Background: Serum albumin-to-globulin ratio (AGR) has been shown to be associated with poor prognosis in different malignancies. In this study we aimed to evaluate the predictive value of preoperative AGRfor oncological outcomes in patients with radiation recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP) Methods: A retrospective review of 214 consecutive patients with radiation recurrent PCa who underwent SRP at five referral centers. Levels of albumin and globulin were obtained before SRPand used to calculate the preoperative AGRlevel. The optimal cut off value of preoperative AGRwas 1.4. Univariable and multivariable Cox regression analyses were performed. Results: Overall 89 (41.6%) patients had a low preoperative AGR. Low serum AGRwas associated with biochemical recurrence (BCR) in univariable Cox regression analysis (HR1.60, 95%CI1.06-2.43, P=0.026). When adjusted for the effects of established preoperative and postoperative clinicopathologic confounders in different multivariable Cox regression models, this association did not retain its statistical significance. Moreover, preoperative AGR was not associated with metastasis free survival (P=0.21), overall survival (P=0.91) or cancer specific survival (P=0.61). Conclusions: In patients with radiation recurrent PCa undergoing SRP, low preoperative AGRwas associated with the risk of BCRonly in univariable analysis. There was no association with metastasis or survival outcomes. Further studies are needed to evaluate this biomarker in the setting of primary PCa and to identify the patients most likely to benefit from a local therapy.
Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer
Palumbo C.;
2021-01-01
Abstract
Background: Serum albumin-to-globulin ratio (AGR) has been shown to be associated with poor prognosis in different malignancies. In this study we aimed to evaluate the predictive value of preoperative AGRfor oncological outcomes in patients with radiation recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP) Methods: A retrospective review of 214 consecutive patients with radiation recurrent PCa who underwent SRP at five referral centers. Levels of albumin and globulin were obtained before SRPand used to calculate the preoperative AGRlevel. The optimal cut off value of preoperative AGRwas 1.4. Univariable and multivariable Cox regression analyses were performed. Results: Overall 89 (41.6%) patients had a low preoperative AGR. Low serum AGRwas associated with biochemical recurrence (BCR) in univariable Cox regression analysis (HR1.60, 95%CI1.06-2.43, P=0.026). When adjusted for the effects of established preoperative and postoperative clinicopathologic confounders in different multivariable Cox regression models, this association did not retain its statistical significance. Moreover, preoperative AGR was not associated with metastasis free survival (P=0.21), overall survival (P=0.91) or cancer specific survival (P=0.61). Conclusions: In patients with radiation recurrent PCa undergoing SRP, low preoperative AGRwas associated with the risk of BCRonly in univariable analysis. There was no association with metastasis or survival outcomes. Further studies are needed to evaluate this biomarker in the setting of primary PCa and to identify the patients most likely to benefit from a local therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
