IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 1.816
NA - Nord America 1.538
AS - Asia 437
Continente sconosciuto - Info sul continente non disponibili 6
AF - Africa 1
SA - Sud America 1
Totale 3.799
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Nazione #
US - Stati Uniti d'America 1.529
IE - Irlanda 568
IT - Italia 329
SE - Svezia 300
DE - Germania 266
UA - Ucraina 174
CN - Cina 147
FI - Finlandia 83
IN - India 80
HK - Hong Kong 74
SG - Singapore 62
GB - Regno Unito 42
TR - Turchia 32
IR - Iran 25
BE - Belgio 16
CZ - Repubblica Ceca 14
CA - Canada 9
FR - Francia 9
JP - Giappone 7
EU - Europa 5
RU - Federazione Russa 5
VN - Vietnam 5
NL - Olanda 4
AT - Austria 3
IL - Israele 3
RO - Romania 2
A2 - ???statistics.table.value.countryCode.A2??? 1
EG - Egitto 1
IQ - Iraq 1
KR - Corea 1
LT - Lituania 1
PE - Perù 1
Totale 3.799
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Città #
Dublin 568
Jacksonville 327
Dearborn 190
Chandler 118
Ann Arbor 104
Piemonte 88
Hong Kong 74
Wilmington 69
Lawrence 64
Princeton 64
San Mateo 63
Beijing 50
Bremen 40
Andover 32
Singapore 32
Ashburn 28
Hefei 22
Ankara 17
Helsinki 17
Brussels 16
Turin 16
Novara 15
Brno 14
Zola Predosa 14
Dallas 12
Kocaeli 12
Boardman 11
Norwalk 11
Ardabil 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Milan 9
Munich 9
Fairfield 8
Seattle 8
Berlin 7
Calvisano 7
Jinan 7
Torino 7
Toronto 7
Imola 6
Kunming 6
Nanchang 6
Asti 5
Houston 5
Leawood 5
Mülheim 5
Noicattaro 5
Shenyang 5
Trieste 5
Bari 4
Biella 4
Cassano Magnago 4
Cerano 4
Dong Ket 4
London 4
Vercelli 4
Zanjan 4
Ashdod 3
Augusta 3
Barzago 3
Busto Arsizio 3
Chengdu 3
Chongqing 3
Grafing 3
Kecioeren 3
Nonantola 3
Rankweil 3
Wenzhou 3
Cambridge 2
Cameriano 2
Como 2
Des Moines 2
Genova 2
Grignasco 2
Guangzhou 2
Gunzenhausen 2
Hebei 2
Moncalieri 2
Napoli 2
New York 2
Nijmegen 2
Rho 2
Sacramento 2
San Giuliano Milanese 2
Shanghai 2
Vergiate 2
Wachtberg 2
Winnipeg 2
Wuhan 2
Aachen 1
Absecon 1
Aiello del Sabato 1
Alessandria 1
Altavilla Monferrato 1
Amsterdam 1
Baghdad 1
Baotou 1
Bengaluru 1
Totale 2.366
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Nome #
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 101
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 96
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 88
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 87
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 82
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 82
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 81
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 80
Transition-Metal-Free Direct Arylation of Anilines 77
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 77
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 75
A primer of deuterium in drug design 75
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 73
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 71
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 71
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 71
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 70
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 70
Applications of deuterium in medicinal chemistry 69
TRPV1 Modulator Compounds 69
The Essential Medicinal Chemistry of Essential Medicines 68
An aryne-based three-component access to α-aroylamino amides 67
PI3K keeps the balance between metabolism and cancer 66
A concise entry into nonsymmetrical alkyl polyamines 65
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 65
Estrogenic analogues synthesized by click chemistry 64
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 64
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 63
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 62
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 60
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 59
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 59
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 58
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 57
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 56
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 54
A Concise Entry into Nonsymmetrical Alkyl Polyamines 53
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 53
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 53
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 52
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 51
Soft drugs for dermatological applications: recent trends 51
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 50
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 49
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 49
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 48
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 47
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 47
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 46
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 45
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 45
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 44
Medicinal chemistry of combretastatin A4: present and future directions 43
Synthesis and biological evaluation of combretatriazoles 42
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 41
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 41
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 40
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 39
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 39
Synthesis and biological evaluation of combretatriazoles 38
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 37
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 35
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 35
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 32
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 29
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 26
Moonlighting Proteins Are Important Players in Cancer Immunology 26
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 24
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 11
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 7
Deuterium in drug discovery: progress, opportunities and challenges 3
Totale 3.923
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Categoria #
all - tutte 18.217
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.217
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020793 2 4 64 4 124 118 176 35 63 98 94 11
2020/2021515 67 2 58 5 61 33 69 22 82 36 65 15
2021/2022559 34 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/202521 21 0 0 0 0 0 0 0 0 0 0 0
Totale 3.923