IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 3.349
NA - Nord America 2.824
AS - Asia 1.916
SA - Sud America 249
AF - Africa 66
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 1
Totale 8.411
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Nazione #
US - Stati Uniti d'America 2.733
RU - Federazione Russa 737
IE - Irlanda 570
SG - Singapore 568
IT - Italia 552
CN - Cina 467
DE - Germania 434
SE - Svezia 312
HK - Hong Kong 249
VN - Vietnam 243
UA - Ucraina 187
BR - Brasile 178
FI - Finlandia 149
FR - Francia 121
GB - Regno Unito 119
IN - India 115
TR - Turchia 69
CA - Canada 58
AR - Argentina 28
IR - Iran 26
BD - Bangladesh 25
EE - Estonia 25
JP - Giappone 24
KR - Corea 23
PL - Polonia 23
BE - Belgio 21
MX - Messico 19
ES - Italia 18
NL - Olanda 18
BJ - Benin 17
CZ - Repubblica Ceca 17
ZA - Sudafrica 15
AT - Austria 13
ID - Indonesia 13
SA - Arabia Saudita 13
IQ - Iraq 12
CL - Cile 11
LT - Lituania 10
PK - Pakistan 9
EC - Ecuador 8
UZ - Uzbekistan 8
VE - Venezuela 8
AE - Emirati Arabi Uniti 7
MA - Marocco 7
AZ - Azerbaigian 6
TH - Thailandia 6
UY - Uruguay 6
EU - Europa 5
IL - Israele 5
KE - Kenya 5
PH - Filippine 5
CO - Colombia 4
DZ - Algeria 4
EG - Egitto 4
JM - Giamaica 4
RO - Romania 4
TN - Tunisia 4
TW - Taiwan 4
CI - Costa d'Avorio 3
JO - Giordania 3
MD - Moldavia 3
PE - Perù 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
BG - Bulgaria 2
CH - Svizzera 2
ET - Etiopia 2
GA - Gabon 2
HN - Honduras 2
HU - Ungheria 2
MY - Malesia 2
NP - Nepal 2
PA - Panama 2
PY - Paraguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
GR - Grecia 1
GT - Guatemala 1
KG - Kirghizistan 1
KH - Cambogia 1
KZ - Kazakistan 1
LB - Libano 1
LV - Lettonia 1
MM - Myanmar 1
NG - Nigeria 1
NI - Nicaragua 1
OM - Oman 1
RS - Serbia 1
SI - Slovenia 1
Totale 8.409
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Città #
Dublin 570
Jacksonville 329
San Jose 268
Singapore 244
Hong Kong 243
Dearborn 190
Ashburn 182
Beijing 150
Chandler 118
Munich 109
Ann Arbor 104
Los Angeles 88
Piemonte 88
Moscow 78
Council Bluffs 71
Wilmington 71
Lauterbourg 64
Lawrence 64
Princeton 64
San Mateo 63
Hanoi 61
Novara 61
New York 59
Ho Chi Minh City 53
Helsinki 49
Bremen 40
Dallas 36
Frankfurt am Main 33
Santa Clara 33
Andover 32
Buffalo 32
Milan 31
Turku 31
Ankara 25
São Paulo 25
Turin 25
Montreal 24
Hefei 22
Orem 21
Chennai 20
London 20
Brussels 19
Vercelli 18
Warsaw 18
Cotonou 17
Houston 17
Chicago 16
Seoul 16
Tornaco 16
Redondo Beach 15
Toronto 15
Brno 14
Da Nang 14
Falkenstein 14
Phoenix 14
Tokyo 14
Zola Predosa 14
Denver 13
Poplar 13
Tianjin 13
Atlanta 12
Boardman 12
Kocaeli 12
Norwalk 11
Seattle 11
Stockholm 11
Amsterdam 10
Ardabil 10
Brooklyn 10
Guangzhou 10
Hillsboro 10
Johannesburg 10
Manchester 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Mexico City 9
The Dalles 9
Treviso 9
Fairfield 8
Tashkent 8
Berlin 7
Bexley 7
Calvisano 7
Jakarta 7
Jinan 7
Kunming 7
Nuremberg 7
Reggio Emilia 7
San Francisco 7
Torino 7
Baghdad 6
Baku 6
Cambridge 6
Chengdu 6
Imola 6
Nanchang 6
Rio de Janeiro 6
Asti 5
Boston 5
Totale 4.515
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Nome #
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 180
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 171
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 168
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 167
Deuterium in drug discovery: progress, opportunities and challenges 162
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 160
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 160
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 158
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 153
Applications of deuterium in medicinal chemistry 145
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 143
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 142
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 135
A primer of deuterium in drug design 135
Estrogenic analogues synthesized by click chemistry 133
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 132
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 131
Essential Medicinal Chemistry of Essential Medicines 131
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 130
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 130
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 129
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 127
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 126
TRPV1 Modulator Compounds 125
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 121
An aryne-based three-component access to α-aroylamino amides 121
A concise entry into nonsymmetrical alkyl polyamines 120
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 120
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 120
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 119
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 119
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 118
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 117
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 117
Transition-Metal-Free Direct Arylation of Anilines 116
A Concise Entry into Nonsymmetrical Alkyl Polyamines 113
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 112
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 110
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 109
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 109
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 108
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 107
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 106
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 104
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 104
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 103
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 101
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 100
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 99
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 99
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 98
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 98
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 97
PI3K keeps the balance between metabolism and cancer 97
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 97
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 96
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 96
Soft drugs for dermatological applications: recent trends 96
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 94
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 93
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 93
Synthesis and biological evaluation of combretatriazoles 90
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 85
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 82
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 79
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 78
Synthesis and biological evaluation of combretatriazoles 76
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 73
Medicinal chemistry of combretastatin A4: present and future directions 72
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 70
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 68
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 68
Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis 63
Moonlighting Proteins Are Important Players in Cancer Immunology 59
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 58
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 51
Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery 38
Sustainable Photocatalytic Synthesis of Glitazones via Riboflavin Tetraacetate 25
Preparation of biphenyl amides as dual-targeting SOCE/DHODH inhibitors 5
Deuterated active pharmaceutical ingredients 2
Totale 8.562
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Categoria #
all - tutte 38.582
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.582
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202115 0 0 0 0 0 0 0 0 0 0 0 15
2021/2022559 34 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.199 29 39 73 60 53 116 122 111 188 76 66 266
2025/20263.461 227 114 223 469 339 221 430 569 231 364 199 75
Totale 8.562