The European Hematology Association Roadmap for European Hematology Research: a consensus document.

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Haematologica Volume 101, Issue 2, 1 February 2016, Pages 115-208 Open Access The european hematology association roadmap for european hematology research: A consensus document (Article) Engert, A.a , Balduini, C.b, Brand, A.c, Coiffier, B.d, Cordonnier, C.e, Döhner, H.f, De Wit, T.D.g, Eichinger, S.h, Fibbe, W.c, Green, T.i, De Haas, F.g, Iolascon, A.j, Jaffredo, T.k, Rodeghiero, F.l, Sall Es, G.m, Schuringa, J.J.n, André, M.o, Andre-Schmutz, I.p, Bacigalupo, A.q, Bochud, P.-Y.r, Den Boer, M.s, Bonini, C.t, Camaschella, C.u, Cant, A.v, Cappellini, M.D.w, Cazzola, M.x, Celso, C.L.y, Dimopoulos, M.z, Douay, L.aa, Dzierzak, E.ab, Einsele, H.ac, Ferreri, A.ad, De Franceschi, L.ae, Gaulard, P.af, Gottgens, B.ag, Greinacher, A.ahai, Gresele, P.aj, Gribben, J.ak, De Haan, G.al, Hansen, J.-B.am, Hochhaus, A.an, Kadir, R.ao, Kaveri, S.ap, Kouskoff, V.aq, Kühne, T.ar, Kyrle, P.as, Ljungman, P.at, Maschmeyer, G.au, Méndez-Ferrer, S.ag, Milsom, M.av, Mummery, C.aw, Ossenkoppele, G.ax, Pecci, A.x, Peyvandi, F.w, Philipsen, S.s, Reitsma, P.aw, Ribera, J.M.ay, Risitano, A.az, Rivella, S.ba, Ruf, W.bb, Schroeder, T.bc, Scully, M.bd, Socie, G.be, Staal, F.aw, Stanworth, S.bf, Stauder, R.bg, Stilgenbauer, S.bh, Tamary, H.bi, Theilgaard-Mönch, K.bj, Thein, S.L.bk, Tilly, H.bl, Trneny, M.bm, Vainchenker, W.bn, Vannucchi, A.M.bo, Viscoli, C.bp, Vrielink, H.bq, Zaaijer, H.bq, Zanella, A.br, Zolla, L.bs, Zwaginga, J.J.aw, Martinez, P.A.bt, Van Den Akker, E.bq, Allard, S.bu, Anagnou, N.bv, Andolfo, I.az, Andrau, J.-C.bw, Angelucci, E.bx, Anstee, D.by, Aurer, I.bz, Avet-Loiseau, H.ca, Aydinok, Y.cb, Bakchoul, T.ah, Balduini, A.b, Barcellini, W.br, Baruch, D.p, Baruchel, A.cc, Bayry, J.ap, Bento, C.cd, Van Den Berg, A.al, Bernardi, R.ad, Bianchi, P.br, Bigas, A.ce, Biondi, A.cf, Bohonek, M.cg, Bonnet, D.ch, Borchmann, P.ci, Borregaard, N.bj, Brækkan, S.am, Van Den Brink, M.cj, Brodin, E.ck, Bullinger, L.cl, Buske, C.bh, Butzeck, B.cm, Cammenga, J.cn, Campo, E.co, Carbone, A.cp, Cervantes, F.co, Cesaro, S.cq, Charbord, P.aa, Claas, F.aw, Cohen, H.cr, Conard, J.cs, Coppo, P.ct, Vives Corron, J.-L.co, Da Costa, L.cu, Davi, F.aa, Delwel, R.s, Dianzani, I.cv, Domanović, D.cw, Donnelly, P.cx, Drnovšek, T.D.cy, Dreyling, M.cz, Du, M.