Impact of therapy induced senescence in cancerous and non-cancerous cells

Cellular Senescence is an irreversible state of replicative arrest characterized by upregulation of cyclin-dependent kinase inhibitors. Over recent years, compelling evidence supports that senescent cellaccumulation negatively influences longevity by driving age-related conditions, including cancer. In thisperspective, a better characterization of the function as well as the clearance of senescent cells mightprovide an important cue to generate innovative strategies for age-related pathologie...

Development of a clinical program aimed to improve the safety of living donor kidney transplantation: the role of renal functional reserve, radioisotope glomerular filtration rate and urinary biomarkers

Background. I donatori di rene (KD) presentano un aumentato rischio di insufficienza renale cronica: ènecessaria un’accurata valutazione statica e dinamica della funzione renale pre e post-donazione, il cuirecupero è dovuto alla riserva funzionale renale (RFR) ossia la capacità di aumentare la velocità difiltrazione glomerulare in risposta a stimoli fisiologici o condizioni patologiche. E’ stato studiato il ruolo delGFR radioisotopico (mGFR), della misurazione della RFR e di biomarkers urinar...

Emergenza a risorse limitate: COVID-19 tra Italia e Africa

Pro-inflammatory cytokines and miRNA491 mediate the downregulation of AKR1C1 expression conferring oligodendrocytes sensitivity to ferroptotic cell death: potential implications for MS patients

Ferroptosis is an iron-dependent programmed cell death, regulated by specific pathways, in which iron dependentgeneration of lipid peroxidation products plays a key role. It is induced by severe oxidative stress and it has beendescribed in several neurodegenerative disorders, characterized by neuroinflammation.Multiple sclerosis (MS) is an autoimmune disease characterized by perivascular inflammation, demyelination,oligodendrocyte death, and neuronal degeneration. The mechanism of oligodendro...