotinamide Phosphoribosyltransferase” 83
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans 83
Pietro Biginelli: The man behind the reaction 82
Synthesis and cytotoxic evaluation of combretafurazans 80
“Identification of the first selective Sirt3 inhibitor”, 80
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives 80
Totale 11.435
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Categoria #
all - tutte 71.921
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 71.921
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202118 0 0 0 0 0 0 0 0 0 0 0 18
2021/2022927 48 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/20251.939 31 32 109 27 53 205 190 162 402 183 159 386
2025/20265.623 270 190 455 863 585 361 735 940 329 510 294 91
Totale 14.684