-Q.ag, Dufour, C.da, Durand, C.aa, Efremov, D.db, Eleftheriou, A.dc, Elion, J.dd, Emonts, M.v, Engelhardt, M.de, Ezine, S.p, Falkenburg, F.aw, Favier, R.df, Federico, M.dg, Fenaux, P.be, Fitzgibbon, J.dh, Flygare, J.di, Foà, R.dj, Forrester, L.ab, Galacteros, F.dk, Garagiola, I.w, Gardiner, C.dl, Garraud, O.dm, Van Geet, C.dn, Geiger, H.bh, Geissler, J.do, Germing, U.dp, Ghevaert, C.ag, Girelli, D.ae, Godeau, B.dk, Gökbuget, N.dq, Goldschmidt, H.dr, Goodeve, A.ds, Graf, T.dt, Graziadei, G.w, Griesshammer, M.du, Gruel, Y.dv, Guilhot, F.dw, Von Gunten, S.dx, Gyssens, I.dy, Halter, J.dz, Harrison, C.ea, Harteveld, C.aw, Hellström-Lindberg, E.at, Hermine, O.p, Higgs, D.dl, Hillmen, P.eb, Hirsch, H.ec, Hoskin, P.ed, Huls, G.al, Inati, A.ee, Johnson, P.ef, Kattamis, A.eg, Kiefel, V.eh, Kleanthous, M.ei, Klump, H.ej, Krause, D.ek, Hovinga, J.K.dx, Lacaud, G.aq, Lacroix-Desmazes, S.ap, Landman-Parker, J.el, Legouill, S.em, Lenz, G.en, Von Lilienfeld-Toal, M.an, Von Lindern, M.bq, Lopez-Guillermo, A.eo, Lopriore, E.ep, Lozano, M.co, Macintyre, E.p, Makris, M.dreq, Mannhalter, C.as, Martens, J.er, Mathas, S.es, Matzdorff, A.et, Medvinsky, A.ab, Menendez, P.co, Migliaccio, A.R.eu, Miharada, K.di, Mikulska, M.bp, Minard, V.bn, Montalbán, C.ev, De Montalembert, M.ew, Montserrat, E.eo, Morange, P.-E.ex, Mountford, J.ey, Muckenthaler, M.dr, Müller-Tidow, C.ez, Mumford, A.fa, Nadel, B.fb, Navarro, J.-T.ay, El Nemer, W.fc, Noizat-Pirenne, F.fd, O’Mahony, B.fe, Oldenburg, J.ff, Olsson, M.fg, Oostendorp, R.fh, Palumbo, A.fi, Passamonti, F.fj, Patient, R.dl, De Latour, R.P.fk, Pflumio, F.fl, Pierelli, L.dj, Piga, A.cv, Pollard, D.ao, Raaijmakers, M.s, Radford, J.aq, Rambach, R.fm, Koneti Rao, A.fn, Raslova, H.fo, Rebulla, P.fp, Rees, D.fq, Ribrag, V.bn, Rijneveld, A.s, Rinalducci, S.bs, Robak, T.fr, Roberts, I.dl, Rodrigues, C.v, Rosendaal, F.aw, Rosenwald, A.fs, Rule, S.ft, Russo, R.az, Saglio, G.cv, Sanchez, M.fu, Scharf, R.E.fv, Schlenke, P.fw, Semple, J.fx, Sierra, J.fy, So-Osman, C.bq, Soria, J.M.fz, Stamatopoulos, K.ga, Stegmayr, B.gb, Stunnenberg, H.cx, Swinkels, D.cx, Barata, J.P.T.gc, Taghon, T.gd, Taher, A.ge, Terpos, E.z, Thachil, J.gf, Tissot, J.D.gg, Touw, I.s, Toye, A.gh, Trappe, R.gi, Traverse-Glehen, A.gj, Unal, S.gk, Vaulont, S.gl, Viprakasit, V.gm, Vitolo, U.fi, Van Wijk, R.gn, Wójtowicz, A.go, Zeerleder, S.bq, Zieger, B.de, EHA Roadmap for European Hematology Researchgp View additional authors a Universität zu Köln, Cologne, Germany b IRCCS Policlinico San Matteo Foundation, Pavia, Italy c Leids Universitair Medisch Centrum, Leiden, Netherlands View additional affiliations View references (372) Abstract The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.