IRIS
TRON, Gian Cesare
 Distribuzione geografica
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Continente #
EU - Europa 3.442
NA - Nord America 2.887
AS - Asia 858
Continente sconosciuto - Info sul continente non disponibili 8
SA - Sud America 4
Totale 7.199
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Nazione #
US - Stati Uniti d'America 2.849
IE - Irlanda 1.061
IT - Italia 588
DE - Germania 523
SE - Svezia 504
UA - Ucraina 373
CN - Cina 244
FI - Finlandia 219
SG - Singapore 210
IN - India 134
HK - Hong Kong 132
TR - Turchia 83
GB - Regno Unito 47
CA - Canada 35
FR - Francia 32
IR - Iran 27
CZ - Repubblica Ceca 26
BE - Belgio 19
RU - Federazione Russa 13
VN - Vietnam 9
EU - Europa 8
NL - Olanda 8
LT - Lituania 6
AT - Austria 5
TH - Thailandia 4
BR - Brasile 3
DK - Danimarca 3
ES - Italia 3
GR - Grecia 3
IL - Israele 3
AZ - Azerbaigian 2
EE - Estonia 2
PA - Panama 2
PH - Filippine 2
PK - Pakistan 2
AE - Emirati Arabi Uniti 1
BG - Bulgaria 1
EC - Ecuador 1
HN - Honduras 1
HU - Ungheria 1
JO - Giordania 1
JP - Giappone 1
KR - Corea 1
KZ - Kazakistan 1
LV - Lettonia 1
MD - Moldavia 1
PL - Polonia 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
SY - Repubblica araba siriana 1
Totale 7.199
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Città #
Dublin 1.061
Jacksonville 711
Dearborn 373
Chandler 195
Wilmington 180
Piemonte 174
Ann Arbor 161
Singapore 147
Lawrence 133
Princeton 133
Hong Kong 131
Beijing 99
San Mateo 95
Andover 66
Ashburn 57
Bremen 44
Helsinki 36
Ankara 35
Milan 32
Monmouth Junction 26
Toronto 26
Hefei 25
Kecioeren 25
Brno 24
Munich 20
Novara 20
Kocaeli 18
Nanjing 18
Santa Clara 18
Woodbridge 17
Brussels 16
Norwalk 15
Houston 14
Kunming 14
Fairfield 13
Boardman 12
Nanchang 12
Formigine 11
Torino 11
Berlin 10
Jinan 10
Zanjan 10
Grafing 9
Leawood 9
Turin 9
Dong Ket 8
Montesarchio 8
Ardabil 7
Mülheim 7
Pavia 7
Seattle 7
Strasbourg 7
Udine 7
Varallo 7
Bologna 6
Calvisano 6
Chengdu 6
Dallas 6
London 6
Modena 6
Noicattaro 6
Savignano Sul Panaro 6
Cerano 5
Espoo 5
Frankfurt am Main 5
Grignasco 5
Sacramento 5
Shenyang 5
Vercelli 5
Wuhan 5
Xian 5
Asti 4
Castiglione D'adda 4
Düsseldorf 4
Gunzenhausen 4
Legnano 4
San Giuliano Milanese 4
Trieste 4
Vienna 4
Winnipeg 4
Zhengzhou 4
Albano Laziale 3
Amsterdam 3
Ashdod 3
Athens 3
Baotou 3
Bari 3
Borgomasino 3
Cambridge 3
Cassano Magnago 3
Changsha 3
Guangzhou 3
Hebei 3
Kaunas 3
Los Angeles 3
Lyngby 3
Marano Di Napoli 3
Augusta 2
Baku 2
Bangalore 2
Totale 4.527
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Nome #
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors 148
Identification of a novel DGKa inhibitor for XLP-1 therapy by virtual screening 123
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement 115
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group 112
Inhibitors of Nicotinamide Phosphoribosyltransferase, compositions, products and uses thereof. 106
Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents 101
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity 98
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury 98
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells 98
Combretabenzodiazepines: a novel class of antitubulin agents 96
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 88
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 82
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. 81
NOVEL DIACYLGLYCEROL KINASE ALPHA INHIBITORS FOR X-LINKED LYMPHOPROLIFERATIVE DISEASE 1 THERAPY 80
Sviluppo di inibitori di DGKα per la terapia della psoriasi all'interno del progetto "Terapie innovative per la psoriasi (TIPSO)" 79
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors 79
Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups? 76
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 74
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 72
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 72
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry 71
A concise entry into nonsymmetrical alkyl polyamines 71
SYNTHESIS AND CHARACTERIZATION OF NEW DGKα INHIBITORS 71
Estrogenic analogues synthesized by click chemistry 68
Bisnorsesquiterpenoids from Euphorbia resinifera berg. and an expeditious procedure to obtain resiniferatoxin from its fresh latex 67
New potential uroselective NO-donor alpha 1 antagonist 66
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 66
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 66
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors: novel modulators of antitumor immunity 66
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis 65
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2 64
Solution-Phase Parallel Synthesis of Aryloxyimino Amides via a Novel Multicomponent Reaction among Aromatic (Z)‑Chlorooximes, Isocyanides, and Electron-Deficient Phenols 64
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island 64
