Cytotoxicity in the mu M range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

N,N,N',N'-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

CALDARELLI, ANTONIO;DE BIASIO, VALERIA;GIOVENZANA, Giovanni Battista;NEGRI, Roberto
2014-01-01

Abstract

Cytotoxicity in the mu M range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11579/57240
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