SERAFINI, MARTA
SERAFINI, MARTA
Dipartimento di Scienze del Farmaco
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry
2021-01-01 Aprile, Silvio; Riva, Beatrice; Bhela, Irene Preet; Cordero-Sanchez, Celia; Avino, Giulia; Genazzani, Armando; Serafini, Marta; Pirali, Tracey
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability
2021-01-01 Nikolaeva-Koleva, M.; Butron, L.; Gonzalez-Rodriguez, S.; Devesa, I.; Valente, P.; Serafini, M.; Genazzani, A.; Pirali, T.; Ballester, G. F.; Fernandez-Carvajal, A.; Ferrer-Montiel, A.
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies
2018-01-01 Griglio, Alessia; Torre, Enza; Serafini, Marta; Bianchi, Alice; Schmid, Roberta; CODA ZABETTA, Giulia; Massarotti, Alberto; Sorba, Giovanni; Pirali, Tracey; Fallarini, Silvia
A primer of deuterium in drug design
2019-01-01 Cargnin, Sarah; Serafini, Marta; Pirali, Tracey
A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs
2022-01-01 Bhela, Irene Preet; Ranza, Alice; Balestrero, Federica Carolina; Serafini, Marta; Aprile, Silvio; Di Martino, Rita Maria Concetta; Condorelli, Fabrizio; Pirali, Tracey
An aryne-based three-component access to α-aroylamino amides
2017-01-01 Serafini, Marta; Griglio, Alessia; Viarengo, Sara; Aprile, Silvio; Pirali, Tracey
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
2022-01-01 Aprile, Silvio; Colombo, Giorgia; Serafini, Marta; Di Paola, Rosanna; Pisati, Federica; Bhela, Irene Preet; Cuzzocrea, Salvatore; Grosa, Giorgio; Pirali, Tracey
Applications of deuterium in medicinal chemistry
2019-01-01 Pirali, Tracey; Serafini, Marta; Cargnin, Sarah; Genazzani, Armando
Arynes and isocyanides: Two close-knit partners in multicomponent reactions
2018-01-01 Serafini, Marta; Pirali, Tracey
CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy
2022-01-01 Cordero-Sanchez, Celia; Pessolano, Emanuela; Riva, Beatrice; Vismara, Mauro; Trivigno, Silvia Maria Grazia; Clemente, Nausicaa; Aprile, Silvio; Ruffinatti, Federico Alessandro; Portararo, Paola; Filigheddu, Nicoletta; Zaggia, Ivan; Bhela, Irene P; Serafini, Marta; Pirali, Tracey; Colombo, Mario P; Torti, Mauro; Sangaletti, Sabina; Bertoni, Alessandra; Genazzani, Armando
Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic?
2020-01-01 Serafini, M.; Pirali, T.; Tron, G. C.
Discovery and development of small molecules targeting IDO1 and SOCE
2021-01-01 Serafini, Marta
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity
2020-01-01 Serafini, M.; Torre, E.; Aprile, S.; Del Grosso, E.; Gesu, A.; Griglio, A.; Colombo, G.; Travelli, C.; Paiella, S.; Adamo, A.; Orecchini, E.; Coletti, A.; Pallotta, M. T.; Ugel, S.; Massarotti, A.; Pirali, T.; Fallarini, S.
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction
2019-01-01 Pirali, Tracey; Galli, Ubaldina; Serafini, Marta; Griglio, Alessia; Genazzani, Armando; Tron, Gian Cesare
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
2017-01-01 Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis
2018-01-01 Riva, Beatrice; Griglio, Alessia; Serafini, Marta; CORDERO SANCHEZ, Celia; Aprile, Silvio; Di Paola, Rosanna; Gugliandolo, Enrico; Alansary, Dalia; Biocotino, Isabella; Lim, Dmitry; Grosa, Giorgio; Galli, Ubaldina; Niemeyer, Barbara; Sorba, Giovanni; Canonico, Pier Luigi; Cuzzocrea, Salvatore; Genazzani, Armando; Pirali, Tracey
SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA
2019-01-01 Serafini, Marta; Pirali, Tracey
Soft drugs for dermatological applications: recent trends
2019-01-01 Aprile, Silvio; Serafini, Marta; Pirali, Tracey
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39
2022-01-01 Riva, Beatrice; Pessolano, Emanuela; Quaglia, Edoardo; Cordero-Sanchez, Celia; Bhela, Irene P; Topf, Ana; Serafini, Marta; Cox, Daniel; Harris, Elizabeth; Garibaldi, Matteo; Barresi, Rita; Pirali, Tracey; Genazzani, Armando
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors
2020-01-01 Serafini, M.; Cordero Sanchez, C.; Di Paola, R.; Bhela, I. P.; Aprile, S.; Purghe, B.; Fusco, R.; Cuzzocrea, S.; Genazzani, A.; Riva, B.; Pirali, T.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry | 1-gen-2021 | Aprile, Silvio; Riva, Beatrice; Bhela, Irene Preet; Cordero-Sanchez, Celia; Avino, Giulia; Genazzani, Armando; Serafini, Marta; Pirali, Tracey | |
