IRIS
PIRALI, Tracey
 Distribuzione geografica
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Continente #
EU - Europa 3.380
NA - Nord America 3.379
AS - Asia 1.951
SA - Sud America 257
Continente sconosciuto - Info sul continente non disponibili 157
AF - Africa 66
OC - Oceania 1
Totale 9.191
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Nazione #
US - Stati Uniti d'America 3.274
RU - Federazione Russa 737
SG - Singapore 574
IE - Irlanda 571
IT - Italia 569
CN - Cina 477
DE - Germania 436
SE - Svezia 313
HK - Hong Kong 256
VN - Vietnam 243
UA - Ucraina 187
BR - Brasile 181
FI - Finlandia 149
FR - Francia 122
GB - Regno Unito 122
IN - India 117
TR - Turchia 69
CA - Canada 63
BD - Bangladesh 32
AR - Argentina 31
IR - Iran 26
EE - Estonia 25
JP - Giappone 24
PL - Polonia 24
KR - Corea 23
BE - Belgio 21
MX - Messico 21
ES - Italia 20
NL - Olanda 18
BJ - Benin 17
CZ - Repubblica Ceca 17
ZA - Sudafrica 15
ID - Indonesia 14
AT - Austria 13
SA - Arabia Saudita 13
IQ - Iraq 12
CL - Cile 11
LT - Lituania 10
PK - Pakistan 9
EC - Ecuador 8
UZ - Uzbekistan 8
VE - Venezuela 8
AE - Emirati Arabi Uniti 7
MA - Marocco 7
TH - Thailandia 7
AZ - Azerbaigian 6
CO - Colombia 6
UY - Uruguay 6
EU - Europa 5
IL - Israele 5
JM - Giamaica 5
KE - Kenya 5
PH - Filippine 5
DZ - Algeria 4
EG - Egitto 4
HN - Honduras 4
RO - Romania 4
TN - Tunisia 4
TW - Taiwan 4
CI - Costa d'Avorio 3
JO - Giordania 3
MD - Moldavia 3
MY - Malesia 3
PE - Perù 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
BG - Bulgaria 2
CH - Svizzera 2
CR - Costa Rica 2
ET - Etiopia 2
GA - Gabon 2
GR - Grecia 2
HU - Ungheria 2
NP - Nepal 2
PA - Panama 2
PT - Portogallo 2
PY - Paraguay 2
TT - Trinidad e Tobago 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CD - Congo 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
GP - Guadalupe 1
GT - Guatemala 1
KG - Kirghizistan 1
KH - Cambogia 1
KZ - Kazakistan 1
LB - Libano 1
LV - Lettonia 1
MM - Myanmar 1
NG - Nigeria 1
NI - Nicaragua 1
Totale 9.035
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Città #
Dublin 570
Jacksonville 329
San Jose 270
Hong Kong 250
Singapore 249
Ashburn 213
Dearborn 190
Council Bluffs 161
Beijing 155
Chandler 118
Munich 109
Ann Arbor 104
Los Angeles 99
Piemonte 88
Columbus 81
Moscow 78
New York 71
Wilmington 71
Lauterbourg 64
Lawrence 64
Princeton 64
San Mateo 63
Hanoi 61
Novara 61
Ho Chi Minh City 53
Dallas 50
Helsinki 49
Santa Clara 47
Bremen 40
Frankfurt am Main 33
Andover 32
Buffalo 32
Milan 32
Turku 31
Ankara 25
São Paulo 25
Turin 25
Montreal 24
Hefei 22
Orem 22
Phoenix 22
Chennai 20
London 20
Brussels 19
Houston 19
Warsaw 19
Toronto 18
Vercelli 18
Chicago 17
Cotonou 17
Atlanta 16
Denver 16
Seoul 16
Tornaco 16
Brooklyn 15
Redondo Beach 15
Brno 14
Da Nang 14
Falkenstein 14
Tokyo 14
Zola Predosa 14
Poplar 13
The Dalles 13
Tianjin 13
Boardman 12
Kocaeli 12
Stockholm 12
Manchester 11
Norwalk 11
Seattle 11
Amsterdam 10
Ardabil 10
Boston 10
Guangzhou 10
Hillsboro 10
Johannesburg 10
Mexico City 10
Monmouth Junction 10
Nanjing 10
Woodbridge 10
Rome 9
San Francisco 9
Treviso 9
Fairfield 8
Reggio Emilia 8
Tashkent 8
Berlin 7
Bexley 7
Calvisano 7
Jakarta 7
Jinan 7
Kunming 7
Nuremberg 7
Torino 7
Baghdad 6
Baku 6
Cambridge 6
Chengdu 6
Imola 6
Madrid 6
Totale 4.829
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Nome #
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? 335
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy. 182
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells 175
Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders 173
Deuterium in drug discovery: progress, opportunities and challenges 170
Preparation of 1-​(triazolylphenyl)​-​5-​(trifluoromethyl)​pyrazole compounds useful as SOCE modulators 169
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis 164
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction 164
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents 162
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies 155
Applications of deuterium in medicinal chemistry 152
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs 150
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors 148
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs 140
A primer of deuterium in drug design 140
Estrogenic analogues synthesized by click chemistry 136
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors 136
Synthesis, biological evaluation and molecular docking of Ugi and Passerini products as novel indoleamine 2,3-dioxygenase 1 inhibitors 135
Essential Medicinal Chemistry of Essential Medicines 135
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability 135
