This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup H, which we previously found to be independently associated with a lower hazard of radiation-induced fibrosis.
DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-induced Skin Fibrosis after Treatment of Breast Cancer: a Multifactorial Genetic Approach
TERRAZZINO, SALVATORE;DEANTONIO, LETIZIA;CARGNIN, Sarah;CANONICO, Pier Luigi;GENAZZANI, Armando;KRENGLI, Marco
2017-01-01
Abstract
This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup H, which we previously found to be independently associated with a lower hazard of radiation-induced fibrosis.File in questo prodotto:
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