IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 3.339
NA - Nord America 2.622
AS - Asia 1.854
SA - Sud America 253
AF - Africa 65
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 1
Totale 8.140
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Nazione #
US - Stati Uniti d'America 2.539
RU - Federazione Russa 744
IE - Irlanda 570
SG - Singapore 533
IT - Italia 532
CN - Cina 444
DE - Germania 437
SE - Svezia 312
VN - Vietnam 248
HK - Hong Kong 247
UA - Ucraina 187
BR - Brasile 178
FI - Finlandia 150
FR - Francia 124
GB - Regno Unito 119
IN - India 115
TR - Turchia 69
CA - Canada 50
AR - Argentina 30
EE - Estonia 27
IR - Iran 26
JP - Giappone 23
PL - Polonia 23
BE - Belgio 21
KR - Corea 21
BD - Bangladesh 20
MX - Messico 20
ES - Italia 18
BJ - Benin 17
NL - Olanda 17
ZA - Sudafrica 15
CZ - Repubblica Ceca 14
ID - Indonesia 14
AT - Austria 13
SA - Arabia Saudita 13
IQ - Iraq 12
CL - Cile 11
EC - Ecuador 10
LT - Lituania 10
PK - Pakistan 10
UZ - Uzbekistan 9
VE - Venezuela 8
MA - Marocco 7
AE - Emirati Arabi Uniti 6
AZ - Azerbaigian 6
TH - Thailandia 6
UY - Uruguay 6
EU - Europa 5
IL - Israele 5
KE - Kenya 5
PH - Filippine 5
CO - Colombia 4
DZ - Algeria 4
RO - Romania 4
TN - Tunisia 4
TW - Taiwan 4
CI - Costa d'Avorio 3
EG - Egitto 3
JM - Giamaica 3
JO - Giordania 3
PE - Perù 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
BG - Bulgaria 2
CH - Svizzera 2
ET - Etiopia 2
GA - Gabon 2
HN - Honduras 2
HU - Ungheria 2
NP - Nepal 2
PA - Panama 2
PY - Paraguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
GR - Grecia 1
GT - Guatemala 1
KG - Kirghizistan 1
KH - Cambogia 1
KZ - Kazakistan 1
LB - Libano 1
LV - Lettonia 1
MD - Moldavia 1
MM - Myanmar 1
MY - Malesia 1
NG - Nigeria 1
OM - Oman 1
RS - Serbia 1
SI - Slovenia 1
SV - El Salvador 1
Totale 8.138
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Città #
Dublin 570
Jacksonville 329
Singapore 243
Hong Kong 241
San Jose 213
Dearborn 190
Ashburn 181
Beijing 150
Chandler 118
Munich 112
Ann Arbor 104
Piemonte 88
Los Angeles 83
Moscow 79
Wilmington 70
Novara 67
Lauterbourg 64
Lawrence 64
Princeton 64
Hanoi 63
San Mateo 63
Ho Chi Minh City 55
New York 50
Helsinki 49
Bremen 40
Buffalo 33
Frankfurt am Main 33
Andover 32
Turku 32
Milan 31
Dallas 29
Ankara 25
Santa Clara 25
São Paulo 25
Turin 25
Montreal 23
Hefei 22
Chennai 20
London 20
Orem 20
Brussels 19
Vercelli 19
Warsaw 18
Cotonou 17
Houston 16
Seoul 16
Redondo Beach 15
Brno 14
Da Nang 14
Falkenstein 14
Tokyo 14
Zola Predosa 14
Council Bluffs 13
Phoenix 13
Poplar 13
Boardman 12
Kocaeli 12
Tianjin 12
Toronto 12
Atlanta 11
Chicago 11
Hillsboro 11
Norwalk 11
Seattle 11
Stockholm 11
Amsterdam 10
Ardabil 10
Brooklyn 10
Denver 10
Guangzhou 10
Johannesburg 10
Manchester 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Mexico City 9
Tashkent 9
Treviso 9
Fairfield 8
Berlin 7
Bexley 7
Calvisano 7
Jakarta 7
Jinan 7
Nuremberg 7
Reggio Emilia 7
Torino 7
Baghdad 6
Baku 6
Chengdu 6
Imola 6
Kunming 6
Nanchang 6
Rio de Janeiro 6
Roubaix 6
San Francisco 6
Asti 5
Boston 5
Can Tho 5
Leawood 5
Totale 4.353
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Nome #
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 178
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 170
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 165
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 158
Deuterium in drug discovery: progress, opportunities and challenges 155
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 153
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 151
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 149
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 146
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 138
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 133
A primer of deuterium in drug design 132
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 131
Applications of deuterium in medicinal chemistry 131
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 129
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 129
Estrogenic analogues synthesized by click chemistry 127
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 127
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 125
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 125
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 125
TRPV1 Modulator Compounds 123
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 122
A concise entry into nonsymmetrical alkyl polyamines 119
An aryne-based three-component access to α-aroylamino amides 119
Essential Medicinal Chemistry of Essential Medicines 119
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 118
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 118
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 117
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 116
Transition-Metal-Free Direct Arylation of Anilines 116
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 116
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 115
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 112
A Concise Entry into Nonsymmetrical Alkyl Polyamines 111
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 110
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 109
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 105
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 104
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 103
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 102
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 101
null 100
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 98
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 98
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 98
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 98
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 96
PI3K keeps the balance between metabolism and cancer 96
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 96
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 95
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 94
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 94
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 93
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 93
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 92
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 92
Soft drugs for dermatological applications: recent trends 92
Synthesis and biological evaluation of combretatriazoles 90
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 89
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 87
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 85
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 83
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 79
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 77
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 75
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 73
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 73
Synthesis and biological evaluation of combretatriazoles 73
Medicinal chemistry of combretastatin A4: present and future directions 69
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 68
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 68
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 65
Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis 57
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 56
Moonlighting Proteins Are Important Players in Cancer Immunology 55
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 37
Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery 27
Sustainable Photocatalytic Synthesis of Glitazones via Riboflavin Tetraacetate 24
Totale 8.287
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Categoria #
all - tutte 36.298
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.298
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021116 0 0 0 0 0 0 0 0 0 36 65 15
2021/2022559 34 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.217 29 39 73 60 53 116 122 119 192 78 66 270
2025/20263.168 233 117 229 473 347 224 440 576 236 293 0 0
Totale 8.287