IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 2.312
NA - Nord America 1.723
AS - Asia 848
SA - Sud America 46
AF - Africa 10
Continente sconosciuto - Info sul continente non disponibili 6
Totale 4.945
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Nazione #
US - Stati Uniti d'America 1.696
IE - Irlanda 568
IT - Italia 462
DE - Germania 366
SE - Svezia 303
SG - Singapore 259
HK - Hong Kong 217
UA - Ucraina 183
CN - Cina 158
FI - Finlandia 131
RU - Federazione Russa 128
IN - India 81
GB - Regno Unito 62
TR - Turchia 60
BR - Brasile 41
EE - Estonia 27
IR - Iran 25
CA - Canada 22
BE - Belgio 19
CZ - Repubblica Ceca 14
FR - Francia 12
AT - Austria 11
ID - Indonesia 10
NL - Olanda 8
JP - Giappone 7
LT - Lituania 6
VN - Vietnam 6
EU - Europa 5
UZ - Uzbekistan 5
SA - Arabia Saudita 4
IL - Israele 3
IQ - Iraq 3
MA - Marocco 3
MX - Messico 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
BD - Bangladesh 2
CH - Svizzera 2
EG - Egitto 2
ES - Italia 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
VE - Venezuela 2
ZA - Sudafrica 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
BG - Bulgaria 1
CL - Cile 1
DZ - Algeria 1
GT - Guatemala 1
HU - Ungheria 1
JO - Giordania 1
KE - Kenya 1
KR - Corea 1
LV - Lettonia 1
NP - Nepal 1
PE - Perù 1
TH - Thailandia 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
UY - Uruguay 1
Totale 4.945
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Città #
Dublin 568
Jacksonville 328
Hong Kong 216
Dearborn 190
Singapore 132
Chandler 118
Ann Arbor 104
Piemonte 88
Munich 74
Wilmington 69
Novara 66
Lawrence 64
Princeton 64
San Mateo 63
Beijing 55
Moscow 49
Helsinki 41
Bremen 40
Ashburn 38
Andover 32
Milan 25
Ankara 23
Hefei 22
Turin 21
Turku 21
Brussels 19
Vercelli 16
Brno 14
Santa Clara 14
Zola Predosa 14
Falkenstein 13
Dallas 12
Kocaeli 12
Boardman 11
Norwalk 11
Toronto 11
Ardabil 10
London 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Fairfield 8
Seattle 8
Berlin 7
Calvisano 7
Jakarta 7
Jinan 7
Reggio Emilia 7
Torino 7
Imola 6
Kunming 6
Los Angeles 6
Nanchang 6
Asti 5
Frankfurt am Main 5
Houston 5
Leawood 5
Mülheim 5
Noicattaro 5
Nuremberg 5
Shenyang 5
Tashkent 5
Trieste 5
Bari 4
Biella 4
Cassano Magnago 4
Cerano 4
Dong Ket 4
Oggiono 4
São Paulo 4
Vienna 4
Zanjan 4
Amsterdam 3
Ashdod 3
Augusta 3
Barzago 3
Boydton 3
Busto Arsizio 3
Carmagnola 3
Chengdu 3
Chongqing 3
Espoo 3
Grafing 3
Ipswich 3
Kecioeren 3
New York 3
Nonantola 3
Olivet 3
Osimo 3
Rankweil 3
San Francisco 3
Stockholm 3
Wenzhou 3
Baghdad 2
Baku 2
Betim 2
Brasília 2
Bratislava 2
Cambridge 2
Cameriano 2
Totale 2.953
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Nome #
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 111
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 110
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 105
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 104
null 100
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 96
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 95
Transition-Metal-Free Direct Arylation of Anilines 94
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 93
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 93
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 91
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 90
A primer of deuterium in drug design 90
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 88
Essential Medicinal Chemistry of Essential Medicines 88
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 85
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 84
Applications of deuterium in medicinal chemistry 84
Estrogenic analogues synthesized by click chemistry 82
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 82
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 82
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 81
TRPV1 Modulator Compounds 81
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 80
An aryne-based three-component access to α-aroylamino amides 79
A concise entry into nonsymmetrical alkyl polyamines 77
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 77
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 76
PI3K keeps the balance between metabolism and cancer 75
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 75
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 74
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 73
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 72
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 72
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 71
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 69
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 68
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 67
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 67
A Concise Entry into Nonsymmetrical Alkyl Polyamines 66
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 66
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 65
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 65
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 64
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 63
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 60
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 60
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 59
Soft drugs for dermatological applications: recent trends 59
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 58
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 57
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 57
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 56
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 55
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 54
Deuterium in drug discovery: progress, opportunities and challenges 53
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 53
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 53
Synthesis and biological evaluation of combretatriazoles 53
Synthesis and biological evaluation of combretatriazoles 52
Medicinal chemistry of combretastatin A4: present and future directions 50
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 49
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 49
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 48
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 46
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 45
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 40
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 40
Moonlighting Proteins Are Important Players in Cancer Immunology 40
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 37
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 32
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 31
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 29
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 25
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 18
Totale 5.088
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Categoria #
all - tutte 27.670
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.670
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202011 0 0 0 0 0 0 0 0 0 0 0 11
2020/2021515 67 2 58 5 61 33 69 22 82 36 65 15
2021/2022559 34 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.186 29 39 73 60 53 116 122 119 192 78 66 239
Totale 5.088