Thermodynamic and kinetic measurements show an apparent paradox. The stability of complexes of lanthanide trivalent ions is higher with the heptadentate ligand OBETA (ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid) than with its octadentate homologue EGTA (2,2′-oxybis(ethylamine)-N,N,N′,N′-tetraacetic acid). The unusual properties of Gd(OBETA)− (see structure), combined with the presence of two fast exchanging coordinated water molecules, candidates this complex as an MRI contrast agent.
Lower Ligand Denticity Leading to Improved Thermodynamic and Kinetic Stability of the Gd3+ Complex: The Strange Case of OBETA
BOTTA, Mauro;FEKETE, Marianna;GIOVENZANA, Giovanni Battista;NEGRI, Roberto;TEI, LORENZO;
2012-01-01
Abstract
Thermodynamic and kinetic measurements show an apparent paradox. The stability of complexes of lanthanide trivalent ions is higher with the heptadentate ligand OBETA (ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid) than with its octadentate homologue EGTA (2,2′-oxybis(ethylamine)-N,N,N′,N′-tetraacetic acid). The unusual properties of Gd(OBETA)− (see structure), combined with the presence of two fast exchanging coordinated water molecules, candidates this complex as an MRI contrast agent.File in questo prodotto:
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