Vanillin is widely used as a flavoring agent in foods, perfumes and in several other applications. Even if huge amounts of vanillin are annually employed in these manufacturing processes, its reactivity is underexplored, especially for the formation of potentially toxic substances. In this context, we observed the formation of orange to red crystalline compounds in the reaction of vanillin with secondary amines in aerobic conditions. NMR and HRMS allowed identifying the products as 2,5-diamino-1,4-benzoquinones. Preliminary investigations of this reaction led to a proposed mechanism involving an oxidative fragmentation of vanillin as the key step. MTT tests did not show any toxic effect up to 0.1 mM.
Unprecedented Formation of 2,5-Diaminoquinones from the Reaction of Vanillin with Secondary Amines in Aerobic Conditions
Barbero, Mauro;Papillo, Valentina A.;Grolla, Ambra A.;Negri, Roberto;Travaglia, Fabiano;Bordiga, Matteo;Condorelli, Fabrizio;Arlorio, Marco
;Giovenzana, Giovanni B.
2020-01-01
Abstract
Vanillin is widely used as a flavoring agent in foods, perfumes and in several other applications. Even if huge amounts of vanillin are annually employed in these manufacturing processes, its reactivity is underexplored, especially for the formation of potentially toxic substances. In this context, we observed the formation of orange to red crystalline compounds in the reaction of vanillin with secondary amines in aerobic conditions. NMR and HRMS allowed identifying the products as 2,5-diamino-1,4-benzoquinones. Preliminary investigations of this reaction led to a proposed mechanism involving an oxidative fragmentation of vanillin as the key step. MTT tests did not show any toxic effect up to 0.1 mM.File | Dimensione | Formato | |
---|---|---|---|
Eur J Org Chem - 2019 - Barbero - Unprecedented Formation of 2 5‐Diaminoquinones from the Reaction of Vanillin with.pdf
file disponibile solo agli amministratori
Licenza:
Copyright dell'editore
Dimensione
457.9 kB
Formato
Adobe PDF
|
457.9 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.