Scaffolds in bone tissue engineering (BTE) function as temporary 3D support for cells, recreating a bone-like microenvironment that promotes their adhesion, proliferation, and differentiation. Calcium phosphate (CaP) ceramics are widely used in orthopedics owing to their similarity to biological apatite, while ion doping and bioactive glass addition further enhance biological activity and mechanical stability. Here, composite scaffolds were fabricated from Sr,Mg-doped CaP combined with pristine or Sr,Mg-doped mesoporous bioactive glass nanoparticles (MBGNs). MBGNs incorporation promoted α -tricalcium phosphate phase formation and significantly improved the compressive strength via reduced microporosity through liquid-phase sintering without compromising the macroporosity. Bioactivity was confirmed under dynamic perfusion. Obtained scaffolds supported attachment and growth of human bone marrow stromal cells and endothelial cells, with enhanced pro-angiogenic properties. These results highlight Sr,Mg-doped CaP/MBGN composites as a mechanically reinforced, osteogenic and pro-angiogenic platform for BTE.
Composite scaffolds based on mesoporous bioactive glasses and Sr,Mg-doped calcium phosphates as cell carriers for bone tissue engineering
Daou, Farah;Cochis, Andrea;Rimondini, Lia;
2026-01-01
Abstract
Scaffolds in bone tissue engineering (BTE) function as temporary 3D support for cells, recreating a bone-like microenvironment that promotes their adhesion, proliferation, and differentiation. Calcium phosphate (CaP) ceramics are widely used in orthopedics owing to their similarity to biological apatite, while ion doping and bioactive glass addition further enhance biological activity and mechanical stability. Here, composite scaffolds were fabricated from Sr,Mg-doped CaP combined with pristine or Sr,Mg-doped mesoporous bioactive glass nanoparticles (MBGNs). MBGNs incorporation promoted α -tricalcium phosphate phase formation and significantly improved the compressive strength via reduced microporosity through liquid-phase sintering without compromising the macroporosity. Bioactivity was confirmed under dynamic perfusion. Obtained scaffolds supported attachment and growth of human bone marrow stromal cells and endothelial cells, with enhanced pro-angiogenic properties. These results highlight Sr,Mg-doped CaP/MBGN composites as a mechanically reinforced, osteogenic and pro-angiogenic platform for BTE.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
