Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin–lattice relaxivity of the Gd-loaded-PAP–liposomes as compared to Gd–DTPA–BSA equivalents. The potential application of contrast syndecan-1– and Rituximab–liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.
Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)
BOTTA, Mauro;
2014-01-01
Abstract
Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin–lattice relaxivity of the Gd-loaded-PAP–liposomes as compared to Gd–DTPA–BSA equivalents. The potential application of contrast syndecan-1– and Rituximab–liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.File in questo prodotto:
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