| A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability | 1-gen-2021 | Nikolaeva-Koleva, M.; Butron, L.; Gonzalez-Rodriguez, S.; Devesa, I.; Valente, P.; Serafini, M.; Genazzani, A.; Pirali, T.; Ballester, G. F.; Fernandez-Carvajal, A.; Ferrer-Montiel, A. | |
| A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies | 1-gen-2018 | Griglio, Alessia; Torre, Enza; Serafini, Marta; Bianchi, Alice; Schmid, Roberta; CODA ZABETTA, Giulia; Massarotti, Alberto; Sorba, Giovanni; Pirali, Tracey; Fallarini, Silvia | |
| A primer of deuterium in drug design | 1-gen-2019 | Cargnin, Sarah; Serafini, Marta; Pirali, Tracey | |
| A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs | 1-gen-2022 | Bhela, Irene Preet; Ranza, Alice; Balestrero, Federica Carolina; Serafini, Marta; Aprile, Silvio; Di Martino, Rita Maria Concetta; Condorelli, Fabrizio; Pirali, Tracey | |
| An aryne-based three-component access to α-aroylamino amides | 1-gen-2017 | Serafini, Marta; Griglio, Alessia; Viarengo, Sara; Aprile, Silvio; Pirali, Tracey | |
| An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline | 1-gen-2022 | Aprile, Silvio; Colombo, Giorgia; Serafini, Marta; Di Paola, Rosanna; Pisati, Federica; Bhela, Irene Preet; Cuzzocrea, Salvatore; Grosa, Giorgio; Pirali, Tracey | |
| Applications of deuterium in medicinal chemistry | 1-gen-2019 | Pirali, Tracey; Serafini, Marta; Cargnin, Sarah; Genazzani, Armando | |
| Arynes and isocyanides: Two close-knit partners in multicomponent reactions | 1-gen-2018 | Serafini, Marta; Pirali, Tracey | |
| CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy | 1-gen-2022 | Cordero-Sanchez, Celia; Pessolano, Emanuela; Riva, Beatrice; Vismara, Mauro; Trivigno, Silvia Maria Grazia; Clemente, Nausicaa; Aprile, Silvio; Ruffinatti, Federico Alessandro; Portararo, Paola; Filigheddu, Nicoletta; Zaggia, Ivan; Bhela, Irene P; Serafini, Marta; Pirali, Tracey; Colombo, Mario P; Torti, Mauro; Sangaletti, Sabina; Bertoni, Alessandra; Genazzani, Armando | |
| Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic? | 1-gen-2020 | Serafini, M.; Pirali, T.; Tron, G. C. | |
| Discovery and development of small molecules targeting IDO1 and SOCE | 1-gen-2021 | Serafini, Marta | |
| Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity | 1-gen-2020 | Serafini, M.; Torre, E.; Aprile, S.; Del Grosso, E.; Gesu, A.; Griglio, A.; Colombo, G.; Travelli, C.; Paiella, S.; Adamo, A.; Orecchini, E.; Coletti, A.; Pallotta, M. T.; Ugel, S.; Massarotti, A.; Pirali, T.; Fallarini, S. | |
| Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction | 1-gen-2019 | Pirali, Tracey; Galli, Ubaldina; Serafini, Marta; Griglio, Alessia; Genazzani, Armando; Tron, Gian Cesare | |
| Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs | 1-gen-2017 | Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare | |
| Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis | 1-gen-2018 | Riva, Beatrice; Griglio, Alessia; Serafini, Marta; CORDERO SANCHEZ, Celia; Aprile, Silvio; Di Paola, Rosanna; Gugliandolo, Enrico; Alansary, Dalia; Biocotino, Isabella; Lim, Dmitry; Grosa, Giorgio; Galli, Ubaldina; Niemeyer, Barbara; Sorba, Giovanni; Canonico, Pier Luigi; Cuzzocrea, Salvatore; Genazzani, Armando; Pirali, Tracey | |
| SOCE: EMERGE UN NUOVO TARGET TERAPEUTICO DAL “CALCIUM TOOLKIT” DELLA CELLULA | 1-gen-2019 | Serafini, Marta; Pirali, Tracey | |
| Soft drugs for dermatological applications: recent trends | 1-gen-2019 | Aprile, Silvio; Serafini, Marta; Pirali, Tracey | |
| STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 | 1-gen-2022 | Riva, Beatrice; Pessolano, Emanuela; Quaglia, Edoardo; Cordero-Sanchez, Celia; Bhela, Irene P; Topf, Ana; Serafini, Marta; Cox, Daniel; Harris, Elizabeth; Garibaldi, Matteo; Barresi, Rita; Pirali, Tracey; Genazzani, Armando | |
| Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors | 1-gen-2020 | Serafini, M.; Cordero Sanchez, C.; Di Paola, R.; Bhela, I. P.; Aprile, S.; Purghe, B.; Fusco, R.; Cuzzocrea, S.; Genazzani, A.; Riva, B.; Pirali, T. |