Bittorf and colleagues present the validation of a qPCR-based method to detect human genomic DNA in mouse organs following European and international guidelines. They further introduce a biodistribution study of a medicinal product consisting of lentiviral-transduced BOECs from hemophilic patients to investigate the toxicokinetic safety profile for clinical translation.
Regulatory-Compliant Validation of a Highly Sensitive qPCR for Biodistribution Assessment of Hemophilia A Patient Cells
Merlin S.Methodology
;Olgasi C.Methodology
;Follenzi A.Penultimo
Conceptualization
;
2020-01-01
Abstract
Bittorf and colleagues present the validation of a qPCR-based method to detect human genomic DNA in mouse organs following European and international guidelines. They further introduce a biodistribution study of a medicinal product consisting of lentiviral-transduced BOECs from hemophilic patients to investigate the toxicokinetic safety profile for clinical translation.File in questo prodotto:
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