A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38). RI Marzioni, Marco/A-8153-2011; croce', saveria /E-2565-2011; Peltekian, Kevork/D-1083-2010
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
Rigamonti C;
2010-01-01
Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38). RI Marzioni, Marco/A-8153-2011; croce', saveria /E-2565-2011; Peltekian, Kevork/D-1083-2010File in questo prodotto:
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PBC and genome-wide metanalyses, Nature Genetics 2010.pdf
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