IRIS
RIZZI, Menico
 Distribuzione geografica
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Continente #
EU - Europa 3.230
NA - Nord America 3.150
AS - Asia 2.020
SA - Sud America 360
AF - Africa 49
Continente sconosciuto - Info sul continente non disponibili 8
OC - Oceania 1
Totale 8.818
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Nazione #
US - Stati Uniti d'America 3.073
IE - Irlanda 804
SG - Singapore 799
DE - Germania 513
IT - Italia 495
CN - Cina 437
SE - Svezia 435
HK - Hong Kong 341
UA - Ucraina 298
BR - Brasile 292
RU - Federazione Russa 209
VN - Vietnam 186
FI - Finlandia 167
IN - India 103
GB - Regno Unito 79
CZ - Repubblica Ceca 52
FR - Francia 49
CA - Canada 47
KR - Corea 35
PL - Polonia 27
AR - Argentina 26
TR - Turchia 24
BJ - Benin 21
MX - Messico 21
AT - Austria 18
JP - Giappone 18
BE - Belgio 17
ID - Indonesia 17
ES - Italia 16
ZA - Sudafrica 14
BD - Bangladesh 13
EC - Ecuador 13
NL - Olanda 13
CH - Svizzera 11
IR - Iran 11
EU - Europa 8
MA - Marocco 8
CO - Colombia 7
SA - Arabia Saudita 7
CL - Cile 6
EE - Estonia 6
IQ - Iraq 5
LT - Lituania 5
PE - Perù 5
PY - Paraguay 5
AE - Emirati Arabi Uniti 4
DK - Danimarca 4
RO - Romania 4
UZ - Uzbekistan 4
AZ - Azerbaigian 3
IL - Israele 3
VE - Venezuela 3
BO - Bolivia 2
EG - Egitto 2
JO - Giordania 2
KZ - Kazakistan 2
TH - Thailandia 2
BB - Barbados 1
BG - Bulgaria 1
BS - Bahamas 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GD - Grenada 1
HR - Croazia 1
IS - Islanda 1
JM - Giamaica 1
KE - Kenya 1
LB - Libano 1
LU - Lussemburgo 1
MK - Macedonia 1
NG - Nigeria 1
NI - Nicaragua 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PA - Panama 1
PR - Porto Rico 1
PT - Portogallo 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
SV - El Salvador 1
TN - Tunisia 1
TW - Taiwan 1
UY - Uruguay 1
Totale 8.818
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Città #
Dublin 804
Jacksonville 567
Hong Kong 335
Dearborn 266
Chandler 223
Beijing 220
Singapore 213
Ashburn 186
Wilmington 125
Piemonte 119
Ann Arbor 113
Lawrence 99
Princeton 99
Moscow 95
San Mateo 82
Los Angeles 78
Ho Chi Minh City 66
Munich 65
Buffalo 64
Bremen 60
Novara 52
Brno 50
Andover 45
New York 42
Hanoi 41
São Paulo 38
Milan 35
Boardman 31
Seoul 30
Houston 29
Santa Clara 23
Cotonou 21
Toronto 21
Turin 21
Dallas 20
Frankfurt am Main 20
Vercelli 19
Brooklyn 18
Guangzhou 18
Nanjing 18
Warsaw 18
Woodbridge 18
Brussels 17
Redondo Beach 17
Kunming 16
Tianjin 16
Helsinki 15
London 15
Strasbourg 15
The Dalles 15
Tokyo 15
Kocaeli 14
Nuremberg 14
Denver 13
Orem 13
Assago 12
Chennai 12
Montreal 12
Phoenix 12
Seattle 12
Chicago 11
Hefei 11
Mexico City 11
Philadelphia 11
Poplar 11
Rio de Janeiro 11
Carmagnola 10
Johannesburg 10
Stockholm 10
Ankara 9
Guayaquil 9
Jakarta 9
Norwalk 9
Torino 9
Bexley 8
Haiphong 8
Monmouth Junction 8
Nanchang 8
Turku 8
Ardabil 7
Atlanta 7
Da Nang 7
Naples 7
San Francisco 7
Vienna 7
Amsterdam 6
Bologna 6
Cambridge 6
Curitiba 6
Fort Worth 6
Genoa 6
Hải Dương 6
Jinan 6
Lugano 6
Rome 6
Boston 5
Brasília 5
Casalecchio Di Reno 5
Leawood 5
Manchester 5
Totale 5.070
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Nome #
Structural investigations on Zmp1 from Mycobacterium tuberculosis, a Zn-metalloprotease that prevents inflammasome activation and phagosome maturation 195
Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled onto damaged DNA 142
A nicotinamide phosphoribosyltransferase–GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus 129
Crystal structure of human nicotinic acid phosphoribosyltransferase 121
Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family 119
Absolute structure and structure-function relationships of 4R,2’R and 4S,2’S Pidotimod 114
Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis 113
Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase 111
Hit discovery of Mycobacterium tuberculosis inosine 5′-monophosphate dehydrogenase, GuaB2, inhibitors 110
Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis 108
Biochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants 107
A NOVEL DEAMIDO-NAD BINDING SITE REVEALED BY THE TRAPPED NAD-ADENYLATE INTERMEDIATE IN THE NAD SYNTHETASE STRUCTURE 106
Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair 105
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia. 104
Structure of Thermococcus litoralis trans-3-hydroxy-L-proline dehydratase in the free and substrate-complexed form 104
Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific inhibition? 102
Targeting Genome Integrity in Mycobacterium Tuberculosis: From Nucleotide Synthesis to DNA Replication and Repair 100
Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein 98
Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement 97
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells 97
Mycobacterium tuberculosis UvrB forms dimers in solution and interacts with UvrA in the absence of ligands 96
European education corridors: opportunity for academic solidarity 96
Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity 94
Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid 92
Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1 92
Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase 91
Crystal structure of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB) in complex with the inhibitor O-isobutenyl oxalylhydroxamate 91
Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment 91
Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control RID D-5386-2011 90
Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates. 90
Biochemical characterization of Plasmodium falciparum CDPK4 and Anopheles gambiae TDO: two antimalarial targets 89
Every OGT is illuminated … By fluorescent and synchrotron lights 88
Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues 86
Human alpha-thrombin inhibition by the active site titrant Nalpha-(N,N-dimethylcarbamoyl)-alpha-azalysine-p-nitrophenyl-ester: a comparative kinetic and x-ray crystallographic study 86
New structures of allosteric proteins reveal remarkable 86
Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD(+) biosynthesis 86
Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia 85
Crystal structure of human kynurenine aminotransferase I 85
Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3 85
The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis 85
A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis 84
Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets 83
Allosteric regulation of Bacillus subtilis NAD kinase by quinolinic acid 83
Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method 83
Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer 83
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent 82
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase 81
A covalent modification of NADP(+) revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase RID D-7098-2011 81
Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: An x-ray crystallographic study RID D-5386-2011 81
A selective competitive inhibitor of aldehyde dehydrogenase 1A3 hinders cancer cell growth, invasiveness and stemness in vitro 81
Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation 80
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis 80
Human kynurenine aminotransferase II--reactivity with substrates and inhibitors 79
AI is a viable alternative to high throughput screening: a 318-target study 78
Crystal structure of D-amino acis oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2 78
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis 78
Expression, purification and characterisation of haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB) 78
Functional modulation by lactate of myoglobin. A monomeric allosteric hemoprotein 77
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis 77
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety 76
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor 76
Sulfide recognition in Lucina pectinata hemoglobin I: a crystallographic study 75
Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor 75
STRUCTURE DETERMINATION OF TWO PLASMA PROTEINS: TRANSTHYRETIN AND RETINOL BINDING PROTEIN 74
Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis 74
The Potent Antiplasmodial Calmodulin-Antagonist Trifluoperazine Inhibits Plasmodium Falciparum Calcium-Dependent Protein Kinase 4. 74
+Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis 74
Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase 74
Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity RID D-2548-2009 74
Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis 74
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism 73
Crystal structure of Escherichia coli pyruvate kinase type-I: molecular basis of the allosteric transition 72
Structure of the sulfide-reactive hemoglobin from the clam Lucina pectinata crystallographic analysis at 1.5 Å resolution 72
The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis 72
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology 71
Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents 70
Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH 70
Analysis of the wild-type and mutant genes encoding the enzyme mosquito kynurenine monooxygenase of the yellow fever mosquito Aedes aegypti 70
The integration of AlphaFold-predicted and crystal structures of human trans-3-hydroxy-l-proline dehydratase reveals a regulatory catalytic mechanism 69
Human alpha-thrombin inhibition by the highly selective compounds: N-ethoxycarbonyl-D-Phe-Pro-alpha-azalysinep-nitrophenylester,N-carbobenzoxy-Pro alpha-azalysine-p-nitrophenyl-ester and Nalpha-(N,N-dimethylcarbamoyl)-?-azalysine-p-nitrophenyl-ester: a kinetic, thermodynamic and x-ray crystallographic study 69
CRYSTAL STRUCTURE OF NH3-DEPENDENT NAD SYNTHETASE FROM BACILLUS SUBTILIS 68
Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network 67
The structure of Rigidoporus lignosus laccase containing a full complement of copper ions, reveals an asymmetrical arrangement for the T3 copper pair 67
Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase 65
Structure of human NMN adenylyltransferase - A key nuclear enzyme for NAD homeostasis 65
Nonvertebrate oxygen carrier hemoproteins: structural bases for reactivity 63
The synthesis of kynurenic acid in mammals: an updated kynurenine aminotransferase structural KATalogue 63
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme 61
Structures of citrate synthase and malate dehydrogenase ofMycobacterium tuberculosis 61
Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline 61
Cryo-EM-based structural investigation of Mycobacterium tuberculosis Nucleotide Excision Repair 60
X-ray crystallography, mass spectrometry and single crystal microspectrophotometry: A multidisciplinary characterization of catechol 1,2 dioxygenase 60
Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli 60
Signalling Inhibitors Against Mycobacterium tuberculosis - Early Days of a New Therapeutic Concept in Tuberculosis 59
Determination of H2S solubility via the reaction with ferric hemoglobin I from the bivalve mollusc Lucina pectinata 57
Enhancement of the HIV-1 inhibitory activity of RANTES by modification of the N-terminal region: dissociation from CCR5 activation 57
The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action RID D-2548-2009 RID F-6175-2011 56
Target Flexibility: An Emerging Consideration in Drug Discovery and Design RID A-8008-2011 55
The ATP-dependent nucleosome remodeling factor ISWI physically interacts with Poly (ADP-ribose)polymerase-1 55
Structural investigations on M. tuberculosis proteins involved in DNA repair 54
Totale 8.335
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Categoria #
all - tutte 48.528
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.528
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021415 0 0 0 0 0 15 103 9 107 42 115 24
2021/2022698 38 40 130 54 27 4 56 8 55 16 110 160
2022/20231.758 128 75 110 41 150 183 39 103 835 14 48 32
2023/2024529 44 52 53 14 98 5 83 11 3 20 41 105
2024/20251.544 54 10 94 22 36 183 113 103 316 129 156 328
2025/20261.978 250 182 324 717 441 64 0 0 0 0 0 0
Totale 8.916