IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 1.920
NA - Nord America 1.590
AS - Asia 642
Continente sconosciuto - Info sul continente non disponibili 6
AF - Africa 2
SA - Sud America 2
Totale 4.162
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Nazione #
US - Stati Uniti d'America 1.577
IE - Irlanda 568
IT - Italia 366
SE - Svezia 302
DE - Germania 288
UA - Ucraina 174
HK - Hong Kong 162
SG - Singapore 150
CN - Cina 149
FI - Finlandia 99
IN - India 80
TR - Turchia 55
GB - Regno Unito 53
IR - Iran 25
BE - Belgio 18
CZ - Repubblica Ceca 14
CA - Canada 13
FR - Francia 9
AT - Austria 7
JP - Giappone 7
EU - Europa 5
RU - Federazione Russa 5
VN - Vietnam 5
NL - Olanda 4
IL - Israele 3
LT - Lituania 3
ES - Italia 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BG - Bulgaria 1
CH - Svizzera 1
CL - Cile 1
EG - Egitto 1
HU - Ungheria 1
IQ - Iraq 1
JO - Giordania 1
KR - Corea 1
LV - Lettonia 1
MA - Marocco 1
PE - Perù 1
UZ - Uzbekistan 1
Totale 4.162
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Città #
Dublin 568
Jacksonville 327
Dearborn 190
Hong Kong 161
Chandler 118
Singapore 115
Ann Arbor 104
Piemonte 88
Wilmington 69
Lawrence 64
Princeton 64
San Mateo 63
Beijing 50
Bremen 40
Andover 32
Ashburn 30
Helsinki 30
Munich 25
Hefei 22
Ankara 21
Novara 20
Turin 19
Brussels 18
Vercelli 16
Brno 14
Zola Predosa 14
Milan 13
Dallas 12
Kocaeli 12
Santa Clara 12
Boardman 11
Norwalk 11
Ardabil 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Toronto 9
Fairfield 8
London 8
Seattle 8
Berlin 7
Calvisano 7
Jinan 7
Torino 7
Imola 6
Kunming 6
Nanchang 6
Asti 5
Frankfurt am Main 5
Houston 5
Leawood 5
Mülheim 5
Noicattaro 5
Shenyang 5
Trieste 5
Bari 4
Biella 4
Cassano Magnago 4
Cerano 4
Dong Ket 4
Oggiono 4
Zanjan 4
Ashdod 3
Augusta 3
Barzago 3
Busto Arsizio 3
Chengdu 3
Chongqing 3
Espoo 3
Grafing 3
Ipswich 3
Kecioeren 3
Nonantola 3
Rankweil 3
Vienna 3
Wenzhou 3
Bratislava 2
Cambridge 2
Cameriano 2
Como 2
Des Moines 2
Falkenstein 2
Genova 2
Grignasco 2
Guangzhou 2
Gunzenhausen 2
Hebei 2
Los Angeles 2
Madrid 2
Moncalieri 2
Napoli 2
New York 2
Nijmegen 2
Ottawa 2
Rho 2
Sacramento 2
San Giuliano Milanese 2
Shanghai 2
Stockholm 2
Vergiate 2
Totale 2.630
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Nome #
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 103
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 101
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 96
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 88
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 86
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 86
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 86
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 84
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 82
Transition-Metal-Free Direct Arylation of Anilines 81
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 80
A primer of deuterium in drug design 80
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 79
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 78
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 75
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 74
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 74
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 74
Applications of deuterium in medicinal chemistry 72
The Essential Medicinal Chemistry of Essential Medicines 72
A concise entry into nonsymmetrical alkyl polyamines 71
An aryne-based three-component access to α-aroylamino amides 70
TRPV1 Modulator Compounds 70
PI3K keeps the balance between metabolism and cancer 68
Estrogenic analogues synthesized by click chemistry 68
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 68
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 66
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 66
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 65
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 65
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 63
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 61
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 61
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 60
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 60
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 59
A Concise Entry into Nonsymmetrical Alkyl Polyamines 59
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 57
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 57
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 57
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 56
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 54
Soft drugs for dermatological applications: recent trends 54
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 53
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 53
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 53
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 51
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 50
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 50
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 49
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 48
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 48
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 48
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 47
Synthesis and biological evaluation of combretatriazoles 47
Medicinal chemistry of combretastatin A4: present and future directions 46
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 45
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 44
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 44
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 43
Synthesis and biological evaluation of combretatriazoles 41
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 40
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 38
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 37
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 36
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 36
Moonlighting Proteins Are Important Players in Cancer Immunology 32
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 31
Deuterium in drug discovery: progress, opportunities and challenges 24
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 19
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 19
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 19
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 13
Totale 4.290
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Categoria #
all - tutte 23.220
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.220
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020477 0 0 0 0 0 0 176 35 63 98 94 11
2020/2021515 67 2 58 5 61 33 69 22 82 36 65 15
2021/2022559 34 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/2025388 29 39 73 60 53 116 18 0 0 0 0 0
Totale 4.290