BACKGROUND: The role of prophylactic central neck dissection (pCND) in differentiated thyroid cancer (DTC) is still controversial. METHODS: In a cohort of 274 DTC cN0 patients with a high rate of tumor recurrence, who underwent total thyroidectomy with or without pCND, clinical and histopathological features were retrospectively analyzed. RESULTS: In our cohort, no clinical or histopathological features are able to predict the presence of central lymph node metastases (CLNM) at diagnosis, which instead represents the only variable significantly associated with a higher risk of long-term tumor relapse, independently from age, sex, BMI and radioiodine treatment (OR=1.03, 95% CI: 1.002-1.074, P<0.05). Moreover, our study demonstrates that pCND does not significantly increase the risk of post-surgical complications. CONCLUSIONS: In our setting, pCND could have a key role in the management of DTC. The risks and benefits of pCND should be evaluated for each population to make the most appropriate therapeutic choice.
Prophylactic central neck dissection in differentiated thyroid cancer: risks and benefits in a population with a high rate of tumor recurrence
RAIA, Melissa;MELE, Chiara;PAGANO, Loredana;DELL'ERA, Valeria;MARZULLO, Paolo;AIMARETTI, Gianluca;GARZARO, Massimiliano;ALUFFI VALLETTI, Paolo
2025-01-01
Abstract
BACKGROUND: The role of prophylactic central neck dissection (pCND) in differentiated thyroid cancer (DTC) is still controversial. METHODS: In a cohort of 274 DTC cN0 patients with a high rate of tumor recurrence, who underwent total thyroidectomy with or without pCND, clinical and histopathological features were retrospectively analyzed. RESULTS: In our cohort, no clinical or histopathological features are able to predict the presence of central lymph node metastases (CLNM) at diagnosis, which instead represents the only variable significantly associated with a higher risk of long-term tumor relapse, independently from age, sex, BMI and radioiodine treatment (OR=1.03, 95% CI: 1.002-1.074, P<0.05). Moreover, our study demonstrates that pCND does not significantly increase the risk of post-surgical complications. CONCLUSIONS: In our setting, pCND could have a key role in the management of DTC. The risks and benefits of pCND should be evaluated for each population to make the most appropriate therapeutic choice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
