Nanocapsules of polybutylcyanoacrylate containing doxorubicine were prepared from w/o microemulsion. A concentration of about 10 % of the drug was obtained. After washing, dispersion and lyophilization of the nanocapsules, some experiments were performed in vivo and in vitro. About 1 % of doxorubicine was released in vitro in 48 hours; after injection on the hairless back of rabbits, the nanoparticles without the drug gave any inflammatory processes, while the nanocapsules containing doxorubicine gave a deeper and more prolonged ulcer than that of the same amount of doxorubicine in solution, indicating that practically all the drug was inside the nanocapsules.
Doxorubicine englobed in polybutylcyanoacrylate nanocapsules: behaviour in vitro and in vivo
MOREL, Silvia;VIANO, Ilario
1991-01-01
Abstract
Nanocapsules of polybutylcyanoacrylate containing doxorubicine were prepared from w/o microemulsion. A concentration of about 10 % of the drug was obtained. After washing, dispersion and lyophilization of the nanocapsules, some experiments were performed in vivo and in vitro. About 1 % of doxorubicine was released in vitro in 48 hours; after injection on the hairless back of rabbits, the nanoparticles without the drug gave any inflammatory processes, while the nanocapsules containing doxorubicine gave a deeper and more prolonged ulcer than that of the same amount of doxorubicine in solution, indicating that practically all the drug was inside the nanocapsules.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
