Amino-bisphosphonates (N-BPs)haveawiderangeofclinicalapplicationstotreatbonediseases.Their Amino-bisphosphonates (N-BPs)haveawiderangeofclinicalapplicationstotreatbonediseases.Their activity loweredfarnesylpyrophosphate(FPP)endogenouslevelsbyinhibitingFPPsynthase.Inepithelial cells ithasbeendemonstratedthatFPPreducesbothcellproliferationandmigrationactivting glucocorticoid receptor.InthisstudytwoN-BPs(zoledronateandneridronate)usedatlowconcentra- tions (100nMto10 μM) areabletostimulatehumankeratinocytesproliferationreducingglucocorticoid receptoractivation.
Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor.
RENO', Filippo;RIZZI, Manuela;INVERNIZZI, MARCO;MIGLIARIO, MARIO;CISARI, Carlo
2013-01-01
Abstract
Amino-bisphosphonates (N-BPs)haveawiderangeofclinicalapplicationstotreatbonediseases.Their Amino-bisphosphonates (N-BPs)haveawiderangeofclinicalapplicationstotreatbonediseases.Their activity loweredfarnesylpyrophosphate(FPP)endogenouslevelsbyinhibitingFPPsynthase.Inepithelial cells ithasbeendemonstratedthatFPPreducesbothcellproliferationandmigrationactivting glucocorticoid receptor.InthisstudytwoN-BPs(zoledronateandneridronate)usedatlowconcentra- tions (100nMto10 μM) areabletostimulatehumankeratinocytesproliferationreducingglucocorticoid receptoractivation.File in questo prodotto:
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2013 NBP kerat eur j pharm.pdf
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