IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 2.540
NA - Nord America 2.280
AS - Asia 1.410
SA - Sud America 221
AF - Africa 52
Continente sconosciuto - Info sul continente non disponibili 6
Totale 6.509
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Nazione #
US - Stati Uniti d'America 2.214
IE - Irlanda 568
IT - Italia 494
SG - Singapore 450
DE - Germania 420
CN - Cina 313
SE - Svezia 311
HK - Hong Kong 238
UA - Ucraina 185
BR - Brasile 164
FI - Finlandia 145
RU - Federazione Russa 131
GB - Regno Unito 105
VN - Vietnam 105
IN - India 101
TR - Turchia 63
CA - Canada 44
FR - Francia 38
EE - Estonia 27
IR - Iran 26
AR - Argentina 22
BE - Belgio 21
JP - Giappone 19
PL - Polonia 19
BJ - Benin 17
KR - Corea 17
ES - Italia 15
CZ - Repubblica Ceca 14
MX - Messico 14
AT - Austria 13
ID - Indonesia 12
NL - Olanda 12
ZA - Sudafrica 12
BD - Bangladesh 11
EC - Ecuador 10
LT - Lituania 10
PK - Pakistan 8
SA - Arabia Saudita 8
CL - Cile 7
IQ - Iraq 7
MA - Marocco 7
UZ - Uzbekistan 7
UY - Uruguay 6
AZ - Azerbaigian 5
EU - Europa 5
IL - Israele 5
VE - Venezuela 5
AE - Emirati Arabi Uniti 4
CI - Costa d'Avorio 3
EG - Egitto 3
BG - Bulgaria 2
CH - Svizzera 2
CO - Colombia 2
DZ - Algeria 2
HN - Honduras 2
JO - Giordania 2
KE - Kenya 2
PE - Perù 2
PY - Paraguay 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TN - Tunisia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GT - Guatemala 1
HU - Ungheria 1
JM - Giamaica 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LV - Lettonia 1
NG - Nigeria 1
NP - Nepal 1
OM - Oman 1
PA - Panama 1
SV - El Salvador 1
TH - Thailandia 1
TJ - Tagikistan 1
TT - Trinidad e Tobago 1
Totale 6.509
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Città #
Dublin 568
Jacksonville 328
Hong Kong 235
Dearborn 190
Singapore 185
Ashburn 148
Beijing 143
Chandler 118
Munich 112
Ann Arbor 104
Piemonte 88
Los Angeles 77
Wilmington 69
Novara 67
Lawrence 64
Princeton 64
San Mateo 63
Moscow 49
Helsinki 44
New York 42
Bremen 40
Buffalo 33
Andover 32
Turku 32
Dallas 28
Ho Chi Minh City 27
Milan 27
Ankara 25
Hanoi 24
Hefei 22
São Paulo 22
Turin 21
Frankfurt am Main 20
Santa Clara 20
Brussels 19
Montreal 19
Vercelli 19
London 18
Cotonou 17
Chennai 15
Houston 15
Redondo Beach 15
Seoul 15
Brno 14
Orem 14
Warsaw 14
Zola Predosa 14
Falkenstein 13
Poplar 13
Boardman 12
Kocaeli 12
Tokyo 12
Toronto 12
Chicago 11
Norwalk 11
Phoenix 11
Seattle 11
Stockholm 11
Ardabil 10
Atlanta 10
Brooklyn 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Denver 9
Treviso 9
Fairfield 8
Johannesburg 8
Mexico City 8
Berlin 7
Calvisano 7
Jakarta 7
Jinan 7
Reggio Emilia 7
Tashkent 7
Tianjin 7
Torino 7
Amsterdam 6
Bexley 6
Da Nang 6
Imola 6
Kunming 6
Manchester 6
Nanchang 6
Nuremberg 6
Rio de Janeiro 6
San Francisco 6
Asti 5
Baku 5
Boston 5
Leawood 5
Mülheim 5
Noicattaro 5
Roubaix 5
San Jose 5
Secaucus 5
Shenyang 5
Trieste 5
Bari 4
Biella 4
Totale 3.749
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Nome #
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 145
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 138
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 133
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 130
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 129
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 127
A primer of deuterium in drug design 119
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 118
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 115
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 114
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 113
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 112
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 112
Deuterium in drug discovery: progress, opportunities and challenges 111
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 111
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 106
Transition-Metal-Free Direct Arylation of Anilines 103
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 101
Estrogenic analogues synthesized by click chemistry 101
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 101
Applications of deuterium in medicinal chemistry 101
null 100
TRPV1 Modulator Compounds 99
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 97
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 97
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 96
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 96
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 96
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 96
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 96
A concise entry into nonsymmetrical alkyl polyamines 95
An aryne-based three-component access to α-aroylamino amides 95
Essential Medicinal Chemistry of Essential Medicines 95
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 94
A Concise Entry into Nonsymmetrical Alkyl Polyamines 91
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 90
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 90
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 87
PI3K keeps the balance between metabolism and cancer 84
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 83
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 83
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 83
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 82
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 82
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 81
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 81
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 81
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 80
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 78
Soft drugs for dermatological applications: recent trends 78
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 76
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 76
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 73
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 73
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 73
Synthesis and biological evaluation of combretatriazoles 72
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 70
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 70
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 69
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 69
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 68
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 67
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 67
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 66
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 65
Synthesis and biological evaluation of combretatriazoles 62
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 61
Medicinal chemistry of combretastatin A4: present and future directions 58
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 57
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 56
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 55
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 54
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 48
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 45
Moonlighting Proteins Are Important Players in Cancer Immunology 45
Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis 32
Totale 6.653
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Categoria #
all - tutte 33.562
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.562
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021322 0 0 0 0 0 33 69 22 82 36 65 15
2021/2022559 34 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.217 29 39 73 60 53 116 122 119 192 78 66 270
2025/20261.534 233 117 229 473 347 135 0 0 0 0 0 0
Totale 6.653