Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.
Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes
D'Alfonso, Sandra;Stracuzzi, Marta;Raviolo, Silvia;Rizzollo, Stefano;Gigliotti, Luca;Boggio, Elena;Bellomo, Giorgio;Basagni, Chiara;Bona, Gianni;Rabbone, Ivana;Dianzani, Umberto;Prodam, Flavia
2020-01-01
Abstract
Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.File in questo prodotto:
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