IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 3.377
NA - Nord America 3.215
AS - Asia 1.945
SA - Sud America 254
Continente sconosciuto - Info sul continente non disponibili 157
AF - Africa 66
OC - Oceania 1
Totale 9.015
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Nazione #
US - Stati Uniti d'America 3.112
RU - Federazione Russa 737
SG - Singapore 572
IE - Irlanda 571
IT - Italia 566
CN - Cina 475
DE - Germania 436
SE - Svezia 313
HK - Hong Kong 255
VN - Vietnam 243
UA - Ucraina 187
BR - Brasile 180
FI - Finlandia 149
FR - Francia 122
GB - Regno Unito 122
IN - India 117
TR - Turchia 69
CA - Canada 63
BD - Bangladesh 32
AR - Argentina 30
IR - Iran 26
EE - Estonia 25
JP - Giappone 24
PL - Polonia 24
KR - Corea 23
BE - Belgio 21
MX - Messico 21
ES - Italia 20
NL - Olanda 18
BJ - Benin 17
CZ - Repubblica Ceca 17
ZA - Sudafrica 15
AT - Austria 13
ID - Indonesia 13
SA - Arabia Saudita 13
IQ - Iraq 12
CL - Cile 11
LT - Lituania 10
PK - Pakistan 9
EC - Ecuador 8
UZ - Uzbekistan 8
VE - Venezuela 8
AE - Emirati Arabi Uniti 7
MA - Marocco 7
TH - Thailandia 7
AZ - Azerbaigian 6
UY - Uruguay 6
CO - Colombia 5
EU - Europa 5
IL - Israele 5
JM - Giamaica 5
KE - Kenya 5
PH - Filippine 5
DZ - Algeria 4
EG - Egitto 4
RO - Romania 4
TN - Tunisia 4
TW - Taiwan 4
CI - Costa d'Avorio 3
HN - Honduras 3
JO - Giordania 3
MD - Moldavia 3
MY - Malesia 3
PE - Perù 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
BG - Bulgaria 2
CH - Svizzera 2
CR - Costa Rica 2
ET - Etiopia 2
GA - Gabon 2
GR - Grecia 2
HU - Ungheria 2
NP - Nepal 2
PA - Panama 2
PT - Portogallo 2
PY - Paraguay 2
TT - Trinidad e Tobago 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
GP - Guadalupe 1
GT - Guatemala 1
KG - Kirghizistan 1
KH - Cambogia 1
KZ - Kazakistan 1
LB - Libano 1
LV - Lettonia 1
MM - Myanmar 1
NG - Nigeria 1
NI - Nicaragua 1
Totale 8.860
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Città #
Dublin 570
Jacksonville 329
San Jose 270
Hong Kong 249
Singapore 247
Ashburn 211
Dearborn 190
Beijing 154
Chandler 118
Munich 109
Ann Arbor 104
Los Angeles 99
Council Bluffs 97
Piemonte 88
Moscow 78
New York 71
Wilmington 71
Lauterbourg 64
Lawrence 64
Princeton 64
San Mateo 63
Hanoi 61
Novara 61
Ho Chi Minh City 53
Dallas 50
Helsinki 49
Santa Clara 45
Bremen 40
Frankfurt am Main 33
Andover 32
Buffalo 32
Milan 32
Turku 31
Ankara 25
São Paulo 25
Turin 25
Montreal 24
Hefei 22
Orem 22
Chennai 20
London 20
Brussels 19
Houston 19
Phoenix 19
Warsaw 19
Toronto 18
Vercelli 18
Chicago 17
Cotonou 17
Atlanta 16
Denver 16
Seoul 16
Tornaco 16
Brooklyn 15
Redondo Beach 15
Brno 14
Da Nang 14
Falkenstein 14
Tokyo 14
Zola Predosa 14
Poplar 13
The Dalles 13
Tianjin 13
Boardman 12
Kocaeli 12
Stockholm 12
Manchester 11
Norwalk 11
Seattle 11
Amsterdam 10
Ardabil 10
Boston 10
Guangzhou 10
Hillsboro 10
Johannesburg 10
Mexico City 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Rome 9
San Francisco 9
Treviso 9
Fairfield 8
Tashkent 8
Berlin 7
Bexley 7
Calvisano 7
Jakarta 7
Jinan 7
Kunming 7
Nuremberg 7
Reggio Emilia 7
Torino 7
Baghdad 6
Baku 6
Cambridge 6
Chengdu 6
Imola 6
Madrid 6
Nanchang 6
Totale 4.678
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Nome #
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 332
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 181
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 174
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 170
Deuterium in drug discovery: progress, opportunities and challenges 167
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 167
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 162
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 161
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 160
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 153
Applications of deuterium in medicinal chemistry 150
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 148
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 145
A primer of deuterium in drug design 138
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 137
Estrogenic analogues synthesized by click chemistry 135
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 133
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 133
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 133
Essential Medicinal Chemistry of Essential Medicines 133
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 132
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 132
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 129
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 128
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 125
TRPV1 Modulator Compounds 125
A concise entry into nonsymmetrical alkyl polyamines 124
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 123
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 123
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 121
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 121
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 121
An aryne-based three-component access to α-aroylamino amides 121
Transition-Metal-Free Direct Arylation of Anilines 118
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 118
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 117
A Concise Entry into Nonsymmetrical Alkyl Polyamines 114
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 113
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 112
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 111
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 111
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 110
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 109
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 108
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 108
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 108
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 108
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 105
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 105
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 105
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 103
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 103
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 101
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 100
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 99
PI3K keeps the balance between metabolism and cancer 98
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 98
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 97
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 97
Soft drugs for dermatological applications: recent trends 96
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 94
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 93
Synthesis and biological evaluation of combretatriazoles 92
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 90
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 81
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 80
Synthesis and biological evaluation of combretatriazoles 78
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 75
Medicinal chemistry of combretastatin A4: present and future directions 73
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 73
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 70
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 69
Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis 67
Moonlighting Proteins Are Important Players in Cancer Immunology 62
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 58
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 58
Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery 44
Sustainable Photocatalytic Synthesis of Glitazones via Riboflavin Tetraacetate 32
Preparation of biphenyl amides as dual-targeting SOCE/DHODH inhibitors 10
Deuterated active pharmaceutical ingredients 7
Totale 9.015
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Categoria #
all - tutte 40.795
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.795
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022525 0 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.199 29 39 73 60 53 116 122 111 188 76 66 266
2025/20263.479 227 114 223 469 339 221 430 569 231 364 199 93
2026/2027435 373 62 0 0 0 0 0 0 0 0 0 0
Totale 9.015