Development of multidentate ligands selective for metal ions used in diagnostic or theranostic imaging

Prevention is essential for maintaining health, with early disease detection being particularly critical for conditions like cancer, where early diagnosis greatly improves recovery chances. Diagnostic imaging plays a vital role by enabling detailed internal examinations. Metal complexes have significantly advanced prevention and treatment efforts. These complexes, composed of a metal ion chelated by organic ligands, are designed to minimize toxicity and are used in diagnostics, radiotherapy, and theranostics, combining therapeutic and diagnostic functions. Functionalizing these ligands with biological vectors, like peptides or antibodies, has further improved targeted delivery and reduced side effects. Developing metal-complex-based drugs involves optimizing metal and ligand properties to ensure stability and effectiveness. This thesis focuses on designing innovative ligands to enhance imaging techniques such as MRI and PET and to advance therapeutic methods, including targeted alpha and beta therapies