We describe herein a novel Pt(IV)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(IV) complex containing a N-donor ligand coordinated during the Pt(II) → Pt(IV) oxidation step. Remarkably, the Pt(IV)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(IV) antitumor prodrugs.
Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(IV)-acetamidato complex
RAVERA, Mauro;GABANO, Elisabetta;FREGONESE, FEDERICO;OSELLA, Domenico
2015-01-01
Abstract
We describe herein a novel Pt(IV)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(IV) complex containing a N-donor ligand coordinated during the Pt(II) → Pt(IV) oxidation step. Remarkably, the Pt(IV)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(IV) antitumor prodrugs.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
