: T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.
T Lymphocytes in Parkinson's Disease
Contaldi, Elena;Magistrelli, Luca;Comi, Cristoforo
2022-01-01
Abstract
: T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.File in questo prodotto:
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