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement 62
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage 61
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 61
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 60
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase 60
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus 60
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 60
Chemoselective esterification of phenolic acids and alcohols 59
“Characterization of nicotinamide phosphoribosyltransferase inhibitors as anticancer agents” 59
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids 59
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 59
A Concise Entry into Nonsymmetrical Alkyl Polyamines 58
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors are novel modulators of myeloid-derived suppressor cells 58
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 57
Are the 1,4 and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups? 57
An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris 57
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines 57
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors 57
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 56
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides 56
Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles 56
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 55
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 55
Sintesi e caratterizzazione di nuovi inibitori di DGKα 55
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 55
ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles 53
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications 52
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 52
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles 52
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy 52
Synthesis and cytotoxic evaluation of combretafurazans 51
Synthesis and biological activity of mustard derivatives of combretastatins 51
“Discovery of a nanomolar inhibitor of NMPRTase by Click Chemistry” 51
“Identification of the first selective Sirt3 inhibitor”, 51
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization 51
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 51
Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists? 51
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 50
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells 50
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide 50
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 50
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 49
Identification of Novel Antitubulin Agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site 49
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 49
In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes 48
“Nicotinamide phosphoribosyl transferase (Nampt) inhibitors as antitumoral agents” 48
“Synthesis and in vitro evaluation of tetrasubstituted pyridines as potential PI3Ks inhibitors” 48
LC-MS CHARACTERIZATION OF IN VITRO METABOLISM OF COMBRETASTATIN A-4 47
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 47
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 46
The Nef reaction of isocyanides 46
Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones 46
Synthesis and biological evaluation of combretatriazoles 45
N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines 45
Medicinal chemistry of combretastatin A4: present and future directions 44
Unnatural natural products from the transannular cyclization of lathyrane diterpenes 44
ZINClick: a database of 16 million of new and patentable 1,4 disubstituted triazoles easily synthetizable 44
Sequential multicomponent synthesis of α-ketoimides, from acyl chlorides, isocyanides, and silver salts of carboxylic acids 44
Medicinal Chemistry of Isocyanides 44
Pietro Biginelli: The man behind the reaction 43
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 43
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 42
Ingenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines 42
“Nicotinamide phosphoribosyltransferase (Nampt) inhibitors as anti-cancer agents in neuroblastoma” 42
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 42
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N- substituted α-amino acid amides 42
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans 42
Totale 6.185
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Categoria #
all - tutte 43.432
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.432
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.109 0 0 0 0 0 227 303 74 148 178 165 14
2020/2021958 132 6 129 4 128 52 140 11 158 50 130 18
2021/2022927 48 24 109 108 37 4 93 20 58 57 131 238
2022/20232.140 151 95 112 31 118 186 73 138 1.092 24 61 59
2023/2024608 46 43 74 20 117 7 121 14 4 1 42 119
2024/2025293 31 32 109 27 53 41 0 0 0 0 0 0
Totale 7.415