A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Scott RA;Freitag DF;Li L;Chu AY;Surendran P;Young R;Grarup N;Stancáková A;Chen Y;Varga TV;Yaghootkar H;Luan J;Zhao JH;Willems SM;Wessel J;Wang S;Maruthur N;Michailidou K;Pirie A;van der Lee SJ;Gillson C;Al Olama AA;Amouyel P;Arriola L;Arveiler D;Aviles-Olmos I;Balkau B;Barricarte A;Barroso I;Garcia SB;Bis JC;Blankenberg S;Boehnke M;Boeing H;Boerwinkle E;Borecki IB;Bork-Jensen J;Bowden S;Caldas C;Caslake M;CVD50 consortium.;Cupples LA;Cruchaga C;Czajkowski J;den Hoed M;Dunn JA;Earl HM;Ehret GB;Ferrannini E;Ferrieres J;Foltynie T;Ford I;Forouhi NG;Gianfagna F;Gonzalez C;Grioni S;Hiller L;Jansson JH;Jørgensen ME;Jukema JW;Kaaks R;Kee F;Kerrison ND;Key TJ;Kontto J;Kote-Jarai Z;Kraja AT;Kuulasmaa K;Kuusisto J;Linneberg A;Liu C;Marenne G;Mohlke KL;Morris AP;Muir K;Müller-Nurasyid M;Munroe PB;Navarro C;Nielsen SF;Nilsson PM;Nordestgaard BG;Packard CJ;Palli D;Panico S;Peloso GM;Perola M;Peters A;Poole CJ;Quirós JR;Rolandsson O;Sacerdote C;Salomaa V;Sánchez MJ;Sattar N;Sharp SJ;Sims R;Slimani N;Smith JA;Thompson DJ;Trompet S;Tumino R;van der A DL;van der Schouw YT;Virtamo J;Walker M;Walter K;GERAD_EC Consortium.;Neurology Working Group of the Cohorts for Heart.;Aging Research in Genomic Epidemiology (CHARGE).;Alzheimer’s Disease Genetics Consortium.;Pancreatic Cancer Cohort Consortium.;European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD).;EPIC-InterAct.;Abraham JE;Amundadottir LT;Aponte JL;Butterworth AS;Dupuis J;Easton DF;Eeles RA;Erdmann J;Franks PW;Frayling TM;Hansen T;Howson JM;Jørgensen T;Kooner J;Laakso M;Langenberg C;McCarthy MI;Pankow JS;Pedersen O;Riboli E;Rotter JI;Saleheen D;Samani NJ;Schunkert H;Vollenweider P;O'Rahilly S;CHARGE consortium.;CHD Exome+ Consortium.;CARDIOGRAM Exome Consortium.;Deloukas P;Danesh J;Goodarzi MO;Kathiresan S;Meigs JB;Ehm MG;Wareham NJ;Waterworth DM.

2016-01-01