An unexpected nitro group displacement during a nitro-Mannich reaction led to the one-pot formation of the octahydro-2Hpyrazino[1,2-a]pyrazine core, representing the shortest access to date to this pharmacologically relevant heterobicyclic system. A mechanistic hypothesis is suggested and supported by specific experiments and HRMS analysis of reaction mixtures.
A serendipitous one-pot synthesis of the octahydro-2H-pyrazino[1,2-a]pyrazine core
Minazzi, Paolo;Giovenzana, Giovanni Battista;Travagin, Fabio
2024-01-01
Abstract
An unexpected nitro group displacement during a nitro-Mannich reaction led to the one-pot formation of the octahydro-2Hpyrazino[1,2-a]pyrazine core, representing the shortest access to date to this pharmacologically relevant heterobicyclic system. A mechanistic hypothesis is suggested and supported by specific experiments and HRMS analysis of reaction mixtures.File in questo prodotto:
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