A novel alpha-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 134
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides 134
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues 131
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry 130
A concise entry into nonsymmetrical alkyl polyamines 127
Quinolin-4 (1h) -one derivatives as inhibitors of phosphatidylinositol 3-kinases 127
TRPV1 Modulator Compounds 127
Arynes and isocyanides: Two close-knit partners in multicomponent reactions 125
Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions 125
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy 123
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes 123
An aryne-based three-component access to α-aroylamino amides 123
A practical synthesis of 5-aroyl-1-aryltetrazoles using an Ugi-like 4-component reaction followed by a biomimetic transamination 122
Transition-Metal-Free Direct Arylation of Anilines 120
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors 120
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA 119
A Concise Entry into Nonsymmetrical Alkyl Polyamines 117
A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction 115
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors 114
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors 114
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1 113
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates 112
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation 112
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry 111
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery 111
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis 111
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications 110
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity 110
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications 109
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides 107
Ammonium Chloride Promoted Three-Component Synthesis of 5-Iminooxazoline and its Subsequent Transformation to Macrocyclodepsipeptide 106
The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators 105
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylase 101
Solution-phase parallel synthesis and biological evaluation of combretatriazoles 101
Synthesis, molecular docking and biological evalutation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition 101
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 100
PI3K keeps the balance between metabolism and cancer 100
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents 100
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline 99
Soft drugs for dermatological applications: recent trends 98
Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents 97
Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides 96
Synthesis and biological evaluation of combretatriazoles 94
Synthesis of Passerini-Ugi hybrids by a four-component reaction using the glycolaldehyde dimer 92
First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy 83
One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] 82
Synthesis and biological evaluation of combretatriazoles 80
Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins 78
Medicinal chemistry of combretastatin A4: present and future directions 75
Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones 75
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids 72
Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis 70
In search of novel antitubulin agents: synthesis of 1-aryl-5-aroyl tetrazoles by an Ugi 4-CR/hydrogenolysis/transamination reaction 70
Moonlighting Proteins Are Important Players in Cancer Immunology 64
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry 62
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy 59
Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery 46
Sustainable Photocatalytic Synthesis of Glitazones via Riboflavin Tetraacetate 33
Preparation of biphenyl amides as dual-targeting SOCE/DHODH inhibitors 12
Deuterated active pharmaceutical ingredients 8
Totale 9.191
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Categoria #
all - tutte 41.210
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.210
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022525 0 32 64 81 22 7 40 10 25 56 63 125
2022/20231.292 77 58 83 31 94 111 62 73 609 15 53 26
2023/2024384 33 39 40 12 58 3 85 13 6 2 30 63
2024/20251.199 29 39 73 60 53 116 122 111 188 76 66 266
2025/20263.479 227 114 223 469 339 221 430 569 231 364 199 93
2026/2027611 373 238 0 0 0 0 0 0 0 0 0 0
Totale 9.191