IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
NA - Nord America 3.934
EU - Europa 3.456
AS - Asia 1.960
SA - Sud America 269
Continente sconosciuto - Info sul continente non disponibili 159
AF - Africa 68
OC - Oceania 1
Totale 9.847
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Nazione #
US - Stati Uniti d'America 3.779
RU - Federazione Russa 737
IT - Italia 605
SG - Singapore 574
IE - Irlanda 571
CN - Cina 478
DE - Germania 437
SE - Svezia 313
HK - Hong Kong 259
VN - Vietnam 243
BR - Brasile 188
UA - Ucraina 187
FI - Finlandia 149
GB - Regno Unito 143
FR - Francia 130
IN - India 117
CA - Canada 84
TR - Turchia 69
BD - Bangladesh 33
AR - Argentina 31
EE - Estonia 29
IR - Iran 26
JP - Giappone 26
BE - Belgio 24
MX - Messico 24
PL - Polonia 24
KR - Corea 23
ES - Italia 20
NL - Olanda 19
BJ - Benin 17
CZ - Repubblica Ceca 17
ZA - Sudafrica 16
ID - Indonesia 14
AT - Austria 13
SA - Arabia Saudita 13
IQ - Iraq 12
CL - Cile 11
EC - Ecuador 10
JM - Giamaica 10
LT - Lituania 10
PK - Pakistan 9
CO - Colombia 8
UZ - Uzbekistan 8
VE - Venezuela 8
AE - Emirati Arabi Uniti 7
CR - Costa Rica 7
HN - Honduras 7
MA - Marocco 7
TH - Thailandia 7
AZ - Azerbaigian 6
UY - Uruguay 6
EU - Europa 5
IL - Israele 5
KE - Kenya 5
MY - Malesia 5
NI - Nicaragua 5
PH - Filippine 5
DZ - Algeria 4
EG - Egitto 4
PE - Perù 4
RO - Romania 4
TN - Tunisia 4
TW - Taiwan 4
CI - Costa d'Avorio 3
DK - Danimarca 3
JO - Giordania 3
MD - Moldavia 3
PR - Porto Rico 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
BB - Barbados 2
BG - Bulgaria 2
CH - Svizzera 2
ET - Etiopia 2
GA - Gabon 2
GP - Guadalupe 2
GR - Grecia 2
GT - Guatemala 2
HU - Ungheria 2
NP - Nepal 2
PA - Panama 2
PT - Portogallo 2
PY - Paraguay 2
SV - El Salvador 2
TT - Trinidad e Tobago 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AU - Australia 1
AW - Aruba 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CG - Congo 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
DO - Repubblica Dominicana 1
KG - Kirghizistan 1
KH - Cambogia 1
Totale 9.685
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Città #
Dublin 571
San Jose 367
Jacksonville 333
Hong Kong 253
Singapore 249
Ashburn 226
Dearborn 190
Council Bluffs 178
Beijing 155
Chandler 118
Munich 109
Los Angeles 107
Ann Arbor 104
Piemonte 88
Columbus 81
Moscow 78
New York 77
Wilmington 71
Lauterbourg 64
Lawrence 64
Princeton 64
San Mateo 63
Hanoi 61
Novara 61
Phoenix 58
Santa Clara 55
Dallas 53
Ho Chi Minh City 53
Helsinki 49
Bremen 40
Milan 38
Buffalo 35
Frankfurt am Main 33
Andover 32
Turku 31
Denver 27
Turin 27
São Paulo 26
Ankara 25
Montreal 25
Chicago 24
Brussels 22
Hefei 22
Orem 22
Atlanta 21
Toronto 21
Chennai 20
Houston 20
London 20
Warsaw 19
Brooklyn 18
Vercelli 18
Cotonou 17
Seoul 16
Tokyo 16
Tornaco 16
Redondo Beach 15
Boston 14
Brno 14
Da Nang 14
Falkenstein 14
Rome 14
Zola Predosa 14
Poplar 13
The Dalles 13
Tianjin 13
Boardman 12
Kocaeli 12
Manchester 12
Seattle 12
Stockholm 12
Mexico City 11
Norwalk 11
Woodbridge 11
Amsterdam 10
Ardabil 10
Guangzhou 10
Hillsboro 10
Johannesburg 10
Monmouth Junction 10
Nanjing 10
San Francisco 10
Fairfield 9
Kingston 9
Treviso 9
Reggio Emilia 8
Tashkent 8
Bari 7
Berlin 7
Bexley 7
Brasília 7
Calvisano 7
Charlotte 7
Cleveland 7
Jakarta 7
Jinan 7
Kunming 7
Nuremberg 7
Rio de Janeiro 7
San José 7
Totale 5.096
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Nome #
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 347
Deuterium in drug discovery: progress, opportunities and challenges 209
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 193
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 183
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 183
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 176
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 173
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 171
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 165
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 161
Applications of deuterium in medicinal chemistry 159
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 157
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 157
A primer of deuterium in drug design 152
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 148
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 148
Essential Medicinal Chemistry of Essential Medicines 145
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 144
Estrogenic analogues synthesized by click chemistry 143
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 142
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 140
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 140
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 138
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 138
A concise entry into nonsymmetrical alkyl polyamines 135
TRPV1 Modulator Compounds 134
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 133
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 132
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 132
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 132
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 131
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 130
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 127
An aryne-based three-component access to α-aroylamino amides 126
A Concise Entry into Nonsymmetrical Alkyl Polyamines 125
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 123
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 122
Transition-Metal-Free Direct Arylation of Anilines 122
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 122
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 122
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 121
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 118
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 117
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 117
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 117
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 117
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 117
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 116
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 116
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 115
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 114
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 111
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 110
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 108
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 107
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 107
PI3K keeps the balance between metabolism and cancer 106
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 106
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 105
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 104
Soft drugs for dermatological applications: recent trends 104
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 101
Synthesis and biological evaluation of combretatriazoles 98
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 97
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 92
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 89
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 86
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 82
Synthesis and biological evaluation of combretatriazoles 82
Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis 80
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 77
Medicinal chemistry of combretastatin A4: present and future directions 77
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 76
Moonlighting Proteins Are Important Players in Cancer Immunology 75
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 72
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 67
Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery 61
Sustainable Photocatalytic Synthesis of Glitazones via Riboflavin Tetraacetate 38
Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling 35
Deuterated active pharmaceutical ingredients 27
Preparation of biphenyl amides as dual-targeting SOCE/DHODH inhibitors 22
Totale 9.847
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Categoria #
all - tutte 44.438
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.438
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022429 0 0 0 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.199 29 39 73 60 53 116 122 111 188 76 66 266
2025/20263.479 227 114 223 469 339 221 430 569 231 364 199 93
2026/20271.267 373 329 273 292 0 0 0 0 0 0 0 0
Totale 9.847