Cytotoxicity in the mu M range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.
N,N,N',N'-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line
CALDARELLI, ANTONIO;DE BIASIO, VALERIA;GIOVENZANA, Giovanni Battista;NEGRI, Roberto
2014-01-01
Abstract
Cytotoxicity in the mu M range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.File in questo prodotto:
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